SCHOOL PROTECTION SYSTEM: PROTECTING WHO, FROM WHOM?

The main objective of this article is to analyze the policy implanted in the schools in the State of São Paulo, Brazil, with a view to the prevention and intervention in the violence that occurs in the schools. The importance of such discussion is related to the analysis of the principles that are present and of the possible effectiveness of such a program in the school violence. This research is qualitative and the research methodology used was documentary analysis. The documents analyzed were those related to the policy of preventing violence in schools in the state of São Paulo/Brazil, called Protection System School. (C) 2012 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of The Association of Science, Education and Technology

Cutting characteristics of dental diamond burs made with CVD technology

The aim of this study was to determine the cutting ability of chemical vapor deposition (CVD) diamond burs coupled to an ultrasonic dental unit handpiece for minimally invasive cavity preparation. One standard cavity was prepared on the mesial and distal surfaces of 40 extracted human third molars either with cylindrical or with spherical CVD burs. The cutting ability was compared regarding type of substrate (enamel and dentin) and direction of handpiece motion. The morphological characteristics, width and depth of the cavities were analyzed and measured using scanning electron micrographs. Statistical analysis using the Kruskal-Wallis test (p < 0.05) revealed that the width and depth of the cavities were significantly greater when they were prepared on dentin. Wider cavities were prepared when the cylindrical CVD bur was used, and deeper cavities resulted from preparation with the spherical CVD bur. The direction of handpiece motion did not influence the size of the cavities, and the CVD burs produced precise and conservative cutting.

Molecular modeling databases: A new way in the search of protein targets for drug development

DBMODELING is a relational database of annotated comparative protein structure models and their metabolic, pathway characterization. It is focused on enzymes identified in the genomes of Mycobacterium tuberculosis and Xylella fastidiosa. The main goal of the present database is to provide structural models to be used in docking simulations and drug design. However, since the accuracy of structural models is highly dependent on sequence identity between template and target, it is necessary to make clear to the user that only models which show high structural quality should be used in such efforts. Molecular modeling of these genomes generated a database, in which all structural models were built using alignments presenting more than 30% of sequence identity, generating models with medium and high accuracy. All models in the database are publicly accessible at http://www.biocristalografia.df.ibilce.unesp.br/tools. DBMODELING user interface provides users friendly menus, so that all information can be printed in one stop from any web browser. Furthermore, DBMODELING also provides a docking interface, which allows the user to carry out geometric docking simulation, against the molecular models available in the database. There are three other important homology model databases: MODBASE, SWISSMODEL, and GTOP. The main applications of these databases are described in the present article. © 2007 Bentham Science Publishers Ltd.

Chorismate synthase: An attractive target for drug development against orphan diseases

The increase in incidence of infectious diseases worldwide, particularly in developing countries, is worrying. Each year, 14 million people are killed by infectious diseases, mainly HIV/AIDS, respiratory infections, malaria and tuberculosis. Despite the great burden in the poor countries, drug discovery to treat tropical diseases has come to a standstill. There is no interest by the pharmaceutical industry in drug development against the major diseases of the poor countries, since the financial return cannot be guaranteed. This has created an urgent need for new therapeutics to neglected diseases. A possible approach has been the exploitation of the inhibition of unique targets, vital to the pathogen such as the shikimate pathway enzymes, which are present in bacteria, fungi and apicomplexan parasites but are absent in mammals. The chorismate synthase (CS) catalyses the seventh step in this pathway, the conversion of 5-enolpyruvylshikimate-3-phosphate to chorismate. The strict requirement for a reduced flavin mononucleotide and the anti 1,4 elimination are both unusual aspects which make CS reaction unique among flavin-dependent enzymes, representing an important target for the chemotherapeutic agents development. In this review we present the main biochemical features of CS from bacterial and fungal sources and their difference from the apicomplexan CS. The CS mechanisms proposed are discussed and compared with structural data. The CS structures of some organisms are compared and their distinct features analyzed. Some known CS inhibitors are presented and the main characteristics are discussed. The structural and kinetics data reviewed here can be useful for the design of inhibitors. © 2007 Bentham Science Publishers Ltd.

Micro-CT assessment of two different endodontic preparation systems

The aim of this study was to compare two endodontic preparation systems using micro-CT analysis. Twenty-four one-rooted mandibular premolars were selected and randomly assigned to two groups. The samples (n = 12) of Group 1 were prepared using the ProTaper Universal rotary system, while Group 2 (n = 12) was prepared using the EndoEZE AET system complemented by manual apical preparation with K-type hand files up to #30. A 2.5% sodium hypochlorite solution was used in both groups for irrigating. Both groups were scanned by highresolution microcomputed tomography before and after preparation (SkyScan 1172, SkyScan, Kontich, Belgium). The root canal volume and surface area was measured before and after preparation, and the differences were calculated and analyzed for statistically significant differences using ANOVA complemented by the Tukey test (p < 0.05). The results showed no statistically significant differences between the mean volumes of dentin removal by the two systems. However, the EndoEZE AET system presented a significantly greater mean surface area compared to the ProTaper system (p < 0.05). The EndoEZE AET system enabled preparation of a greater root canal surface area when compared to the ProTaper Universal system. There seemed to be no difference in dentin volume loss between the two systems used.

A escrita icônica: design gráfico, poesia visual e seus entrelaçamentos

Pós-graduação em Artes - IA

Recomendações ergonômicas para o projeto de cadeira de rodas: considerando os aspectos fisiológicos e cognitivos dos idosos

Pós-graduação em Design - FAAC

Professores das séries iniciais do ensino fundamental e as feiras de ciências

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O uso de objetos educacionais no ensino de Física e suas relações com o processo de inclusão

Pós-graduação em Educação - FCT

A Teoria das inteligências múltiplas no ensino e aprendizagem de língua inglesa na escola pública

Pós-graduação em Estudos Linguísticos - IBILCE

Gestão energética e ambiental de edificações: avaliação de metodologias para certificação

Pós-graduação em Engenharia Mecânica - FEG

Sentidos sobre o ensino de biologia e sobre a trajetória formativa: as vozes dos licenciandos sob a égide da perspectiva crítica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A articulação das culturas humanísticas e científica por meio do estudo histórico-sociocultural dos trabalhos de James Prescott Joule: contribuições para a formação de professores universitários em uma perspectiva transformadora

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ciberespaço, técnica e hermenêutica: diálogos da ciência da informação

Pós-graduação em Ciência da Informação - FFC

Dois jogos de linguagem: a informática e a matemática na aprendizagem de função quadrática

Esta pesquisa foi realizada com o objetivo de identificar e analisar as relações entre as linguagens da Matemática e da Informática no contexto da sala de aula, a partir da inserção das tecnologias informáticas na aprendizagem da Função Quadrática. Nesse sentido, os conceitos que envolvem a forma algébrica e forma gráfica desta função, foram observados pelos alunos ao explorar aspectos dinâmicos na interface do Geogebra. A fundamentação teórica da pesquisa, foi subsidiada pelas ideias de Pierre Lévy sobre as tecnologias da inteligência na disseminação da informação e do conhecimento, bem como pelas contribuições filosóficas de Ludwig Wittgenstein acerca do jogo de linguagem. A metodologia da pesquisa possui caráter qualitativo definido a partir de critérios específicos acerca do objeto de estudo e dos sujeitos investigados. As informações foram obtidas por meio de questões específicas aplicadas em dois momentos, a saber: antes e após a realização de um minicurso sobre o GeoGebra. As análises das questões revelaram que os aspectos visuais e os movimentos no uso do computador, estabelecem relações entre as formas algébricas e gráficas da função quadrática. Assim, eles puderam perceber que os coeficientes numéricos modificam a parábola e isso dá sentido aos conceitos estudados. O uso do GeoGebra possibilita outras formas de aprendizagem evidenciadas entre o Jogo de Linguagem da Matemática e o Jogo de Linguagem da Informática no âmbito da Educação Matemática.