990 resultados para Walker, Marquise


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Printed by the Plimpton Press, Norwood, Mass.

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At head of title: Circuit court of the United States, district of Vermont. In equity.

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Mode of access: Internet.

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"Ouvrage reconnu apocryphe, et dont l'auteur est un prétendu comte de Courchamps, dont le nom véritable est Causen (de Saint-Malo)" Nouv. biog. gén., t. 12; Encycl. brit., 11th ed., vol. VII, p. 411, and Quérard, Superchéries litt., v. 1, p. 290, give the form Cousin.

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BACKGROUND: Patients with advanced cancer suffer from cachexia, which is characterised by a marked weight loss, and is invariably associated with the presence of tumoral and humoral factors which are mainly responsible for the depletion of fat stores and muscular tissue. METHODS: In this work, we used cytotoxicity and enzymatic assays and morphological analysis to examine the effects of a proteolysis-inducing factor (PIF)-like molecule purified from ascitic fluid of Walker tumour-bearing rats (WF), which has been suggested to be responsible for muscle atrophy, on cultured C2C12 muscle cells. RESULTS: WF decreased the viability of C2C12 myotubes, especially at concentrations of 20-25 mug.mL-1. There was an increase in the content of the pro-oxidant malondialdehyde, and a decrease in antioxidant enzyme activity. Myotubes protein synthesis decreased and protein degradation increased together with an enhanced in the chymotrypsin-like enzyme activity, a measure of functional proteasome activity, after treatment with WF. Morphological alterations such as cell retraction and the presence of numerous cells in suspension were observed, particularly at high WF concentrations. CONCLUSION: These results indicate that WF has similar effects to those of proteolysis-inducing factor, but is less potent than the latter. Further studies are required to determine the precise role of WF in this experimental model. © 2008 Yano et al; licensee BioMed Central Ltd.

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Case law report - online

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Book review: Oxford: Oxford University Press, 2011, lxxiii + 538 + (index) 15pp (£145.00 hardback). ISBN: 978-0-19-956117-9.

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General note: Title and date provided by Bettye Lane.

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