Erosividade das chuvas associada a períodos de retorno e probabilidade de ocorrência no estado do Rio de Janeiro

O conhecimento da erosividade das chuvas associada à probabilidade de ocorrência e ao período de retorno pode contribuir para o planejamento conservacionista de uma região, em médio e longo prazo. A fim de gerar informações para melhor utilizar modelos e controle da erosão, dados de chuvas de 30 séries pluviográficas e pluviométricas, abrangendo 25 municípios, entre 1933 e 2006, foram estudados quanto à adequação das séries e do cálculo da probabilidade de ocorrência teórica (P) e período de retorno (T) da erosividade das chuvas (EI30 e KE>25), para o Estado do Rio de Janeiro. Foi feita a espacialização do potencial erosivo associado aos períodos de retorno de 2, 5, 10, 20, 50 e 100 anos para todo o Estado. A erosividade anual média (EI30) ou fator R da USLE para qualquer localidade no Estado do Rio de Janeiro pode ser igualada ou superada pelo menos uma vez, em média, em um período de 1,8 a 2,1 anos, com faixa de 48,5 a 54,9 % de probabilidade de ocorrência teórica. As localidades que apresentam maior erosividade associada aos períodos de retorno estão situadas nas mesorregiões Metropolitanas e em partes das mesorregiões Sul e Centro Fluminense. Foi possível identificar de oito a 12 regiões homogêneas, quanto à distribuição espacial da erosividade associada aos períodos de retorno de dois para 100 anos no Estado. De modo geral, a maior variação da distribuição espacial da erosividade apresenta-se na faixa de período de retorno de dois a cinco anos.

Free inertial processes driven by Gaussian noise: Probability distributions, anomalous diffusion and fractal behavior

We study the motion of an unbound particle under the influence of a random force modeled as Gaussian colored noise with an arbitrary correlation function. We derive exact equations for the joint and marginal probability density functions and find the associated solutions. We analyze in detail anomalous diffusion behaviors along with the fractal structure of the trajectories of the particle and explore possible connections between dynamical exponents of the variance and the fractal dimension of the trajectories.

Generalized Langevin equations: Anomalous diffusion and probability distributions

We study the motion of a particle governed by a generalized Langevin equation. We show that, when no fluctuation-dissipation relation holds, the long-time behavior of the particle may be from stationary to superdiffusive, along with subdiffusive and diffusive. When the random force is Gaussian, we derive the exact equations for the joint and marginal probability density functions for the position and velocity of the particle and find their solutions.

On the role of kerato-epithelin in the pathogenesis of 5q31-linked corneal dystrophies.

PURPOSE: Recently, the authors identified a gene, BIGH3, in which different mutations cause a group of hereditary corneal dystrophies: lattice type I and IIIA (CDLI and CDLIIIA), granular Groenouw type I (CDGGI), Avellino (CDA), and Reis-Bücklers' (CDRB). All these disorders are characterized by the progressive accumulation of corneal deposits with different structural organization. Experiments were conducted to determine the role of kerato-epithelin (KE), the product of BIGH3, in the pathogenesis of the diseases. METHODS: KE-15 and KE-2, two rabbit antisera raised against peptides from the 69-364 and 426 - 682 amino acid regions of KE respectively, were used for immunohistology of the corneas obtained after keratoplasty in six CDLI patients, three CDGGI patients, and one CDA patient. RESULTS: The nonamyloid deposits observed in CDGGI stained intensively with KE-15 and KE-2, whereas the amyloid deposits in all analyzed CDLI corneas reacted to KE-2 but not to KE-15. In the CDA cornea, where amyloid and nonamyloid inclusions were present, positive staining with both antisera was observed. CONCLUSIONS: Pathologic amyloid and nonamyloid deposits observed in CDLI, CDGGI-, and CDA-affected corneas are caused by KE accumulation. Different staining patterns of amyloid and nonamyloid deposits observed with antibodies against the amino and carboxyl termini of KE suggest that two mechanisms of KE misfolding are implicated in the pathogenesis of 5q31-linked corneal dystrophies.

Alterations of Neuromuscular Function after the World's Most Challenging Mountain Ultra-Marathon

We investigated the physiological consequences of the most challenging mountain ultra-marathon (MUM) in the world: a 330-km trail run with 24000 m of positive and negative elevation change. Neuromuscular fatigue (NMF) was assessed before (Pre-), during (Mid-) and after (Post-) the MUM in experienced ultra-marathon runners (n = 15; finish time = 122.43 hours +/-17.21 hours) and in Pre- and Post- in a control group with a similar level of sleep deprivation (n = 8). Blood markers of muscle inflammation and damage were analyzed at Pre- and Post-. Mean +/- SD maximal voluntary contraction force declined significantly at Mid- (-13+/-17% and -10+/-16%, P<0.05 for knee extensor, KE, and plantar flexor muscles, PF, respectively), and further decreased at Post- (-24+/-13% and -26+/-19%, P<0.01) with alteration of the central activation ratio (-24+/-24% and -28+/-34% between Pre- and Post-, P<0.05) in runners whereas these parameters did not change in the control group. Peripheral NMF markers such as 100 Hz doublet (KE: -18+/-18% and PF: -20+/-15%, P<0.01) and peak twitch (KE: -33+/-12%, P<0.001 and PF: -19+/-14%, P<0.01) were also altered in runners but not in controls. Post-MUM blood concentrations of creatine kinase (3719+/-3045 Ul.1), lactate dehydrogenase (1145+/-511 UI.L-1), C-Reactive Protein (13.1+/-7.5 mg.L-1) and myoglobin (449.3+/-338.2 microg.L-1) were higher (P<0.001) than at Pre- in runners but not in controls. Our findings revealed less neuromuscular fatigue, muscle damage and inflammation than in shorter MUMs. In conclusion, paradoxically, such extreme exercise seems to induce a relative muscle preservation process due likely to a protective anticipatory pacing strategy during the first half of MUM and sleep deprivation in the second half.

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

A current paradigm proposes that mitochondrial damage is a critical determinant of NLRP3 inflammasome activation. Here, we genetically assess whether mitochondrial signalling represents a unified mechanism to explain how NLRP3 is activated by divergent stimuli. Neither co-deletion of the essential executioners of mitochondrial apoptosis BAK and BAX, nor removal of the mitochondrial permeability transition pore component cyclophilin D, nor loss of the mitophagy regulator Parkin, nor deficiency in MAVS affects NLRP3 inflammasome function. In contrast, caspase-8, a caspase essential for death-receptor-mediated apoptosis, is required for efficient Toll-like-receptor-induced inflammasome priming and cytokine production. Collectively, these results demonstrate that mitochondrial apoptosis is not required for NLRP3 activation, and highlight an important non-apoptotic role for caspase-8 in regulating inflammasome activation and pro-inflammatory cytokine levels.

Pirosi: avete la scelta per la presa a carico a breve termine!: revisione Cochrane per il medico di famiglia.

Cet article présente les résultats de la revue systématique: van Pinxteren B, Sigterman KE, Bonis P, Lau J, Numans ME. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease. Cochrane Database of Systematic Reviews 2010, Issue 11, Art. No.: CD002095. DOI: 10.1002/14651858.CD002095.pub4. PMID: 21069670.

4-6-vuotiaan leikki-ikäisen lapsen selviytymiskeinot kivusta

Opinnäytetyön tarkoituksena on kartoittaa systemaattista kirjallisuuskatsausta soveltaen, millaisia konkreettisia kivusta selviytymiskeinoja 4-6 -vuotias leikki-ikäinen lapsi käyttää. Työn pääpaino on ei-lääkkeellisissä keinoissa, vaikka lääkkeellisiä selviytymiskeinojakaan ei voitu täysin karsia pois aineistosta. Työn keskeisimmät käsitteet "selviytymiskeinot", "kipu" ja "4-6 -vuotias lapsi" on avattu teoriaosuudessa. Opinnäytetyö kuuluu viisi-vuotiseen Lapsen pelon ja kivun hoitotyön tutkimus- ja ke-hittämishankkeeseen. Hankkeella pyritään kehittämään 2 - 6 -vuotiaiden lasten pelon ja kivun hoitotyötä tieteen, taiteen ja koulutuksen avulla. ”Musiikki ja draama lapsen pelon ja kivun lievittäjänä” -projektin yhteistyökumppaneita ovat Helsingin ammattikorkeakoulu Stadian taiteen ja viestinnän yksikkö sekä sosiaali- ja terveysalan yksikkö, Turun yliopiston hoitotieteen laitos sekä HUS Lasten ja nuorten sairaala. Työ soveltaa systemoidun kirjallisuuskatsauksen menetelmää. Aineisto hankittiin Nelliportaalin avulla tehdyillä hauilla. Aineisto koostuu kahdeksasta englanninkielisestä tutkimusartikkelista ja se analysoitiin induktiivisella sisällönanalyysillä. Analyysin tuloksena oli seitsemän yläluokkaa: toiminta, sosiaalinen tuki, fyysiset rentoutumismenetelmät, viihde, tiedonsaanti, psykologiset keinot ja kivunhoito. Työn tulokset ovat saman suuntaisia kuin aikaisempien tutkimusten ja opinnäytetöiden tulokset. Kirjallisuuskatsauksen perusteella voi todeta , että vanhempien roolia lapsen selviytymisessä on tutkittu melko laajasti, mutta lapsen näkökulma ja spesifinen tutkimustieto 4 - 6 -vuotiaan lapsen selviytymisestä on vähäisempää. Työn tulokset antavat hyvän perustan selviytymiskeinojen käytölle hoitotyössä, vaikka niitä ei voikaan suoraan soveltaa suomalaiseen lastenhoitotyöhön. Työn tuloksia tulisi testata käytännössä 4 - 6 -vuotiailla suomalaislapsilla, ennen kuin voi lähteä muuttamaan hoitotyön käytäntöjä.