Medical conduct and practice; a guide to the ethics of medicine;

Mode of access: Internet.

Soil survey of the Coachella Valley area, California /

At head of title: U.S. Department of Agriculture, Bureau of Soils in cooperation with the University of California Agricultural Experiment Station.

The authority of doctrinal decisions which are not definitions of faith, considered in a short series of essays reprinted from "The Dublin review."

Mode of access: Internet.

The Blennerhassett papers, embodying the private journal of Harman Blennerhassett, and the hitherto unpublished correspondence of Burr, Alston, Comfort Tyler, Devereaux, Dayton, Adair, Miro, Emmett, Theodosia Burr Alston, Mrs. Blennerhassett, and others, their contemporaries; developing the purposes and aims of those engaged in the attempted Wilkinson and Burr revolution; embracing also the first account of the "Spanish association of Kentucky," and a memoir of Blennerhassett,

Mode of access: Internet.

Poole's index to periodical literature,

Editors: 1802/1881- , W. F. Poole and W. I. Fletcher.

Narrative of the life of Moses Grandy, formerly a slave in the United States of America.

Introduction signed and dated: George Thompson, 9, Blandford Place, Regent's Park, October 18th, 1842.

Sharpe's London magazine of entertainment and instruction for general reading

Mode of access: Internet.

The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch

The Raf-1 protein kinase is a major activator of the ERK MAPK pathway, which links signaling by a variety of cell surface receptors to the regulation of cell proliferation, survival, differentiation and migration. Signaling by Raf-1 is regulated by a complex and poorly understood interplay between phosphorylation events and protein-protein interactions. One important mode of Raf-1 regulation involves the phosphorylation-dependent binding of 14-3-3 proteins. Here, we have examined the mechanism whereby the C-terminal 14-3-3 binding site of Raf-1, S621, controls the activation of MEK-ERK signaling. We show that phosphorylation of S621 turns over rapidly and is enriched in the activated pool of endogenous Raf-1. The phosphorylation on this site can be mediated by Raf-1 itself but also by other kinase(s). Mutations that prevent the binding of 14-3-3 proteins to S621 render Raf-1 inactive by specifically disrupting its capacity to bind to ATP, and not by gross conformational alteration as indicated by intact MEK binding. Phosphorylation of S621 correlates with the inhibition of Raf-1 catalytic activity in vitro, but 14-3-3 proteins can completely reverse this inhibition. Our findings suggest that 14-3-3 proteins function as critical cofactors in Raf-1 activation, which induce and maintain the protein in a state that is competent for both ATP binding and MEK phosphorylation.

Franks family papers, 1711-1821, [1965-1968].

Contains business correspondence, accounts and documents relating to Jacob Franks of New York, his two sons, Moses and David, a nephew, Isaac, and a John Franks of Halifax, possibly a member of the family.

Ann Eliza Hepburne Rooth fonds, 1837-1897

Ann Eliza Hepburne was born in Chippawa, Ontario, in 1821, to William Hepburne and Susan Shannon. In 1842, she married William Anthony Rooth in St. James Cathedral in Toronto. They continued to live in different parts of the Niagara region, including Drummondville, Welland and Port Colborne. William was the editor and proprietor of the Drummondville Reporter, as well as an accountant and insurance agent, and later worked for the Customs Service in Port Colborne. He died in 1878, and Eliza in 1899. Both are buried in Drummond Hill Cemetery in Niagara Falls, Ontario.

Letter to William Dickson from Thomas Clark

Letter to William Dickson from Thomas Clark regarding Mr. Goring’s claims and Clark Street’s affair with Brackbill (1 ¼ pages, handwritten), June 15, 1821.

Indenture (vellum) of bargain and sale between William Dickson, Thomas Dickson and Thomas Clark

Indenture (vellum) of bargain and sale between William Dickson, Thomas Dickson and Thomas Clark, executors of the late Robert Hamilton of Queenston to George Moffat for land in Burford, Beverly and Grimsby, Ontario, Feb. 27, 1827.

Catalogue of the American library of the late Mr. George Brinley of Hartford, Conn. Containing also a biographical sketch of Mr. Brinley and an alphabetical index to the entire catalogue.

Price lists inserted.