Code pénal général de l'empire d'Autriche : avec des appendices contenant les règlements généraux les plus récents / traduit sur la dernière édition officielle par M. Victor Foucher,...

Collection : Collection des lois civiles et criminelles des Etats modernes ; 1ère livraison

Granulocyte colony-stimulating factor in the treatment of high-risk febrile neutropenia: a multicenter randomized trial.

BACKGROUND Granulocyte colony-stimulating factors (G-CSFs) have been shown to help prevent febrile neutropenia in certain subgroups of cancer patients undergoing chemotherapy, but their role in treating febrile neutropenia is controversial. The purpose of our study was to evaluate-in a prospective multicenter randomized clinical trial-the efficacy of adding G-CSF to broad-spectrum antibiotic treatment of patients with solid tumors and high-risk febrile neutropenia. METHODS A total of 210 patients with solid tumors treated with conventional-dose chemotherapy who presented with fever and grade IV neutropenia were considered to be eligible for the trial. They met at least one of the following high-risk criteria: profound neutropenia (absolute neutrophil count <100/mm(3)), short latency from previous chemotherapy cycle (<10 days), sepsis or clinically documented infection at presentation, severe comorbidity, performance status of 3-4 (Eastern Cooperative Oncology Group scale), or prior inpatient status. Eligible patients were randomly assigned to receive the antibiotics ceftazidime and amikacin, with or without G-CSF (5 microg/kg per day). The primary study end point was the duration of hospitalization. All P values were two-sided. RESULTS Patients randomly assigned to receive G-CSF had a significantly shorter duration of grade IV neutropenia (median, 2 days versus 3 days; P = 0.0004), antibiotic therapy (median, 5 days versus 6 days; P = 0.013), and hospital stay (median, 5 days versus 7 days; P = 0.015) than patients in the control arm. The incidence of serious medical complications not present at the initial clinical evaluation was 10% in the G-CSF group and 17% in the control group (P = 0.12), including five deaths in each study arm. The median cost of hospital stay and the median overall cost per patient admission were reduced by 17% (P = 0.01) and by 11% (P = 0.07), respectively, in the G-CSF arm compared with the control arm. CONCLUSIONS Adding G-CSF to antibiotic therapy shortens the duration of neutropenia, reduces the duration of antibiotic therapy and hospitalization, and decreases hospital costs in patients with high-risk febrile neutropenia.

Differential outcome of concurrent radiotherapy plus epidermal growth factor receptor inhibitors versus radiotherapy plus cisplatin in patients with human papillomavirus-related head and neck cancer.

BACKGROUND Human papillomavirus (HPV)-related head and neck cancer has been associated with an improved prognosis in patients treated with radiotherapy (RT) +/- chemotherapy (CT); however, RT combined with epidermal growth factor receptor (EGFR) inhibitors has not been fully studied in this group of patients. METHODS Immunohistochemical expression of p16 and PCR of HPV16 DNA were retrospectively analyzed in tumor blocks from 108 stage III/IV head and neck cancer patients treated with RT+CT (56) or RT+EGFR inhibitors (52). Disease-free survival (DFS) and overall survival (OS) were analyzed by the Kaplan-Meier method. RESULTS DNA of HPV16 was found in 12 of 108 tumors (11%) and p16 positivity in 18 tumors (17%), with similar rates in both arms of treatment. After a median follow-up time of 35 months (range 6-135), p16-positive patients treated with RT+EGFR inhibitors showed improved survival compared with those treated with RT+CT (2-year OS 88% vs. 60%, HR 0.18; 95% CI 0.04 to 0.88; p = 0.01; and 2-year DFS 75% vs. 47%, HR 0.17; 95% CI 0.03 to 0.8; p = 0.01). However, no differences were observed in p16-negative patients (2-year OS 56% vs. 53%, HR 0.97; 95% CI 0.55 to 1.7; p = 0.9; and 2-year DFS 43% vs. 45%, HR 0.99; 95% CI 0.57 to 1.7; p = 0.9). CONCLUSIONS This is the first study to show that p16-positive patients may benefit more from RT+EGFR inhibitors than conventional RT+CT. These results are hypothesis-generating and should be confirmed in prospective trials.

Le théâtre moral de la vie humaine , représentée en plus de cent tableaux divers tirez du poëte Horace par le sieur Otho Venius, et expliquez en autant de discours moraux par le sieur de Gomberville. Avec la table du philosophe Cebes

Comprend : [Epigramma] ; La Table

Oeuvres de La Rochefoucauld. [Mémoires]. Tome 1 / nouv. éd. revue sur les plus anciennes impressions et augm. de morceaux inédits, de variantes, de notices, de notes, de tables particulières pour les "Maximes" et pour les "Mémoires", d'un lexique des mots et locutions remarquables, d'un portr., de fac-sim., etc. par MM. D. L. Gilbert et J. Gourdault

Collection : Les grands écrivains de la France

Oeuvres de La Rochefoucauld. [Mémoires]. Tome 3 / Partie 1 / nouv. éd. revue sur les plus anciennes impressions et augm. de morceaux inédits, de variantes, de notices, de notes, de tables particulières pour les "Maximes" et pour les "Mémoires", d'un lexique des mots et locutions remarquables, d'un portr., de fac-sim., etc. par MM. D. L. Gilbert et J. Gourdault

Collection : Les grands écrivains de la France

Oeuvres de La Rochefoucauld. [Mémoires]. Tome 3 / Partie 2 / nouv. éd. revue sur les plus anciennes impressions et augm. de morceaux inédits, de variantes, de notices, de notes, de tables particulières pour les "Maximes" et pour les "Mémoires", d'un lexique des mots et locutions remarquables, d'un portr., de fac-sim., etc. par MM. D. L. Gilbert et J. Gourdault

Collection : Les grands écrivains de la France

Oeuvres de La Rochefoucauld. [Mémoires]. Tome 2 / nouv. éd. revue sur les plus anciennes impressions et augm. de morceaux inédits, de variantes, de notices, de notes, de tables particulières pour les "Maximes" et pour les "Mémoires", d'un lexique des mots et locutions remarquables, d'un portr., de fac-sim., etc. par MM. D. L. Gilbert et J. Gourdault

Collection : Les grands écrivains de la France