Hierarchical self-assembly of the DNA-grafted supramolecular polymers

Conjugation of functional entities with a specific set of optical, mechanical or biological properties to DNA strands allows engineering of sophisticated DNA-containing architectures. Among various hybrid systems, DNA-grafted polymers occupy an important place in modern materials science. In this contribution we present the non-covalent synthesis and properties of DNA-grafted linear supramolecular polymers (SPs), which are assembled in a controllable manner from short chimeric DNA-pyrene oligomers. The synthetic oligomers consist of two parts: a 10 nucleotides long DNA chain and a covalently attached segment of variable number of phosphodiester-linked pyrenes. The temperature-dependent formation of DNA-grafted SPs is described by a nucleation-elongation mechanism. The high tendency of pyrenes to aggregate in water, leads to the rapid formation of SPs. The core of the assemblies consists of stacked pyrenes. They form a 1D platform, to which the DNA chains are attached. Combined spectroscopic and microscopic studies reveal that the major driving forces of the polymerization are π-stacking of pyrenes and hydrophobic interactions, and DNA pairing contributes to a lesser extent. AFM and TEM experiments demonstrate that the 1D SPs appear as elongated ribbons with a length of several hundred nanometers. They exhibit an apparent helical structure with a pitch-to-pitch distance of 50±15 nm. Since DNA pairing is a highly selective process, the ongoing studies are aimed to utilize DNA-grafted SPs for the programmable arrangement of functional entities. For example, the addition of non-modified complementary DNA strands to the DNA-grafted SPs leads to the cooperative formation of higher-order assemblies. Also, our experiments suggest that the fluorescent pyrene core of 1D ribbons serves as an efficient donor platform for energy transfer applications.

Tubes or sheets: divergent aggregation pathways of an amphiphilic 2,7-substituted pyrene trimer

The self-assembly of an amphiphilic 2,7-linked pyrene trimer in an aqueous environment into two morphologically related forms is described. Supramolecular polymerization leads to the simultaneous formation of nanosheets and nanotubes.

An iPhone-based application for promoting type 2 diabetic patients self- management towards healthy lifestyle habits

— In 2000, according to the World Health Organization, at least 171 million people, 2.8% of the population worldwide, suffered from diabetes. The Centres for Disease Control has defined it as an epidemic disease. Its incidence is increasing rapidly, and it is estimated that by 2030 this number will almost double. Diabetes mellitus occurs throughout the world, but is more common (especially type 2) in the more developed countries. Diabetes is a chronic condition that occurs when pancreas does not assure enough insulin secretion or when the body does not consume the insulin produced. Insulin is a hormone that regulates blood sugar. The effect of uncontrolled diabetes is the hyperglycaemia (blood sugar), which eventually seriously damage many organs and systems, especially the nerves and blood vessels. Diabetes type 2 (most common type of diabetes) is highly correlated with elderly people, obesity or overweight. Promoting a healthy lifestyle helps patients to improve their quality of life and in many cases to avoid complications related to the disease. This paper is intended to describe an iPhone-based application for self-management of type 2 diabetic patients, which allow them improving their lifestyle through healthy diet, physical activity and education

Ab-Initio calculations including Van der Waals interactions: the SnS2 layered material

Tin disulfide SnS2 was recently proposed as a high efficiency solar cell precursor [1]. The aim of this work is a deep study of the structural disposition of the most important polytipes of this layered material, not only describing the electronic correlation but also the interatomic Van der Waals interactions that is present between the layers. The two recent implementations to take Van der Waals interactions into account in the VASP code are the self-consistent Dion et al. [2] functional optimized for solids by Michaelides et al [3] and the Grimme [4] dispersion correction that is applied after each autoconsistent PBE electronic calculation. In this work these two methods are compared with DFT PBE functional. The results we will presented at this Conference, demonstrates the enhancement of the geometric parameters by the use of the Van der Waals interactions in agreement with the experimental values.

Besser allein als gemeinsam einsam? Schottland stimmt über seine Unabhängigkeit ab = Flashlight Europe No. 2, September 2014: Scotland Is Voting On Whether Or Not To Become Independent

No abstract.

Highway traffic safety self-instruction course: module 2 workbook - highway safety standards.

National Highway Traffic Safety Administration, Washington, D.C.

Financial self-sufficiency study and guidelines. Volume 2: funding matrix and summaries of state programs.

Mode of access: Internet.

Iac. Bontii ... De medicina Indoru[m] lib. IV. : I. Notæ in Garciam ab Orta. 2. De diæta sanorum. 3. Meth. medendi Indica. 4. Observationes e cadaveribus.

Mode of access: Internet.

Isagoge In notitiam scriptorum historiae gallicae qua continetur 1. Andreae Du Chesne Bibliotheca chronologica scriptorum ab originibus regni Francici ... 2. Christiani Gryphii Scriptorum saeculi 17. de rebus Gallicis 3. Herm. Diet. Meibomii De Gallicae historiae periodis & scriptoribus dissertatio. ... Selegit atqve junctim edidit Albertus Fabricius

"Christiani Gryphi V.C. Diatribe de scriptoribus rerum Galliae et Lotharingiae, seculi praesertim XVII" y "Hermanni Dieterici Meibomii De Gallicae Historiae periodis ac praecipuis scriptoribus dissertatio. Edita Helmstadii a. 1703" con portadillas, pag. y sign. propias.

Workmen's compensation insurance, State of New York ... : four plans of insurance : 1. State fund, 2. Mutual association, 3. Self-insurance, 4. Stock insurance ... /

Mode of access: Internet.

Ogygia: seu, Rerum Hibernicarum chronologia. : Ex pervetustis monumentis fideliter inter se collatis eruta, atque è sacris ac prophanis literis primarum orbis gentium tam genealogicus, quam chronologicis sufflaminata præsidiis. : Liber primus. Ab universali diluvio, ad annum Virginei partus 428 ... : Quibus accedit, regum Hiberniæ Christianorum ab anno 428 ad annum 1022; aliorumque eventuum inde ad jam regnantem Carolum 2 brevis chronologica tabula. : Deinde carmen chronographicum summam omnium à diluvio ad præsens tempus complectens. : Postremò catalogus regum in Britannia Scotorum, ex Hiberniæ monumentis. /

Pages [2] and [16], first sequence, and [60] and [511]-[512], third sequence, are blank.

Organizational and direct support, repair parts, and special tools list for drill, pneumatic, drifter, crawler mounted, self propelled, dry type, 220 lb class, minimum 4-1/2 inch bore, power feed, 1-1/2 inch lugged shank chuck w/ 12 each [sic] shank rock drill (Chicago Pneumatic Tool Company model G-900) (NSN 3820-00-930-1917).

"May 1976."

Organizational, direct and general support maintenance repair parts and special tools list : air conditioner, wall or base mounted, air cooled, self contained, electric motor driven, 6,000 BTU/hr, 115v, 1 phase, 2 wire, 50/60 Hertz (Therm-air model CE-6A-60A2), FSN 4120-476-9249.

Includes index.