Iowa African-American Journal, Spring 2004, Vol. 9, no. 1

Newsletter for the Iowa Commission on the Status of African-Americans

Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice

The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.

Monitoring multiple angiogenesis-related molecules in the blood of cancer patients shows a correlation between VEGF-A and MMP-9 levels before treatment and divergent changes after surgical vs. conservative therapy.

Anti-angiogenic therapies are currently in cancer clinical trials, but to date there are no established tests for evaluating the angiogenic status of a patient. We measured 11 circulating angiogenesis-associated molecules in cancer patients before and after local treatment. The purpose of our study was to screen for possible relationships among the different molecules and between individual molecules and tumor burden. We measured VEGF-A, PlGF, SCF, MMP-9, EDB+ -fibronectin, sVEGFR-2, sVEGFR-1, salphaVbeta3, sTie-2, IL-8 and CRP in the blood of 22 healthy volunteers, 17 early breast, 17 early colorectal, and 8 advanced sarcoma/melanoma cancer patients. Breast cancer patients had elevated levels of VEGF-A and sTie-2, colorectal cancer patients of VEGF-A, MMP-9, sTie-2, IL-8 and CRP, and melanoma/sarcoma patients of sVEGFR-1. salphaVbeta3 was decreased in colorectal cancer patients. A correlation between VEGF-A and MMP-9 was found. After tumor removal, MMP-9 and salphaVbeta3 significantly decreased in breast and CRP in colorectal cancer, whereas sVEGFR-1 increased in colorectal cancer patients. In sarcoma/melanoma patients treated regionally with TNF and chemotherapy we observed a rise in VEGF-A, SCF, VEGFR-2, MMP-9, Tie-2 and CRP, a correlation between CRP and IL-8, and a decreased in sVEGFR-1 levels. In conclusion, among all factors measured, only VEGF-A and MMP-9 consistently correlated to each other, elevated CRP levels were associated with tumor burden, whereas sVEGF-R1 increased after tumor removal in colorectal cancer. Treatment with chemotherapy and TNF induced changes consistent with an angiogenic switch. These results warrant a prospective study to compare the effect of surgical tumor removal vs. chemotherapy on some of these markers and to evaluate their prognostic/predictive value.

Lottery Action, May 2-12, 2005, Vol. 12, no. 9

Iowa Lottery Authority Retailer Newsletter

ABD e-News September 9, 2005

Weekly Newsletter

Acreage Living, December 1999, Vol 5, no.9

Acreage Living newsletter for those persons living on or interested in acreage living.

Footnotes, September/October 2005, Vol. 29, no. 9/10

Monthly newsletter of the State Library

Acreage Living, September 2000, Vol.6, no.9

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, September 2001, Vol.7, no.9

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, September 2001, Vol.7, no.9

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.

Acreage Living, October 2002, Vol.8, no.9

Monthly newsletter for people in Iowa that live on Acreages, produced by Iowa State University Copperative Extension.