994 resultados para G8630 1887 .B6
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Recurso electrónico. Valencia: BVNP, 2014
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Recurso electrónico. Valencia: BVNP, 2014
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Recurso electrónico. Valencia: BVNP, 2014
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Recurso electrónico. Valencia: BVNP, 2014
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Recurso electrónico. Valencia: BVNP, 2014
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Recurso electrónico. Valencia: BVNP, 2014
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Recurso electrónico. Valencia: BVNP, 2014
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Recurso electrónico. Valencia: BVNP, 2014
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Recurso electrónico. Valencia: BVNP, 2014
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Recurso electrónico. Valencia: BVNP, 2014
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The three-dimensional structure of glutamate-1-semialdehyde aminomutase (EC 5.4.3.8), an α2-dimeric enzyme from Synechococcus, has been determined by x-ray crystallography using heavy atom derivative phasing. The structure, refined at 2.4-Å resolution to an R-factor of 18.7% and good stereochemistry, explains many of the enzyme’s unusual specificity and functional properties. The overall fold is that of aspartate aminotransferase and related B6 enzymes, but it also has specific features. The structure of the complex with gabaculine, a substrate analogue, shows unexpectedly that the substrate binding site involves residues from the N-terminal domain of the molecule, notably Arg-32. Glu-406 is suitably positioned to repel α-carboxylic acids, thereby suggesting a basis for the enzyme’s reaction specificity. The subunits show asymmetry in cofactor binding and in the mobilities of the residues 153–181. In the unliganded enzyme, one subunit has the cofactor bound as an aldimine of pyridoxal phosphate with Lys-273 and, in this subunit, residues 153–181 are disordered. In the other subunit in which the cofactor is not covalently bound, residues 153–181 are well defined. Consistent with the crystallographically demonstrated asymmetry, a form of the enzyme in which both subunits have pyridoxal phosphate bound to Lys-273 through a Schiff base showed biphasic reduction by borohydride in solution. Analysis of absorption spectra during reduction provided evidence of communication between the subunits. The crystal structure of the reduced form of the enzyme shows that, despite identical cofactor binding in each monomer, the structural asymmetry at residues 153–181 remains.
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The genre of historical women's biography has a moderately short history, and has evolved into the twenty-first century as women's studies. Simultaneously, biography has become a multifaceted genre that keeps a close relationship between biography, history, women's studies, and cultural studies. The biography of Josephine Evans embraces the genre as a vehicle to enlighten broader historical issues, as the life of an ordinary woman and her position in an historic Colorado family is revealed. Her story contributes to the history of women's roles and rights in the late nineteenth and twentieth century as her life story is representative of the time period. This biography of Josephine Evans is an illustration of a biography written from personal letters, diaries, and recollections.
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Una sospecha de usurpación y plagio se cierne sobre el libro de José Arévalo Baca Aves de España (1887). Una carta en 1893 de Mariano de la Paz Graells a Víctor López Seoane es un documento probatorio de que Arévalo Baca robó a la viuda de Cisternas un manuscrito y lo utilizó apropiándoselo para la redacción del considerado primer libro español de ornitología ibérica. Además de mostrar aquí esta prueba, se presentan otros indicios y evidencias que hemos podido reunir para fundamentar la sospecha de que Arévalo Baca cometió un fraude científico.
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This layer is a georeferenced raster image of the historic paper map entitled: Central Africa : on a scale of 1:10,000,000, By Dr. F. Boas. It was published by Hart & Von Arx in 1887. Scale 1:10,000,000 The image inside the map neatline is georeferenced to the surface of the earth and fit to the Africa Sinusoidal projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, shoreline features, and more. Relief shown by shading. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.
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This layer is a georeferenced raster image of the historic paper map entitled: Map of the State of Rhode Island and Providence Plantations. It was compiled and published by J.C. Thompson in 1887. Scale 1:95,000. Source map and image missing bottom panels, including part of title; description based partly on published bibliography. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Rhode Island State Plane Coordinate System (Feet) (FIPS 3800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), selected private residences, town and county boundaries and more. Relief shown by hachures. Includes population statistics from the census of 1875 and 1885. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and map purposes.
