Movement control of manipulative tasks in patients with Gilles de la Tourette syndrome

When a hand-held object is moved, grip and load force are accurately coordinated for establishing grasp stability. In the present work, the question was raised whether patients with Gilles de la Tourette syndrome (TS), who show tic-like movements, are impaired in grip-load force control when executing a manipulative task. To this end, we assessed force regulation during action patterns that required rhythmical unimanual or bimanual (iso-directional/anti-directional) movements. Results showed that the profile of grip-load force ratio was characterized by maxima and minima that were realized at upward and downward hand positions, respectively. TS patients showed increased force ratios during unimanual and bimanual movements, compared with control subjects, indicative of an inaccurate specification of the precision grip. Functional imaging data complemented the behavioural results and revealed that secondary motor areas showed no (or greatly reduced) activation in TS patients when executing the movement tasks as compared with baseline conditions. This indicates that the metabolic level in the secondary motor areas was equal during rest and task performance. At the neuronal level, this observation suggests that these cortical areas were continuously involved in movement preparation. Based on these data, we conclude that the ongoing activation of secondary motor areas may be explained by the TS patients' involuntary urges to move. Accordingly, interference will prevent an accurate planning of voluntary behaviour. Together, these findings reveal modulations in movement organization in patients with TS and exemplify degrading consequences for manual function.

Altered structure of cortical sulci in gilles de la Tourette syndrome: Further support for abnormal brain development.

Gilles de la Tourette syndrome is a neurodevelopmental disorder characterized by the presence of motor and vocal tics. We hypothesized that patients with this syndrome would present an aberrant pattern of cortical formation, which could potentially reflect global alterations of brain development. Using 3 Tesla structural neuroimaging, we compared sulcal depth, opening, and length and thickness of sulcal gray matter in 52 adult patients and 52 matched controls. Cortical sulci were automatically reconstructed and identified over the whole brain, using BrainVisa software. We focused on frontal, parietal, and temporal cortical regions, in which abnormal structure and functional activity were identified in previous neuroimaging studies. Partial correlation analysis with age, sex, and treatment as covariables of noninterest was performed amongst relevant clinical and neuroimaging variables in patients. Patients with Gilles de la Tourette syndrome showed lower depth and reduced thickness of gray matter in the pre- and post-central as well as superior, inferior, and internal frontal sulci. In patients with associated obsessive-compulsive disorder, additional structural changes were found in temporal, insular, and olfactory sulci. Crucially, severity of tics and of obsessive-compulsive disorder measured by Yale Global Tic severity scale and Yale-Brown Obsessive-Compulsive scale, respectively, correlated with structural sulcal changes in sensorimotor, temporal, dorsolateral prefrontal, and middle cingulate cortical areas. Patients with Gilles de la Tourette syndrome displayed an abnormal structural pattern of cortical sulci, which correlated with severity of clinical symptoms. Our results provide further evidence of abnormal brain development in GTS. © 2015 International Parkinson and Movement Disorder Society.

El concepto deleuziano de “functor"

El artículo repasa la concepción deleuziana de la filosofía de la ciencia con el objeto de intentar explicitar el rol determinante que su proyecto ontológico (i.e., la concepción del ser en términos de “repetición de la diferencia") pareciera desempeñar en su doble caracterización del producto de la actividad científica: por una parte, en lo que respecta a la cognición científica y a partir de la crítica de la representación, su revisión de la noción de “función"; por otra, en lo que se refiere al pensamiento científico y en virtud de su crítica de la identidad, la elaboración de la noción de “functor".

Liberación y esquizofrenia en "Tengo" de Nicolás Guillén

Escrito en el apogeo de la Revolución Cubana, “Tengo," que comparte el nombre del libro donde aparece, es una celebración eufórica del triunfo del hombre común y corriente. También documenta el punto de cambio de la doxa, al mostrar cómo “Juan sin nada" se convirtió en “Juan con todo". Esta investigación utiliza la teoría bourdieusiana para documentar cómo los cambios sociales deben aparecer en el nivel de habitus antes de manifestarse en el nivel físico. Este fallo tiene consecuencias muy importante para el poeta como “maestro de memes".

El deseo en Butler y Deleuze : Algunas reflexiones

Fil: Casale, Rolando Héctor. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

La cuestión del cuerpo en las filosofías de A. Kojève, G. Bataille, G. Deleuze y G. Agamben

Fil: Prósperi, Germán Osvaldo. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.