The Hugh Sinclair Unit of Human Nutrition – 20 years of research 1995–2015

The Hugh Sinclair Unit of Human Nutrition (HSUHN) at the University of Reading was founded in October 1995 with the appointment of Christine Williams OBE as the first Hugh Sinclair Chair in Human Nutrition. This was made possible by the competitively won funds from the estate and legacy of the late Professor Hugh Macdonald Sinclair (1910–1990). The vision for the newly established HSUHN was to ‘strengthen the evidence base for dietary recommendations for prevention of degenerative chronic diseases’. This has remained the research focus of the HSUHN under the leadership of Professors Christine Williams (1995–2005), Ian Rowland (2006–2013) and Julie Lovegrove (2014-present). Our mission is to improve population health and evaluate mechanisms of action for the effects of dietary components on health, which reflects Hugh Sinclair’s life ambition within nutritional science. Over the past 20 years, the HSUHN has developed an international reputation within the nutrition science community, and in recognition of the 20th anniversary, this paper highlights Hugh Sinclair’s contributions to the field of nutrition and key research achievements by members of the Unit.

Breaking the double-edged sword of effort/trying hard: developmental equilibrium and Longitudinal relations among effort, achievement, and academic self-concept

Ever since the classic research of Nicholls (1976) and others, effort has been recognized as a double-edged sword: whilst it might enhance achievement, it undermines academic self-concept (ASC). However, there has not been a thorough evaluation of the longitudinal reciprocal effects of effort, ASC and achievement,in the context of modern self-concept theory and statistical methodology. Nor have there been developmental equilibrium tests of whether these effects are consistent across the potentially volatile early-to-middle adolescence. Hence, focusing on mathematics, we evaluate reciprocal effects models over the first four years of secondary school, relating effort, achievement (test scores and school grades), ASC, and ASCxEffort interactions for a representative sample of 3,421 German students (Mn age = 11.75 years at Wave 1). ASC, effort and achievement were positively correlated at each wave, and there was a clear pattern of positive reciprocal positive effects among ASC, test scores and school grades—each contributing to the other, after controlling for the prior effects of all others. There was an asymmetrical pattern of effects for effort that is consistent with the double-edged sword premise: prior school grades had positive effects on subsequent effort, but prior effort had non-significant or negative effects on subsequent grades and ASC. However, on the basis of a synergistic application of new theory and methodology, we predicted and found a significant ASC-by-effort interaction, such that prior effort had more positive effects on subsequent ASC and school grades when prior ASC was high—thus providing a key to breaking the double-edged sword.

The Genetics of Alzheimer`s Disease in Brazil: 10 Years of Analysis in a Unique Population

Alzheimer`s Disease (AD) is the most common type of dementia among the elderly, with devastating consequences for the patient, their relatives, and caregivers. More than 300 genetic polymorphisms have been involved with AD, demonstrating that this condition is polygenic and with a complex pattern of inheritance. This paper aims to report and compare the results of AD genetics studies in case-control and familial analysis performed in Brazil since our first publication, 10 years ago. They include the following genes/markers: Apolipoprotein E (APOE), 5-hidroxytryptamine transporter length polymorphic region (5-HTTLPR), brain-derived neurotrophin factor (BDNF), monoamine oxidase A (MAO-A), and two simple-sequence tandem repeat polymorphisms (DXS1047 and D10S1423). Previously unpublished data of the interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) genes are reported here briefly. Results from others Brazilian studies with AD patients are also reported at this short review. Four local families studied with various markers at the chromosome 21, 19, 14, and 1 are briefly reported for the first time. The importance of studying DNA samples from Brazil is highlighted because of the uniqueness of its population, which presents both intense ethnical miscegenation, mainly at the east coast, but also clusters with high inbreeding rates in rural areas at the countryside. We discuss the current stage of extending these studies using high-throughput methods of large-scale genotyping, such as single nucleotide polymorphism microarrays, associated with bioinformatics tools that allow the analysis of such extensive number of genetics variables, with different levels of penetrance. There is still a long way between the huge amount of data gathered so far and the actual application toward the full understanding of AD, but the final goal is to develop precise tools for diagnosis and prognosis, creating new strategies for better treatments based on genetic profile.

A prática da educação física : problemas e alternativas transformadoras na ação educativa e social

O presente trabalho teve por objetivo traçar um quadro das dificuldades enfrentadas pelos professores que lidam com a Educação Física nas escolas de 1º, 2º e 3º graus de Porto Alegre e apresentar alternativas práticas para a superação destas dificuldades. Fizeram parte do estudo professores de Educação Física de 74 escolas estaduais, particulares e municipais de 1º e 2º graus e, professores de 6 estabelecimentos particulares e federais de ensino superior de Porto Alegre, num total de 275 indivíduos. A coleta de dados realizou-se através de questionário aberto, escala de opinião tipo Likert, observação de aulas e análise de documentos legais. Para a interpretação estatística utilizou-se os testes t análise de variância e teste U de Mann-Whitney. Para as informações de natureza qualitativa utilizou-se a técnica da Análise de Conteúdo. Os resultados obtidos indicaram que em relação à formação profissional recebida no curso de Educação Física atender às exigências da realidade de trabalho, não houve diferença significativa entre os professores das escolas particulares e públicas de 1º e 2º grau. Os professores, de forma geral, consideraram a área biológica como a mais adequada, seguida das áreas técnico-profissional e didático-pedagógica. A área humanística foi considerada a menos adequada. Em relação aos aspectos estruturais houve diferença significativa entre as respostas dos professores das escolas particulares e públicas de 1º e 2º graus. Os professores das escolas particulares consideram suas condições mais adequadas que os professores das escolas públicas. No ensino superior a situação se inverteu, os professores das escolas públicas consideraram suas condições melhores do que os das escolas particulares. Em relação ao local de trabalho constatou-se diferença significativa entre as escolas públicas e particulares de 1º e 2º grau. Os professores das escolas particulares consideram as condições de seu local de trabalho mais adequadas. Quanto aos aspectos didáticos-pedagógicos, tanto os professores das escolas públicas como das particulares de 1º e 2º graus consideraram que seus alunos mostram-se comprometidos com as aulas de Educação Física. Esses resultados formaram um quadro bastante coerente quando confrontados com a política econômica adotada pelo governo nas últimas décadas que repercutiu na educação sobre a forma de privatização e de utilização do ensino superior como instrumento de formação de mão-de-obra para o desenvolvimento do país nos moldes capitalistas. Como alternativas para a superação dessas dificuldades recomendamos: - a nível de formação profissional: o acréscimo de disciplinas da área humanística que permitam a aquisição de conhecimentos mais aprofundados sobre as questões políticas e sociais do professor de Educação Física; - a nível de local de trabalho: a integração dos conteúdos das aulas de Educação Física aos conteúdos das outras disciplinas curriculares principalmente nas primeiras séries do 1º grau; - em relação aos aspectos didático-pedagógicos: fornecer conhecimentos teóricos sobre a Educação Física que permitam aos alunos desenvolver atividades físicas e desportivas, mesmo fora da escola, de forma consciente e independente, com condições de identificar seus benefícios e malefícios sem auxílio do professor; - a nível estrutural recomendamos a militância em espaços que permitam uma interferência mais direta nas questões políticas e econômicas do país, tais como: associações, sindicatos e partidos políticos.

First Description of a Cluster of Acute/Subacute Paracoccidioidomycosis Cases and Its Association with a Climatic Anomaly

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Medical students' personal choice for mode of delivery in Santa Catarina, Brazil: a cross-sectional, quantitative study

Background: The increase in overall rates of cesarean sections (CS) in Brazil causes concern and it appears that multiple factors are involved in this fact. In 2009, undergraduate students in the first and final years of medical school at the University of Santa Catarina answered questionnaires regarding their choice of mode of delivery. The aim of the study was to evaluate whether the education process affects decision-making regarding the waay of childbirth preferred by medical students.Methods: A cross-sectional, quantitative study was conducted based on data obtained from questionnaires applied to medical students. The questions addressed four different scenarios in childbirth, as follows: under an uneventful pregnancy; the mode of delivery for a pregnant woman under their care; the best choice as a healthcare manager and lastly, choosing the birth of their own child. For each circumstance, there was an open question to explain their choice.Results: A total of 189 students answered the questionnaires. For any uneventful pregnancy and for a pregnant woman under their care, 8.46% of the students would opt for CS. As a healthcare manager, only 2.64% of the students would recommend CS. For these three scenarios, the answers of the students in the first year did not differ from those given by students in the sixth year. In the case of the student's own or a partner's pregnancy, 41.4% of those in the sixth year and 16.8% of those in the first year would choose a CS. A positive association was found between being a sixth year student and a personal preference for CS according to logistic regression (OR = 2.91; 95%CI: 1.03-8.30). Pain associated with vaginal delivery was usually the reason for choosing a CS.Conclusions: A higher number of sixth year students preferred a CS for their own pregnancy (or their partner's) compared to first year students. Pain associated with vaginal delivery was the most common reason given for haven chosen a CS. The students' preference for childbirth changed over time during their graduation in favor of cesarean sections. This finding deserves considerable attention when structuring medical education in Obstetrics.

Growth and developmental outcomes of the extremely preterm infant

Objetive: To provide information for pediatricians and neonatologists to create realistic outcome expectations and thus help plan their actions. Sources of data: Searches were made of the Cochrane Library, MEDLINE, and Lilacs databases. Summary of the findings: The assessment of growth and development over the first 2-3 years must adjust chronological age with respect of the degree of prematurity. There is special concern regarding the prognoses of small for gestational age preterm infants, and for those with bronchopulmonary dysplasia. Attention must be directed towards improving the nutrition of extremely low birth weight infants during their first years of life; these infants have high prevalence levels of failure to catch-up on growth, diseases and rehospitalizations during their first 2 years. They are frequently underweight and shorter than expected during early childhood, but delayed catch-up growth may occur between 8 and 14 years. Extremely low birth weight infants are at increased risk of neurological abnormalities and developmental delays during their first years of life. Educational, psychological, and behavioral problems are frequent during school years. Teenage and adult outcomes show that although some performance differences persist, social integration is not impaired. Conclusions: The growth and neurodevelopment of all ELBW infants must be carefully monitored after discharge, to ensure that children and their families receive adequate support and intervention to optimize prognoses. Copyright © 2005 by Sociedade Brasileira de Pediatria.

Ten years of NO2 comparisons between ground-based SAOZ and satellite instruments (GOME, SCIAMACHY, OMI)

SAOZ (Systeme d'Analyse par Observations Zenithales) is a ground-based UV-Visible zenith-sky spectrometer installed between 1988 and 1995 at a number of NDSC stations at various latitudes on the globe. The instrument is providing ozone and NO2 vertical columns at sunrise and sunset using the Differential Optical Absorption Spectroscopy (DOAS) technique in the visible spectral range. The ERS-2 GOME Ozone Monitoring Experiment (GOME) in 1995 was the first satellite mission to provide a global picture of atmospheric NO 2 with reasonable spatial and temporal resolution. It was then followed by SCanning ImAging spectroMeter for Atmospheric ChartographY (SCIAMACHY) onboard ENVISAT in 2002, and Ozone Monitoring Instrument (OMI) onboard EOS-AURA in 2004, with a similar capacity to monitor total NO 2. All these instruments are nadir viewing mapping spectrometers, applying the DOAS technique in the visible for deriving the NO2 total column. Here we present the results of NO2 long-term comparisons between GOME and SAOZ for the whole period of GOME operation since 1995 at all latitudes - tropics, mid-latitudes and polar regions - in both hemispheres. Comparisons are also shown with the most recently available SCIAMACHY and OMI data in 2004-2005. Overall, the daytime satellite measurements (around noon) are found consistent with sunrise ground-based data, with an average smaller difference at the tropics and mid-latitudes than in the polar areas in the summer. The agreement is even improved after correcting for the NO2 photochemical change between sunrise and the satellite overpass using a box model. However, some seasonal dependence of the difference between ground-based and satellite total NO2 still remains, related to the accuracy of photochemical simulations and the set of NO2 air mass factors used in the retrievals of both systems.

Bioethanol - Brazil, 30 years of Proálcool

Brazil, which has always been in the forefront of sugarcane production, also occupies a prominent position as the first country to produce and use biofuel in its automobile fleet. This fact is a consequence of the introduction of a program which has already turned 30 years, the Próalcool (National Alcohol Program). The oil crisis in the seventies encouraged the government to develop an alternative way to replace gasoline. Bioethanol was then born as fuel obtained from fermentation of sugarcane juice, molasses or both. In the eighties, 85% of the cars ran exclusively on alcohol. Ethanol production in that decade exceeded sugarcane production by the mills. The installed units reached in that period the capacity to produce 18 billion liters of bioethanol per season, a volume equivalent to 100 million barrels of gasoline. The fermentation process, which so far had been restricted to manufacturing sugarcane liquor (aguardente) or ethanol as a byproduct of sugarcane, takes over the spotlight in the entrepreneurial scene. As a result, processes comprising engineering concepts came up and most of the biological phenomena involved in fermentation were understood. The knowledge gathered and the units installed have granted Brazil the hold of production technology and use of a clean fuel.

Seven years of external control of fluoride levels in the public water supply in Bauru, São Paulo, Brazil

luoridation of the public water supplies is recognized as among the top ten public health achievements of the twentieth century. However, the positive aspects of this measure depend on the maintenance of fluoride concentrations within adequate levels. Objective: To report the results of seven years of external control of the fluoride (F) concentrations in the public water supply in Bauru, SP, Brazil in an attempt to verify, on the basis of risk/ benefit balance, whether the levels are appropriate. Material and Methods: From March 2004 to February 2011, 60 samples were collected every month from the 19 supply sectors of the city, totaling 4,641 samples. F concentrations in water samples were determined in duplicate, using an ion-speciflc electrode (Orion 9609) coupled to a potentiometer after buffering with TISAB II. After the analysis, the samples were classified according to the best risk-benefit adjustment. Results: Means (±standard deviation) of F concentrations ranged between 0.73±0.06 and 0.81±0.10 mg/L for the different sectors during the seven years. The individual values ranged between 0.03 and 2.63 mg/L. The percentages of the samples considered low risk for dental fluorosis development and of maximum benefit for dental caries prevention (0.55-0.84 mg F/L) in the first, second, third, fourth, fifth, sixth, and seventh years of the study were 82.0, 58.5, 37.4, 61.0, 89.9, 77.3, and 72.4%, respectively, and 69.0% for the entire period. Conclusions: Fluctuations of F levels were found in the public water supply in Bauru during the seven years of evaluation. These results suggest that external monitoring of water fluoridation by an independent assessor should be implemented in cities where there is adjusted fluoridation. This measure should be continued in order to verify that fluoride levels are suitable and, if not, to provide support for the appropriate adjustments.

Construction and validation of an instrument to assess the reading comprehension of students from the third to the fifth grades of elementary school

Objetivo:Este estudo teve como objetivo construir e validar um instrumento de avaliação da compreensão de leitura a fim de caracterizar o perfil de leitura e detectar dificuldades de compreensão em escolares do terceiro ao quinto ano do Ensino Fundamental.Métodos:Participaram 378 escolares divididos em trés grupos para avaliação da compreensão de proposições literais e inferenciais de micro e macroestruturas de dois textos expositivos e dois textos narrativos por meio de questões de múltipla escolha.Resultados:Os dados analisados estatisticamente indicaram valores do teste alfa de Cronbach apresentando consisténcia interna nos quatros textos aplicados para os trés grupos.Conclusão:Foi possível constatar que os escolares apresentaram menor número de erros com o aumento da escolarização e que cada tipo de texto apresentou uma dificuldade específica para os escolares.

Soil microbial biomass after two years of the consecutive application of composted tannery sludge

Because the agricultural use of tannery sludge may cause increased risks to soils, composting is recognized as one of the most suitable alternative for tannery sludge recycling. Experiments were conducted under field conditions to evaluate the effects of composted tannery sludge (CTS) on the soil microbial biomass and trace elements after two years of consecutive applications. The following five treatments were used: 0 (without CTS application), 5, 10, 20 and 40 ton ha-1 of CTS (dry basis). Soil samples were collected at 60 days after the CTS application at 0-20 cm depth. The CTS application promoted changes in the soil microbial biomass C (SMB-C) and N (SMB-N). In the first year, significant increases in the SMB-C and SMB-N were observed with the application of 10 ton ha-1. Furthermore, CTS application increased the Cr content in the soil after two years of application.

Segmentações não-convencionais de palavra nos quatro últimos anos do ensino fundamental: um estudo longitudinal

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A arte do teatro na educação durante a infância: a percepção dos professores acerca de suas contribuições

Seeking new ways to be used in the process of teaching and learning, he turned a look at alternative lines of research, going to value the arts in education, and inside, there has been a major focus of the relationship to both the theater and education. Currently, the theater has been the subject of research in education and has been also widely used as an educational resource, and its adoption by professionals is based on studies showing the contributions of the theater to child development. The theater, while playing, artistic expression and involves imagination, creation and sociability.This paper presents child development in all its phases, the importance of games, especially the symbolic games, during this process, through the perspective of Jean Piaget, a brief history of the theater within the education and the contributions actuallyits use as methodology of teaching and learning brings to children's development of the early years of elementary school, bringing the discussion as teachers' perception about the real possibility of its use in schools as a way of teaching and learning. This research aimed to understand the dialogic relationship between theater and basic education, emphasizing its most striking features, emphasize its presence in the teaching and learning in basic education, focusing on the early years of primary education; see how the skills developed with drama can help develop cognitive, psychological, social and moral development of children, performing an initial survey on the possibilities of using the theater within the lesson plans for teachers in the first grade of elementary school and learn the opinions of professional education on theresearch subject, being held with four teachers who teach in the first years of elementary education at a public school in Santa Cruz do Rio Pardo, ...(Complete abstract click electronic address below)

A cultura escrita nos anos iniciais do ensino fundamental: implicações pedagógicas da Teoria Histórico- Cultural

Pós-graduação em Educação - FFC