Coiled bodies contain U7 small nuclear RNA and associate with specific DNA sequences in interphase human cells.

Coiled bodies (CBs) are nuclear organelles whose structures appear to be highly conserved in evolution. In rapidly cycling cells, they are typically located in the nucleoplasm but are often found in contact with the nucleolus. The CBs in human cells contain a unique protein, called p80-coilin. Studies on amphibian oocyte nuclei have revealed a protein within the "sphere" organelle that shares significant structural similarity to p80-coilin. Spheres and CBs are also highly enriched in small nuclear ribonucleoproteins and other RNA-processing components. We present evidence that, like spheres, CBs contain U7 small nuclear RNA (snRNA) and associate with specific chromosomal loci. Using biotinylated 2'-O-methyl oligonucleotides complementary to the 5' end of U7 snRNA and fluorescence in situ hybridization, we show that U7 is distributed throughout the nucleoplasm, excluding nucleoli, and is concentrated in CBs. Interestingly, we found that CBs often associate with subsets of the histone, U1, and U2 snRNA gene loci in interphase HeLa-ATCC and HEp-2 monolayer cells. However, in a strain of suspension-grown HeLa cells, called HeLa-JS1000, we found a much lower rate of association between CBs and snRNA genes. Possible roles for CBs in the metabolism of these various histone and snRNAs are discussed.

Neural-network-based classification of cognitively normal, demented, Alzheimer disease and vascular dementia from single photon emission with computed tomography image data from brain.

Single photon emission with computed tomography (SPECT) hexamethylphenylethyleneamineoxime technetium-99 images were analyzed by an optimal interpolative neural network (OINN) algorithm to determine whether the network could discriminate among clinically diagnosed groups of elderly normal, Alzheimer disease (AD), and vascular dementia (VD) subjects. After initial image preprocessing and registration, image features were obtained that were representative of the mean regional tissue uptake. These features were extracted from a given image by averaging the intensities over various regions defined by suitable masks. After training, the network classified independent trials of patients whose clinical diagnoses conformed to published criteria for probable AD or probable/possible VD. For the SPECT data used in the current tests, the OINN agreement was 80 and 86% for probable AD and probable/possible VD, respectively. These results suggest that artificial neural network methods offer potential in diagnoses from brain images and possibly in other areas of scientific research where complex patterns of data may have scientifically meaningful groupings that are not easily identifiable by the researcher.

Leadless decorative tiles, faience, and mosaic, comprising notes and excerpts on the history, materials, manufacture & use of ornamental flooring tiles, ceramic mosaic, and decorative tiles and faience, with complete series of recipes for tile-bodies, and for leadless glazes and art-tile enamels,

Mode of access: Internet.

Parliamentary law and rules of procedure : a manual of practical information concerning deliberative bodies; motions and their purpose and relation; voting; elections; committees; officers and debate; together with model forms and reference charts; in accordance with Robert's rules of order, revised 1915 /

Mode of access: Internet.

A dictionary of chemistry, exhibiting the present state of the theory and practice of that science, its application to natural philosophy, the processes of manufactures, metallurgy, and numerous other arts dependant on the properties and habitudes of bodies, in the mineral, vegetable, and animal kingdoms. With a considerable number of tables, expressing the elective attractions, specific gravities, comparative heats, component parts, combinations, and other affections of the objects of chemical research. Illustrated with engravings.

Paged continuously.

An elementary treatise on the dynamics of a system of rigid bodies, with numerous examples.

Mode of access: Internet.

The elementary part of A treatise on the dynamics of a system of rigid bodies. Being part I. of a treatise on the whole subject. With numerous examples.

"Reprint of the 7th ed. without corrections"

An experimental inquiry into the cause of the changes of colours in opake and coloured bodies. With an historical preface relative to the parts of philosophy therein examined, and to the several arts and manufactures dependent upon them.

The last section, p. [95]-138, is entitled: "A letter to the right honorable the Earl of Morton, president of the Royal Society, containing experiments and observations on the agreement between the specific gravities of the several metals, and their colours when united to glass, as well as those of their other preparations. With additions. By Edward Delaval, F. R. S. Read at the Royal Society, Jan. 24, 1765."

The wisdom of God manifested in the works of the creation : in two parts. Viz. The heavenly bodies, elements, meteors, fossils, vegetables, animals (beasts, birds, fishes, and insects), more particularly in the body of the earth, its figure, motion, and consistency, and in the admirable structure of the bodies of man and other animals, as also in their generation, &c. : with answers to some objections /

First published: 1691.

A general chronological history of the air, weather, seasons, meteors, &c. in sundry places and different times : more particularly for the space of 250 years : together with some of their most remarkable effects on animal (especially human) bodies and vegetables.

Includes index.

Physiology for the young. Our bodies; or, How we live. An elementary text-book of physiology and hygiene for use in the common schools, with special reference to the effects of stimulants and narcotics on the human system,

Published also under title: Our bodies and how we live.

Temperature gradient and thermal stresses in bodies with uniformly distributed volume heat sources.

Mode of access: Internet.

A treatise on the law of libel and the liberty of the press; showing the origin, use, and abuse of the law of libel: with copious notes and references to authorities in Great Britain and the United States: as applicable to individuals and to political and ecclesiastical bodies and principles.

Microfilm. Ann Arbor, Mich. University Microfilms (n.d.) (American Culture Series, Reel 238.4)

Experimental enquiry concerning the natural powers of wind and water to turn mills and other machines depending on a circular motion. And An experimental examination of the quantity and proportion of mechanic power necessary to be employed in giving different degrees of velocity to heavy bodies from a state of rest. Also New fundamental experiments upon the collision of bodies. With five plates of machines.

Goldsmiths'-Kress no. 16657.1.