Involvement of the ALL-1 gene in a solid tumor.

Translocations involving chromosome band 11q23, found in 5-10% of human acute leukemias, disrupt the ALL-1 gene. This gene is fused by reciprocal translocation with a variety of other genes in acute lymphoblastic and myelogenous leukemias, and it undergoes self-fusion in acute myeloid leukemias with normal karyotype or trisomy 11. Here we report an alteration of the ALL-1 gene in a gastric carcinoma cell line (Mgc80-3). Characterization of this rearrangement revealed a three-way complex translocation, involving chromosomes 1 and 11, resulting in a partial duplication of the ALL-1 gene. Sequencing of reverse transcription-PCR products and Northern blot analysis showed that only the partially duplicated ALL-1 gene was transcribed, producing an mRNA with exon 8 fused to exon 2. This report of ALL-1 gene rearrangement in a solid tumor suggests that ALL-1 plays a role in the pathogenesis of some solid malignancies. The absence of the normal transcript in this cell line, in association with the loss-of-heterozygosity studies on chromosome 11q23 seen in solid tumors, suggests that ALL-1 is involved in tumorigenesis by a loss-of-function mechanism.

Inactivation of Bcl-2 by phosphorylation.

The antiapoptosis potential of Bcl-2 protein is well established, but the mechanism of Bcl-2 action is still poorly understood. Using the phosphatase inhibitor okadaic acid or the chemotherapeutic drug taxol, we found that Bcl-2 was phosphorylated in lymphoid cells. Phospho amino acid analysis revealed that Bcl-2 was phosphorylated on serine. Under similar conditions, okadaic acid or taxol treatment led to the induction of apoptosis in these cells. Thus, phosphorylation of Bcl-2 seems to inhibit its ability to interfere with apoptosis. In addition, phosphorylated Bcl-2 can no longer prevent lipid peroxidation as required to protect cells from apoptosis.

Real Driving Emissions: analisi e sperimentazione di metodologie di selezione dei percorsi su strada e di definizione di cicli di laboratorio

La presente tesi si occupa di identificare la metodologia utilizzata per la definizione di percorsi Real Driving Emissions. Nel particolare sono stati individuati due percorsi, uno in piano, definite RDE Moderate Track ed uno in quota, definito RDE Extended Track. Si è anche eseguita una analisi dei cicli su banco a rulli NEDC e WLTC in ottica Real Driving Emissions.

Database of GPS data collected by surveys on seismic and volcanic areas of Sicily (Italy) from 1994 to 2013

This is a 20-year long database of GPS data collected by geodetic surveys carried out over the seismically and volcanically active eastern Sicily, for a total of more than 6300 measurements. Data have been convertedi nto the international ASCII compressed RINEX standard in order to be imported and processed by any GPS analysis software. Database is provided with an explorer software for navigating into the dataset by spatial (GIS) and temporal queries.

A feasibility study of a sealed safety monitor for trucks carrying LNG and other hazardous materials. Final report.

Energy Department, Office of Operational Safety Programs, Washington, D.C.

Inni /

University of Illinois bookplate: "From the library of Conte Antonio Cavagna Sangiuliani di Gualdana Lazelada di Bereguardo, purchased 1921".

Books reviewed,

John Clare.--Miss Mansfield's stories--A book-collector.--Editing Shakespeare.--William James's letters.--Baudelaire.--Keats.--Austin Doubsn's essays--Mr. George Moore's tapestry.--Andrew Marvell.--A dictionary.--Queen Victioria.--Henley.--A critic.--Mr. Gosse's criticisms.--The art of writing.--A metabiological Pentateuch.--Byron.--Mr. de la Mare's romance [Memoirs of a midget]--Croce on Shakespeare.--The poets and childhood.--The classics in translation.--Escapes.--Lord Rosebery's Miscellanies--Minor Carolines--Mediv̲al Englis poetry.--Mark Akenside.--William Collins--Herman Milville.--Stock phrases--The laureates.--Letters.--Glands.--A supplement to Whitman.--The elements of poetry.--The prospects of English.--Delicate details--Christopher Smart.

Discorso istorico intorno alla cappella de' signori Minutoli, sotto il titolo di S. Pietro Apostolo e di S. Anastasia Martire dentro il Duomo napoletano /

Signatures: pi²,²pi²,³pi²(-³pi2) A⁸ B-K⁴ L⁶.

Sonate G-Dur = Sol-majeur = G major : für viola und Klavier /

Mode of access: Internet.

I principi e gli effetti del sistema governativo delle Due Sicilie dal 1830 al 1848. Osservazioni filosofico-politiche.

Mode of access: Internet.

Brunetto Latini e Il pataffio /

Includes index.

Della fauella nobile d'Italia tomo sesto dell' origine, cagioni, e difference della lingua.

Le origine della volgar Toscana fauella, per M. Celso Cittadini. Delle Cagioni della lingua Toscana, di M. Benedetto Buonmattei. Trattato della vera origine e del processo, e nome della nostra lingua, scritto in volgar Sanese, per Celso Cittadini. Origine della lingua Fiorentina... di M. Pier Francesco Giambulari. Delle differenze della lingua, del Subasiano.

Delle relationi vniversali /

Edit 16,

Saggio di ricerche sulla pellagra /

Mode of access: Internet.