960 resultados para Blast furnace slag
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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O artigo analisa o processo de instalação, na Amazônia Oriental brasileira, de diversos produtores independentes de ferro-gusa, nas últimas duas décadas. Mesmo em número e velocidade menores do que indicava o planejamento estatal, foram implantadas no Corredor da Estrada de Ferro Carajás doze siderúrgicas. São empresas dedicadas somente à produção desta commoditie cuja produção requer elevada quantidade de energia suprida por carvão vegetal. Neste artigo, mostramos que houve deslocamento para a Amazônia de indústrias que até os anos 90 estavam concentradas exclusivamente no Sudeste brasileiro e que a demanda de carvão vegetal consolidou-se como principal elo de articulação da siderurgia com a socioeconomia da região de Carajás. A produção de carvão vegetal tem acarretado muitos impactos sociais e ambientais na região Amazônica. Impactos que se materializam pela ampliação da pressão exercida sobre a floresta amazônica, por práticas ambientalmente imprudentes e pela produção do carvão vegetal sustentada por trabalho precário, mal remunerado e insalubre. Exemplo de um cenário diante do qual se desenha como alternativa é a manutenção da fabricação de ferro-gusa nos moldes atuais e a incorporação de pequenos fornos elétricos a arco para a produção de aço. Contudo, a possível instalação de mini-aciarias na região, por si só, não resolve o principal problema socioambiental que envolve o beneficiamento do minério de ferro na região, vinculado aos efeitos deletérios da produção carvoeira, podendo inclusive agravá-los.
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Conditioned suppression is an animal model of anxiety disorders that has been broadly used to investigate the behavioral effects of different drugs. However, various methodological variables (e.g., the type of aversive stimulus) that supposedly interfere with the acquisition of conditioned suppression may also contribute to conflicting results among the studied drugs. Additionally, few studies have sought to investigate the effects of selective serotonin reuptake inhibitors (SSRIs). The present study investigated the effect of subchronic 5-day administration of 5 mg/kg fluoxetine in the retention of conditioned suppression produced by a hot air blast (HAB). The subjects were 12 albino Wistar rats distributed into an Experimental Group (EG) and Control Group (CG). After sessions were conducted to pair two stimuli, a sound and HAB, fluoxetine (EG) or saline (CG) was administered. Twentyfour hours after the last injection, a test session was conducted. The results showed no difference between groups. Fluoxetine (5 mg/kg) did not exert anxiolytic effects in this model of conditioned suppression produced by a HAB. Keywords: conditioned suppression; fluoxetine; subchronic; hot air blast.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Blast traumatic brain injury (BTBI) has become an important topic of study because of the increase of such incidents, especially due to the recent growth of improvised explosive devices (IEDs). This thesis discusses a project in which laboratory testing of BTBI was made possible by performing blast loading on experimental models simulating the human head. Three versions of experimental models were prepared – one having a simple geometry and the other two having geometry similar to a human head. For developing the head models, three important parts of the head were considered for material modeling and analysis – the skin, skull and brain. The materials simulating skin, skull and brain went through many testing procedures including dynamic mechanical analysis (DMA). For finding a suitable brain simulant, several materials were tested under low and high frequencies. Step response analysis, rheometry and DMA tests were performed on materials such as water based gels, oil based mixtures and silicone gels cured at different temperatures. The gelatins and silicone gels showed promising results toward their use as brain surrogate materials. Temperature degradation tests were performed on gelatins, indicating the fast degradation of gelatins at room temperature. Silicone gels were much more stable compared to the water based gels. Silicone gels were further processed using a thinner-type additive gel to bring the dynamic modulus values closer to those of human brain matter. The obtained values from DMA were compared to the values for human brain as found in literature. Then a silicone rubber brain mold was prepared to give the brain model accurate geometry. All the components were put together to make the entire head model. A steel mount was prepared to attach the head for testing at the end of the shock tube. Instrumentation was implemented in the head model to obtain effective results for understanding more about the possible mechanisms of BTBI. The final head model was named the Realistic Explosive Dummy Head or the “RED Head.” The RED Head offered potential for realistic experimental testing in blast loading conditions by virtue of its material properties and geometrical accuracy.
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Chronic myelogenous leukemia (CML) is a common myeloproliferative disease that is characterized by the clonal expansion of marrow stem cells, and is associated with the Philadelphia chromosome. As the disease progresses, additional chromosome abnormalities may arise. The prognostic impact of secondary chromosomal abnormalities in CML is complex, heterogeneous, and sometimes related to previous treatment. Here, we describe a CML patient in lymphoid blast crisis associated with a new chromosomal abnormality identified, dic(7;12)(p12.21;p12.2) and i(12)(q10) using classical cytogenetics and spectral karyotype analysis. To the best of our knowledge, this is the first report of t(7;12)(p11.1;q11.1) and i(12)(q10) in a CML patient with lymphoid evolution.
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Determination of chlorine using the molecular absorption of aluminum mono-chloride (AlCl) at the 261.418 nm wavelength was accomplished by high-resolution continuum source molecular absorption spectrometry using a transversely heated graphite tube furnace with an integrated platform. For the analysis. 10 mu L of the sample followed by 10 mu L of a solution containing Al-Ag-Sr modifier, (1 g L-1 each), were directly injected onto the platform. A spectral interference due to the use of Al-Ag-Sr as mixed modifier was easily corrected by the least-squares algorithm present in the spectrometer software. The pyrolysis and vaporization temperatures were 500 degrees C and 2200 degrees C, respectively. To evaluate the feasibility of a simple procedure for the determination of chlorine in food samples present in our daily lives, two different digestion methods were applied, namely (A) an acid digestion method using HNO3 only at room temperature, and (B) a digestion method with Ag, HNO3 and H2O2, where chlorine is precipitated as a low-solubility salt (AgCl), which is then dissolved with ammonia solution. The experimental results obtained with method B were in good agreement with the certified values and demonstrated that the proposed method is more accurate than method A. This is because the formation of silver chloride prevented analyte losses by volatilization. The limit of detection (LOD, 3 sigma/s) for Cl in methods A and B was 18 mu g g(-1) and 9 mu g g(-1), respectively, 1.7 and 3.3 times lower compared to published work using inductively coupled plasma optical emission spectrometry, and absolute LODs were 2.4 and 1.2 ng, respectively. (C) 2012 Elsevier B.V. All rights reserved.
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Uppsatsen är en kvalitativ studie som studerar hur vuxna påverkats av att ha blivit mobbade som barn. Studien byggde på åtta halvstrukturerade intervjuer där vi sökte individernas tidigare upplevelser. Personer med denna bakgrund och som är över 20 år har nåtts genom annonsering och via mail. Materialet är avgränsat till att gälla forskning om familjestruktur och identitetsbildning. I vårt resultat har vi redovisat våra intervjupersoners egna erfarenheter av sina upplevelser och analyserat dessa i relation till litteraturer, artiklar och avhandlingar. I arbetet använder vi bl.a. Olweus definition av mobbning samt Colorosos begrepp murfamiljen och geléfamiljen. Resultatet av intervjuerna visar att mobbning i barndomen har påverkat deras vuxna liv. Samtliga känner att de har idag svårt att lita på folk och skapa nya kontakter. Studien visar också att samtliga har haft problem med självkänsla och identitetsbildning i form av att de har känt sig ensamma, utfrysta, kränkta och utanför. Detta har bland annat skapat en känsla av att inte räcka till och inte duga som man är. En annan slutsats som studien visar är att familjeförhållanden och uppfattning av ens egen identitet är två viktiga faktorer när det gäller mobbning. Studien visar att brister på åtgärder från skolan och socialvård förekommer. Konkret behandling och stöd av lärare, kontakt med kurator och bättre hemförhållanden hade på ett tidigt stadium kunnat förbättra deras situation.
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Kinetic investigations in pediatric acute lymphoblastic leukemia (ALL) are based on all blast cells and, therefore, reflect the proliferative characteristics of the predominant immunophenotype of leukemic cells. Nothing is known about proliferation of immunologically defined rare subpopulations of leukemic cells. In this study, mononuclear cells from the bone marrow of 15 children with untreated CD19 B-cell precursor ALL were examined for proliferative features according to the immunophenotype. After exclusion of highly proliferating residual normal hematopoietic cells, ∼ 3% of blast cells were CD19 and showed a low percentage of cells in S-phase assessed by the bromodeoxyuridine labeling index (BrdU-LI): median BrdU-LI, 0.19% [interquartile range (IQR), 0.15-0.40%]. In contrast, a median BrdU-LI of 7.2% (IQR, 5.7-8.8%) was found for the major CD19 blast cell compartment. Staining smears of sorted CD19 cells for CD10 or CD34 revealed a small fraction of CD19CD10 or CD19CD34 blast cells. These cells were almost nonproliferating with a median BrdU-LI of <0.1% (IQR, 0-0.2%). This proliferative behavior is suggestive of a stem/progenitor cell function and, in addition, the low proliferative activity might render them more resistant to an antiproliferation-based chemotherapy. However, xenotransplantation experiments will be necessary to demonstrate a possible stem cell function.