Der malech Refael : in diezen seifer izṭ baišribin alle wichṭigsṭi segules tzu allerlei krankheiṭin ; fun di feršidene heilige tzadikim ; oich refues u-segules

[Jehuda Rosenberg]

Unmoral im Talmud : mit einer Einleitung und Erläuterungen

von Alfred Rosenberg

Relating orogen width to shortening, erosion, and exhumation during Alpine collision

We investigate along-strike width changes of the thickened, accreted lower plate (TALP) in the Central and in the Eastern Alps. We set the width of the TALP in relation to the inferred amount of collisional shortening and exhumation along six orogen-scale cross sections. Taking the present-day, along-strike gradients in the amount of collisional shortening to represent the temporal evolution of the collisional wedge, it may be concluded that the cross-sectional area of the TALP diminishes during ongoing shortening, indicating that the erosional flux outpaced the accretionary flux. Higher amounts of collisional shortening systematically coincide with smaller widths of the TALP and dramatic increases of the reconstructed eroded rock column. Higher amounts of shortening also coincide with larger amplitudes of orogen-scale, upright folds, with higher exhumation and with higher exhumation rates. Hence, erosion did play a major role in reducing by >30 km the vertical crustal thickness in order to accommodate and allow shortening by folding. Long-term climate differences cannot explain alternating changes of width by a factor of almost 2 along straight segments of the orogen on length scales less than 200 km, as observed from the western Central Alps to the easternmost Eastern Alps. Sedimentary or paleontological evidences supporting such paleo-climatic differences are lacking, suggesting that erosional processes did not directly control the width of the orogen.

Tseʾenah u-reʾenah : ʿal ḥamishah ḥumshe torah ...

fun Yitsḥaḳ mi-ḳ. ḳ. Yanoṿ. ʿIm Shelah ha-ḳadosh ṿe-ʿim Sefer ha-Yashar ṿe-Sefer Ohel Yaʿaḳov fun Yaʿaḳov mi-Dubno ...

Ueber eine Sammlung deutscher Volks- und Gesellschaftslieder in hebräischen Lettern

Felix Rosenberg

VE1 immunohistochemistry predicts BRAF V600E mutation status and clinical outcome in colorectal cancer

AIM VE1 is a monoclonal antibody detecting mutant BRAFV600E protein by immunohistochemistry. Here we aim to determine the inter-observer agreement and concordance of VE1 with mutational status, investigate heterogeneity in colorectal cancers and metastases and determine the prognostic effect of VE1 in colorectal cancer patients. METHODS Concordance of VE1 with mutational status and inter-observer agreement were tested on a pilot cohort of colorectal cancers (n = 34), melanomas (n = 23) and thyroid cancers (n = 8). Two prognostic cohorts were evaluated (n = 259, Cohort 1 and n = 226, Cohort 2) by multiple-punch tissue microarrays. VE1 staining on preoperative biopsies (n = 118 patients) was compared to expression in resections. Primary tumors and metastases from 13 patients were tested for VE1 heterogeneity using a tissue microarray generated from all available blocks (n = 100 blocks). RESULTS Inter-observer agreement was 100% (kappa = 1.0). Concordance between VE1 and V600E mutation was 98.5%. Cohort 1: VE1 positivity (seen in 13.5%) was associated with older age (p = 0.0175) and MLH1 deficiency (p < 0.0001). Cohort 2: VE1 positivity (seen in 12.8%) was associated with female gender (p = 0.0016), right-sided tumor location (p < 0.0001), higher tumor grade (p < 0.0001) and mismatch repair (MMR)-deficiency (p < 0.0001). In survival analysis, MMR status and postoperative therapy were identified as possible confounding factors. Adjusting for these features, VE1 was an unfavorable prognostic factor. Preoperative biopsy staining matched resections in all cases except one. No heterogeneity was found across any primary/metastatic tumor blocks. CONCLUSION VE1 is highly concordant for V600E and homogeneously expressed suggesting staining can be analysed on resection specimens, preoperative biopsies, metastatic lesions and tissue microarrays.

[Rezension]

Manfred Rosenberg

Ueber eine Sammlung deutscher Volks- und Gesellschaftslieder in hebräischen Lettern : (Schluss)

Felix Rosenberg

Jacob Gerzon [Rezension]

F. Rosenberg

Oskar Frankl [Rezension]

F. Rosenberg

Studie [Illustration]

Lazar Rosenberg

Jüdischer Greis [Illustration]

Lazar Rosenberg

Studie [Illustration]

Lazar Rosenberg

Schlafender Knabe [Illustration]

Lazar Rosenberg

Kauerndes Mädchen [Illustration]

Lazar Rosenberg