Encyclopédie d'histoire naturelle; ou, traité complet de cette science d'après les travaux des naturalistes les plus éminents de tous les pays et de toutes les époques: Buffon, Daubenton, Lacépède, G. Cuvier, F. Cuvier, Geoffroy Saint-Hilaire, Latreille, De Jussieu, Brongniart, etc.

Coléoptères No.1

Bulletin Zoologique : Contenant l'Analyse Raisonnee des Ouvrages les plus Remarquables.

1835

Die Rezeption von Kundenzeitschriften gesetzlicher Krankenkassen : Eine qualitative Untersuchung am Beispiel des „Gesundheitstelegramms“ der IKK gesund plus

Kundenmagazine sind ein wichtiges Instrument des Marketing und der Öffentlichkeitsarbeit. Dies haben auch die gesetzlichen Krankenkassen erkannt. Im Rahmen des Wettbewerbs nutzen sie ihre Kundenzeitschriften zur Mitgliedererhaltung. Wie aber werden diese Zeitschriften von ihrer Leserschaft rezipiert und welche Handlungsmotive liegen dem zugrunde? Im Rahmen einer qualitativen Untersuchung wurde dies anhand von Befragungen der Rezipienten des "Gesundheitstelegramms" der IKK gesund plus analysiert.

pressure resistance of hollow glass fibers at internal pressure load

Otto-von-Guericke-Universität Magdeburg, Fakultät für Maschinenbau, Univ., Dissertation, 2015

The Walters meteorite / Sharat Kumar Roy -- , Jewell J. Glass -- [and] Edward P. Henderson --.

v.10:no.37(1960)

Encyclopédie d'histoire naturelle; ou, traité complet de cette science d'après les travaux des naturalistes les plus éminents de tous les pays et de toutes les époques: Buffon, Daubenton, Lacépède, G. Cuvier, F. Cuvier, Geoffroy Saint-Hilaire, Latreille, De Jussieu, Brongniart, etc.

Coléoptères No.2

Flore des serres et des jardins de l'Europe :ou descriptions et figures des plantes les plus rares et les plus méritantes, nouvellement introduites sur le continent ou en Angleterre ...

v.14 (1859-1861)

Annales d'horticulture et de botanique, ou Flore des jardins du royaume des Pays-Bas, et histoire des plantes cultivées les plus intéressantes des possessions néerlandaises aux Indes orientales, en Amérique et du Japon.

4

Aplicatiu de gestió de material multimèdia produït amb Dalet Plus

A principis de 2002, a la facultat de Ciències de la Comunicació de la Universitat Autònoma de Barcelona es va implantar un sistema de digitalització d'àudio, per tal de modernitzar els laboratoris de ràdio i adaptar-los a la realitat actual dels massmedia. Aquest sistema, anomenat Dalet Plus, permet produir, editar i gestionar material multimèdia relacionat amb les assignatures de ràdio impartides a la facultat. Fins ara, no existia cap aplicació que gestionés el material de cursos anteriors produït amb el sistema Dalet. L'objectiu d'aquest projecte, és desenvolupar una aplicació en entorn web, accessible a tothom, per a que alumnes, professors i tècnics puguin consultar, reproduir i recuperar, el material produït amb el sistema Dalet Plus de cursos anteriors.

Use of DNA profiles for investigation using a simulated national DNA database: Part I. Partial SGM Plus profiles.

In traditional criminal investigation, uncertainties are often dealt with using a combination of common sense, practical considerations and experience, but rarely with tailored statistical models. For example, in some countries, in order to search for a given profile in the national DNA database, it must have allelic information for six or more of the ten SGM Plus loci for a simple trace. If the profile does not have this amount of information then it cannot be searched in the national DNA database (NDNAD). This requirement (of a result at six or more loci) is not based on a statistical approach, but rather on the feeling that six or more would be sufficient. A statistical approach, however, could be more rigorous and objective and would take into consideration factors such as the probability of adventitious matches relative to the actual database size and/or investigator's requirements in a sensible way. Therefore, this research was undertaken to establish scientific foundations pertaining to the use of partial SGM Plus loci profiles (or similar) for investigation.

MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial.

BACKGROUND: Immunotherapy offers a promising novel approach for the treatment of cancer and both adoptive T-cell transfer and immune modulation lead to regression of advanced melanoma. However, the potential synergy between these two strategies remains unclear. METHODS: We investigated in 12 patients with advanced stage IV melanoma the effect of multiple MART-1 analog peptide vaccinations with (n = 6) or without (n = 6) IMP321 (LAG-3Ig fusion protein) as an adjuvant in combination with lymphodepleting chemotherapy and adoptive transfer of autologous PBMCs at day (D) 0 (Trial registration No: NCT00324623). All patients were selected on the basis of ex vivo detectable MART-1-specific CD8 T-cell responses and immunized at D0, 8, 15, 22, 28, 52, and 74 post-reinfusion. RESULTS: After immunization, a significant expansion of MART-1-specific CD8 T cells was measured in 83% (n = 5/6) and 17% (n = 1/6) of patients from the IMP321 and control groups, respectively (P < 0.02). Compared to the control group, the mean fold increase of MART-1-specific CD8 T cells in the IMP321 group was respectively >2-, >4- and >6-fold higher at D15, D30 and D60 (P < 0.02). Long-lasting MART-1-specific CD8 T-cell responses were significantly associated with IMP321 (P < 0.02). At the peak of the response, MART-1-specific CD8 T cells contained higher proportions of effector (CCR7⁻ CD45RA⁺/⁻) cells in the IMP321 group (P < 0.02) and showed no sign of exhaustion (i.e. were mostly PD1⁻CD160⁻TIM3⁻LAG3⁻2B4⁺/⁻). Moreover, IMP321 was associated with a significantly reduced expansion of regulatory T cells (P < 0.04); consistently, we observed a negative correlation between the relative expansion of MART-1-specific CD8 T cells and of regulatory T cells. Finally, although there were no confirmed responses as per RECIST criteria, a transient, 30-day partial response was observed in a patient from the IMP321 group. CONCLUSIONS: Vaccination with IMP321 as an adjuvant in combination with lymphodepleting chemotherapy and adoptive transfer of autologous PBMCs induced more robust and durable cellular antitumor immune responses, supporting further development of IMP321 as an adjuvant for future immunotherapeutic strategies.