925 resultados para Transmitter attachment
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"31 January 1983."
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"30 December 1965."
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Includes index.
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Includes indexes.
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"28 July 1965."
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"May 1976."
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"5 July 1983."
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"5 July 1983."
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"5 January 1982."
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Includes index.
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Keith Bemand, Elton Plank, Mr. Trumbull
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C.C. Bradner, Walter Hoffman, Wynn Wright, Ty Tyson, Harry Bannister, Herschel Hart, Jeff B. Webb, William Scripps, William E. Scripps, Warren S. Booth, Herb Ponting.
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Mode of access: Internet.
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Thesis (Master's)--University of Washington, 2016-06
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We expressed the full-length CD44v2-10 isoform in SKHep1 cells, a nonmetastatic human hepatocellular carcinoma cell line that does not express any endogenous CD44v isoforms. In SCID mice, expression of CD44v2-10 by SKHep1 cells had no effect on s.c. primary tumor development but caused pulmonary metastases in 41% (7 of 17) of animals compared with control SKHep1 cells (0 of 16; P < 0.01). CD44v2-10 expression by SKHep1 cells resulted in enhanced heparan sulfate (HS) attachment and an enhanced capacity to bind heparin-binding growth factors. Mutation of the v3 domain to prevent HS attachment and growth factor binding abolished the metastatic phenotype, demonstrating that HS modification of CD44v2-10 plays a critical role in the development of metastases in this model. However, in vitro proliferation, motility, and invasion were not altered by CD44v2-10 expression.