Prévention du syndrome post-thrombotique [Prevention of post-thrombotic syndrome].

Post-thrombotic syndrome (PTS) is the most frequent chronic complication of deep vein thrombosis (DVT) with an estimated prevalence of 30-50%. PTS is a significant cause of disability, especially when complicated by venous ulcers. Therefore, PTS has important socio-economic consequences for both the patient and the health care system. Actually, the efficacy of PTS treatment is very limited; therefore, best treatment remains prevention. Compression therapy, particularly by graduated compression stockings (GCS) has a pivotal role in PTS prophylaxis. Aim of this article is to resume state of the art literature on this subject. Recommendations on PTS prevention have even been reported.

Training in flexible intensive insulin therapy improves quality of life, decreases the risk of hypoglycaemia and ameliorates poor metabolic control in patients with type 1 diabetes.

AIM: Intensified insulin therapy has evolved to be the standard treatment of type 1 diabetes. However, it has been reported to increase significantly the risk of hypoglycaemia. We studied the effect of structured group teaching courses in flexible insulin therapy (FIT) on psychological and metabolic parameters in patients with type 1 diabetes. METHODS: We prospectively followed 45 type 1 diabetic patients of our outpatient clinic participating in 5 consecutive FIT teaching courses at the University Hospital of Basel. These courses consist of 7 weekly ambulatory evening group sessions. Patients were studied before and 1, 6, and 18 months after the course. Main outcome measures were glycated haemoglobin (HbA1c), severe hypoglycaemic events, quality of life (DQoL), diabetes self-control (IPC-9) and diabetes knowledge (DWT). RESULTS: Quality of life, self-control and diabetes knowledge improved after the FIT courses (all p<0.001). The frequency of severe hypoglycaemic events decreased ten-fold from 0.33 episodes/6 months at baseline to 0.03 episodes/6 months after 18 months (p<0.05). Baseline HbA1c was 7.2+/-1.1% and decreased in the subgroup with HbA1c > or = 8% from 8.4% to 7.8% (p<0.05). CONCLUSIONS: In an unselected, but relatively well-controlled population of type 1 diabetes, a structured, but not very time consuming FIT teaching programme in the outpatient setting improves psychological well-being and metabolic parameters.

Processo de Recrutamento e Selecção de Pessoal nos Municípios Cabo-verdianos: O Caso de São Domingos

O Presente trabalho intitulado “Processo de Recrutamento e Selecção de Pessoal nos Municípios Cabo-verdianos: O Caso de São Domingos”, enquadra-se no âmbito do curso de licenciatura em Administração Pública e Autárquica ministrado pela Universidade Jean Piaget de Cabo Verde. Este estudo aborda a gestão de pessoas e a inter-relação com a contratação dos colaboradores. Descreve os subsistemas da gestão de pessoas e a contribuição dos mesmos no alcance da missão da organização. A gestão de recursos humanos assume uma importância crescente nas organizações. Os colaboradores deixaram de ser vistos como meros recursos, para se tornarem fonte de vantagem competitiva. O recrutamento e selecção de pessoal destacam-se como procedimentos–chave, dado que é por seu intermédio que os trabalhadores acedem àsorganizações. O objectivo deste trabalho consiste em analisar a importância do processo de recrutamento e selecção de pessoal na aquisição do potencial humano na CMSD, ressaltando as suas vantagens e inconveniências. A metodologia adoptada, para além de outras, baseou-se no estudo de caso. Neste sentido, analisou-se uma instituição na qual foi aplicada um inquérito por questionário, Em termos de resultados finais de investigação, concluiu-se o recrutamento e selecção de pessoal da CMSD fazem-se de acordo com os preceitos legais vigentes na Administração Pública e com base no uso de métodos e técnicas adequados. Ficou evidente a necessidade de se investir nos recursos humanos, de forma a garantir uma gestão eficaz. O recrutamento garante pessoas engajadas e comprometidas com o ideal organizacional e podem também influenciar a forma de competir e buscar resultadosdesejados pela organização

Investigación de crustáceos de profundidad en la zona de Pisco - Callao

Entre el 14 y 27 de diciembre del 2005, se efectuó el crucero de investigación de crustáceos de profundidad a bordo del BIC Imarpe VI. Se realizaron 14 lances entre 12°S y 15°S y en dos estratos de profundidad (A: 700-1000 m, B: 1000-1400 m). Las operaciones de pesca se realizaron durante el día. En los experimentos de captura fueron utilizados diferentes tipos de mallas, carnadas y color de la boca de entrada de la nasa. Se registraron 4 especies: Paralomis longipes, Lithodes wiracocha, Lithodes panamensis y Lopholithodes diomedeae, siendo la de mayor incidencia Paralomis longipes. Se capturaron un total de 327 ejemplares con 305 kg. Los mayores rendimientos se registraron en el estrato B en 14°S y se encontraron los mayores tamaños de P. longipes, sin embargo, Lithodes panamensis alcanzó mayores tamaños que P. longipes. La proporción sexual fue favorable a machos. Las hembras de P. longipes en su mayoría portaban huevos. Se observó y estimó la incidencia de parásitos rizocefalos, epibiontes y la frecuencia de muda.

Evaluación de bancos naturales de “palabritas” (Donax spp.) en el litoral de Lambayeque, 2010.

En marzo y junio 2010, se efectuaron evaluaciones poblacionales del recurso Donax spp., entre El Palo y playa La Punta del litoral de Lambayeque. La talla fluctuó entre 5 y 32 mm (marzo) y 7 a 33 mm (junio). La madurez gonadal en hembras en marzo, mostró el predominio de madurez total (24,35%), y en junio predominaron en estadio de evacuación parcial (22,2%) y evacuación total (18,9%). La densidad media en marzo varió entre 5,00 y 243,74 ind.m-2, encontrándose mayor concentración en El María y mayor dispersión en Playa Monsefú; en junio fluctuó entre 9,19 y 80,48 ind.m-2 con mayor concentración en El María. En marzo la población estimada fue 329,22 millones de individuos ± 27,96% y biomasa 702,24 t ± 27,94%; en junio fue 229,20 millones de individuos ± 32,69% y biomasa 577,27 t ± 31,91%. En marzo una mayor abundancia se registró en El María (110,90 millones de individuos) y Bodegones (81,28 millones de individuos), en junio El Gigante (50,83 millones de ejemplares) y El María (46,28 millones de ejemplares).

Apport de l'angiographie au vert d'indocyanine (ICG) dans la localisation des néovascularisations chororoidiennes occultes [Value of indocyanine green angiography in localization of occult choroid neovascularization]

PURPOSE: To determine the role of Indocyanin Green (ICG) angiography in localizing occult new vessels associated with age-related macular degeneration (ARMD) and assess the possibilities of ICG guided laser photocoagulations. PATIENTS AND METHODS: Fluorescein and ICG angiographies (IMAGEnet system) of 62 patients with occult new vessels (ONV), serous (SPED) or vascular (VPED) pigment epithelium detachment have been studied. RESULTS: Based on fondoscopic examination and fluorescein angiography, 43 eyes (69%) disclosed ONV, 8 (13%) SPED and 11 (18%) VPED. Choroidal neovascularisation was confirmed by ICG angiography in 37 ONV cases (86%), in 8 (72%) VPED cases, but in no SPED. Conversion of ONV in classical neovascular membranes was possible in 19 ONV cases (44%) and in 6 (54%) VPED cases, making a laser photocoagulation possible in 9 eyes (36%). CONCLUSION: ICG angiography plays an important role in the evaluation, classification and laser treatment of patients with ONV secondary to ARMD.

Microsatellite variation reveals low genetic subdivision in a chromosome race of Sorex araneus (Mammalia, Insectivora)

Two hundred and forty-five individuals of the common shrew (Sorex araneus, Insectivora, Mammalia) from 24 sampling localities situated in four different valleys of the western European Alps were genotyped for six microsatellite loci. Allelic variability ranged from 3 to 32 different alleles at a single locus and the average gene diversity over all loci was 0.69. An analysis for F and R statistics revealed weak genetic population subdivision (Fst = 0.032; Rst = 0.016). This suggests considerable gene flow and little phylogeographic structure within and between valleys. We tested whether a stepwise mutation model (SMM) better explained variation at the microsatellite loci than an infinite allele model (IAM). No trend in favor of either model was detected.

Loss of Memo, a novel FGFR regulator, results in reduced lifespan.

Memo is a widely expressed 33-kDa protein required for heregulin (HRG)-, epidermal growth factor (EGF)-, and fibroblast growth factor (FGF)-induced cell motility. Studies in mouse embryonic fibroblasts, wild-type or knockout for Memo, were performed to further investigate the role of Memo downstream of FGFR. We demonstrated that Memo associates with the FGFR signalosome and is necessary for optimal activation of signaling. To uncover Memo's physiological role, Memo conditional-knockout mice were generated. These animals showed a reduced life span, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, and loss of spermatozoa in the epididymis. Memo-knockout mice also have elevated serum levels of active vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D), and calcium compared to control littermates expressing Memo. In summary, the results from in vivo and in vitro models support the hypothesis that Memo is a novel regulator of FGFR signaling with a role in controlling 1,25(OH)2D production and normal calcium homeostasis.