Implementation of a zebrafish health program in a research facility : A 4-year retrospective study

In the past two decades, zebrafish (Danio rerio)-based research has contributed to significant scientific advances. Still, husbandry and health programs did not evolve at the same pace, as evidenced by the absence of general guidelines. Health monitoring is essential to animal welfare, to permit animal exchanges across facilities, to contribute to robust experimental results, and for data reproducibility. In this study, we report a health program implemented in a zebrafish research facility to prevent, monitor, and control pathogen, and disease dissemination. This program includes quarantine, routine health screening of sentinels, and nonroutine screenings of retired animals and sick/moribund individuals. An extensive list of clinical signs, lesions, and pathogens was monitored based on: daily observation of fish, necropsy, histology, and bacterial culture. The results indicate that the combined analysis of sentinels with the evaluation of sick/moribund animals enables a comprehensive description not only of pathogen prevalence but also of clinical and histopathologic lesions of resident animals. The establishment of a quarantine program revealed to be effective in the reduction of Pseudoloma neurophilia frequency in the main aquaria room. Finally, characterization of the colony health status based on this multiapproach program shows a low prevalence of lesions and pathogens in the facility.

Long-term health-related quality of life and walking capacity of lung recipients with and without bronchiolitis obliterans syndrome.

BACKGROUND: Outcome after lung transplantation (LTx) is affected by the onset of bronchiolitis obliterans syndrome (BOS) and lung function decline. Reduced health-related quality of life (HRQL) and physical mobility have been shown in patients developing BOS, but the impact on the capacity to walk is unknown. We aimed to compare the long-term HRQL and 6-minute walk test (6MWT) between lung recipients affected or not by BOS Grade > or =2. METHODS: Fifty-eight patients were prospectively followed for 5.6 +/- 2.9 years after LTx. Assessments included the St George's Respiratory Questionnaire (SGRQ) and the 6MWT, which were performed yearly. Moreover, clinical complications were recorded to estimate the proportion of the follow-up time lived without clinical intercurrences after transplant. Analyses were performed using adjusted linear regression and repeated-measures analysis of variance. RESULTS: BOS was a significant predictor of lower SGRQ scores (p < 0.01) and reduced time free of clinical complications (p = 0.001), but not of 6MWT distance (p = 0.12). At 7 years post-transplant, results were: 69.0 +/- 21.8% vs 86.9 +/- 5.6%, p < 0.05 (SGRQ); 58.5 +/- 21.6% vs 88.7 +/- 11.4%, p < 0.01 (proportion of time lived without clinical complications); and 82.2 +/- 10.9% vs 91.9 +/- 14.2%, p = 0.27 (percent of predicted 6MWT), respectively, for patients with BOS and without BOS. CONCLUSIONS: Despite significantly less time lived without clinical complications and progressive decline of self-reported health status, the capacity to walk of patients affected by BOS remained relatively stable over time. These findings may indicate that the development of moderate to severe BOS does not prevent lung recipients from walking independently and pursuing an autonomous life.

Health Statistics 2002

The four key principles guiding the development of the Health Strategy (2001): Quality and Fairness: A Health System for You are equity, people-centredness, quality and accountability. High quality statistical data are fundamental to the delivery of each of these. Relevant, accurate and accessible information should inform all health decisions. This includes information for the public as well as data required to enable evidence-based service delivery and evaluation, policy formulation and the measurement of health gain.This compendium of health statistics brings together data from a wide variety of sources on demography, health status and the delivery of health services. It provides a broad overview of health in Ireland as well as serving as a resource and reference for those interested in particular aspects of health and the health services. Download document here

Annual Report of the Chief Medical Officer for the year 1999

The general purpose of the Report is: To make a contribution to the debate on issues relevant to the development of public health policy. To describe aspects of the health status of the Irish people by reference to certain indicators of mortality and lifestyle. To identify particular factors which are relevant to the major disease entities affecting the Irish population. To identify a specific theme of particular contemporary relevance to health in Ireland Download the Report here

Inhabitants' and professionals' social representations of health determinants in a disadvantaged urban area in France: a qualitative analysis = représentations sociales des déterminants de santé dans une zone urbaine défavorisée en France : analyse qualitative auprès d'habitants et de professionnels

Background and objective. - Access to care in French disadvantaged urban areas remains an issue despite the implementation of local healthcare structures. To understand this contradiction, we investigated social representations held by inhabitants of such areas, as well as those of social and healthcare professionals, regarding events or behaviours that can impact low-income individuals' health. Method. - In the context of a health diagnosis, 288 inhabitants living in five disadvantaged districts of Aix-les-Bains, as well as 28 professionals working in these districts, completed an open-ended questionnaire. The two groups of respondents were asked to describe what could have an impact on health status from the inhabitants' point of view. The textual responses were analyzed using the Alceste method. Results. - We observed a number of differences in the way the inhabitants and professionals represented determinants of health in disadvantaged urban areas: the former proposed a representation mixing personal responsibility with physiological, social, familial, and professional aspects, whereas the latter associated health issues with marginalization (financial, drug, or alcohol problems) and personal responsibility. Both inhabitants and professionals mentioned control over events and lifestyle as determinants of health. Discussion. - The results are discussed regarding the consequences of these different representations on the beneficiary - healthcare-provider relationship in terms of communication and trust.

Health in Ireland, Key Trends 2007

This booklet provides an overview of selected key trends in health in Ireland in recent years. Tables and graphs are presented which summarise information on demographics, on health status and on health care in order to give a quick reference guide in major areas of health and health services. The past decade has been a time of rapid change in many aspects of life in Ireland. The evidence presented in this booklet reflects this period of change with respect to health. Download document here

All-Ireland Traveller Health Study

Summary of Findings (PDF 9.4mb) Alongside the executive summary above, this report is further broken into 3 technical reports and an appendix, which are available below. Because of their size, Technical Reports 2 and 3 are available in low-resolution format and are also broken into 4-part higher resolution versions. Technical Report 1 features the findings of the Census of Traveller Population and a Quantitative Study of Health Status and Health Utilisation Technical Report 1: Health Survey Findings (PDF 10mb) Technical Report 2 reports on Demography and Vital Statistics including mortality and life expectancy data, an initial report of the Birth Cohort Study and a report on Travellers in Institutions. The Birth Cohort Study was a 1 year follow-up of all Traveller babies born on the island of Ireland between 14th October 2008 and 13th October 2009, with data collection up to 13th October 2010. Part D of Technical Report 2 is the Birth Cohort Study Follow Up and was published in September 2011. Technical Report 2 – Parts A, B & C (PDF 12mb) Demography & Vital Statistics: Part A of Technical Report 2 (PDF 5.3mb) The Birth Cohort Study: Part B of Technical Report 2 (PDF 9.6mb) Travellers in Institutions: Part C of Technical Report 2 (PDF 4.3mb) Technical Report 2 Bibliography – Parts A, B & C (PDF 2.7mb) The Birth Cohort Study Follow Up: Part D of Technical Report 2 (including bibliography) (PDF 7.1mb) Technical Report 3 reports on Consultative Studies including qualitative studies based on focus groups and semi-structured interviews with Travellers and key discussants, and a survey of Health Service Providers Technical Report 3 : Full Report (PDF 11.8mb) Qualitative Studies: Part A of Technical Report 3 (PDF 4.2mb) Health Service Provider Study: Part B of Technical Report 3 (PDF 5.4mb) Discussion & Recommendations: Part C of Technical Report 3 (PDF 3.1mb) Technical Report 3 Bibliography (PDF 2.6mb) Preamble Health Service Providers Questionnaire for the Republic of Ireland and Northern Ireland (PDF 75kb) Questionnaire for the Republic of Ireland (PDF 326kb) Questionnaire for Northern Ireland (PDF 140kb)

All Ireland Traveller Health Study: Our Geels - The Birth Cohort Study Follow Up

The birth cohort study was a one year follow-up of all Traveller babies born on the island of Ireland between 14th October 2008 and 13th October 2009. The mother had to self-identify as an Irish Traveller. The aim of study was to assess the health status of Traveller infants and their mothers, quantify health service use, conditions needing health services and to examine why Traveller infants die. Click here to download PDF 7.72MB See all reports here

Health In Ireland: Key Trends 2011

The purpose of Health in Ireland, Key Trends 2011, as with previous editions, is to provide summary data on the main areas of health and health care over the past decade. It also aims to highlight selected trends and topics of growing concern and to include new data where it becomes available. A further objective is to assess ourselves and our progress in the broader EU context. With these goals in mind, the booklet is divided into six chapters ranging from population, life expectancy and health status through to health care delivery, staffing and costs. Click here to download PDF 2.26MB

Health In Ireland: Key Trends 2013

Health in Ireland, Key Trends 2013 provides summary statistics on health and health care over the past ten years. It also highlights selected trends and topics of growing concern and includes new data which has become available during the course of the year. An important objective is to assess ourselves and our progress in the broader EU context. The booklet is divided into six chapters ranging across population, life expectancy and health status through to health care delivery, staffing and costs. Overall, the picture which emerges is of continuing progress, but at a reduced rate, set in a context of very ignificant financial constraints. Rapid ageing of the population in conjunction with lifestyle-related health threats present major challenges now and for the future in sustaining and further improving health and health services in Ireland Click here to download PDF 3.2MB

Health Statistics 2005

The four key principles guiding the development of the Health Strategy (2001): Quality and Fairness: A Health System for You are equity, people-centredness, quality and accountability. Statistical information is fundamental to the delivery of each of these principles. This compendium of health statistics brings together data from a wide variety of sources on demography, health status and the delivery of health services. It provides a broad overview of health in Ireland as well as serving as a resource and reference for those interested in particular aspects of health and thehealth services. Read the Statistics report (PDF, 4.1mb)

A Study on Health Behaviours and Young People

Numerous reports have documented the health status of young people, concluding that the main threats to their health are predominantly the health risk behaviours and choices they make. Focussing on four of these, alcohol consumption, tobacco smoking, illicit drug use and sexual activity, this study seeks to assess their levels among a group of young people in Galway City with the aim of helping with the development of Health Education in these areas. In order to develop appropriate interventions, it is first of all necessary that accurate information on the extent of the problem, if any, be available. In 1989, studies on risk taking were carried out in the Muirhouse and Easterhouse areas of Glasgow and Edinburgh in Scotland. These areas were seen as underprivileged and had high and low rates of HIV infection respectively. In 1993, a similar study was carried out in the Westside area of Galway, an area which is also seen as under-privileged with high rates of unemployment. In 1996, a follow-up to the 1993 survey was carried out. This study also attempted to determine if there was a relationship between the behaviours reported and socio-economic class. This study is a follow-up to the previous two, with the addition that it attempts to investigate whether any relationship exists between the provision of health education in schools and subsequent health behaviour patternsThis resource was contributed by The National Documentation Centre on Drug Use.

Hiding the evidence: The State and spatial inequalities in health in Ireland

The Irish State has consistently reduced its production of publicly accessible disease / mortality maps over the last fifty years. State health statistics, and the small number of disease / mortality maps that have been produced in official publications, show a declining level of detail and are routinely out of date. Following a review of the production of disease / mortality maps in Ireland by the State and allied health agencies, two reasons are suggested for this decline. The first explanation relates to spatial inequalities in healthcare provision and to the absence of a health funding formulae in Ireland. The second explanation focuses on the potential politicisation of spatial inequalities in health status. Researchers in these fields are urged to disseminate information widely on spatial inequalities in healthcare provision, healthcare access and health status, both within and outside of the academic literature. Researchers in these fields are also urged to adopt an advocacy role on these issues, or to develop strategic alliances with such advocates.����

Indications of public health in the English regions - 7: mental health

This report is the eigth in the series, "Indications of Public Health in the English Regions" commissioned by the Chief Medical Officer and has been produced jointly by the Association of Public Health Observatories (APHO) and the North East PHO. This report presents a wide range of data on the factors which can give rise to poor mental health, the mental health status of populations, provision of interventions of care for mental illness, service user experience and traditional outcomes such as suicide. In 2006, the United Kingdom rated third highest across 25 EU member states for the number of drinks consumed in one sitting. This Regional Indications report is produced alongside the new national strategy Safe. Sensible. Social: The next steps in the National Alcohol Strategy.