Collagen XII: Protecting bone and muscle integrity by organizing collagen fibrils.

Collagen XII, largest member of the fibril-associated collagens with interrupted triple helix (FACIT) family, assembles from three identical α-chains encoded by the COL12A1 gene. The molecule consists of three threadlike N-terminal noncollagenous NC3 domains, joined by disulfide bonds and a short interrupted collagen triple helix toward the C-terminus. Splice variants differ considerably in size and properties: "small" collagen XIIB (220 kDa subunit) is similar to collagen XIV, whereas collagen XIIA (350 kDa) has a much larger NC3 domain carrying glycosaminoglycan chains. Collagen XII binds to collagen I-containing fibrils via its collagenous domain, whereas its large noncollagenous arms interact with other matrix proteins such as tenascin-X. In dense connective tissues and bone, collagen XII is thought to regulate organization and mechanical properties of collagen fibril bundles. Accordingly, recent findings show that collagen XII mutations cause Ehlers-Danlos/myopathy overlap syndrome associated with skeletal abnormalities and muscle weakness in mice and humans.

De Ivdaeorvm Tolerantia Legvm Series Temporvm Ordine Digesta Ac Speciatim Moeno-Francofvrtensi : Ad Reformat. P. II, Tit. XII

Tübingen, Univ., Diss. 1772

De Ivdaeo Creditore Tam Ex Ivre Commvni Qvam Patrio Occasione Reform. Francof. Part. II. Tit. XII : Dissertatio Inavgvralis Ivridica

Altdorf, Univ., Diss., 1733

Geschichte der Juden in England im XI. und XII. Jahrhundert

Berlin, Univ., Diss., 1886

Forderungen an den XII. Zionistenkongress : Grundlinien e. Aktionsprogramms

von Jakob Klatzkin

Reisetagebuch des Rabbin Binjamin von Tudela : ein Beitrag zur Kenntniß der Juden in der Diaspora während des XII. Jahrhunderts

Binjamin ben-Jona aus Tudela. [Übers.: A. Martinet]

Joseph Bechor Schor, ein nordfranzösischer Bibelerklärer des XII. Jahrhunderts

von N. Porges

Ms. Carm. 6 - Sophologium. Quodlibeta XII

Vorbesitzer: Johannes Münzenberger (F I M); Karmeliterkloster Frankfurt am Main

Ms. Barth. 77 - De laudibus beatae Mariae virginis libri XII

Vorbesitzer: Dominikanerkloster Frankfurt am Main; Bartholomaeusstift Frankfurt am Main

Jüdische Hochzeitsbräuche in alter und neuer Zeit : (Fortsetzung aus Heft XII)

Bar-Ami