Russia's policy in the Southern Caucasus and Central Asia. OSW Study 23/2006

The Southern Caucasus and Central Asia are priority areas for the foreign policy of the Russian Federation. Russia mainly sees its influence in both regions as an important factor determining its international stature, and as a precondition for reinforcing its position as a world power. The Caucasus and Central Asia are also important for Russia from the points of view of economy, especially because of those area's natural resource wealth, and security, as both regions generate serious potential threats to the Russian Federation, including Islamic fundamentalism, terrorism, the drugs trade and illegal migration.

Frequency of MELAS main mutation in a phenotype-targeted young ischemic stroke patient population

Mitochondrial diseases, predominantly mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), may occasionally underlie or coincide with ischemic stroke (IS) in young and middle-aged individuals. We searched for undiagnosed patients with MELAS in a target subpopulation of unselected young IS patients enrolled in the Stroke in Young Fabry Patients study (sifap1). Among the 3291 IS patients aged 18-55 years recruited to the sifap1 study at 47 centers across 14 European countries, we identified potential MELAS patients with the following phenotypic features: (a) diagnosed cardiomyopathy or (b) presence of two of the three following findings: migraine, short stature (≤165 cm for males; ≤155 cm for females), and diabetes. Identified patients' blood samples underwent analysis of the common MELAS mutation, m.3243A>G in the MTTL1 gene of mitochondrial DNA. Clinical and cerebral MRI features of the mutation carriers were reviewed. We analyzed blood samples of 238 patients (177 with cardiomyopathy) leading to identification of four previously unrecognized MELAS main mutation carrier-patients. Their clinical and MRI characteristics were within the expectation for common IS patients except for severe hearing loss in one patient and hyperintensity of the pulvinar thalami on T1-weighted MRI in another one. Genetic testing for the m.3243A>G MELAS mutation in young patients with IS based on phenotypes suggestive of mitochondrial disease identifies previously unrecognized carriers of MELAS main mutation, but does not prove MELAS as the putative cause.

Accident and near accident causation: the contribution of automobile design characteristics. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Sexual dimorphism of the femoral neck during the adolescent growth spurt: a structural analysis

Before puberty, there are only small sex differences in body shape and composition. During adolescence, sexual dimorphism in bone, lean, and fat mass increases, giving rise to the greater size and strength of the male skeleton. The question remains as to whether there are sex differences in bone strength or simply differences in anthropometric dimensions. To test this, we applied hip structural analysis (HSA) to derive strength and geometric indices of the femoral neck using bone densitometry scans (DXA) from a 6-year longitudinal study in Canadian children. Seventy boys and sixty-eight girls were assessed annually for 6 consecutive years. At the femoral neck, cross-sectional area (CSA, an index of axial strength), subperiosteal width (SPW), and section modulus (Z, an index of bending strength) were determined, and data were analyzed using a hierarchical (random effects) modeling approach. Biological age (BA) was defined as years from age at peak height velocity (PHV). When BA, stature, and total-body lean mass (TB lean) were controlled, boys had significantly higher Z than girls at all maturity levels (P < 0.05). Controlling height and TB lean for CSA demonstrated a significant independent sex by BA interaction effect (P < 0.05). That is, CSA was greater in boys before PHV but higher in girls after PHV The coefficients contributing the greatest proportion to the prediction of CSA, SPW, and Z were height and lean mass. Because the significant sex difference in Z was relatively small and close to the error of measurement, we questioned its biological significance. The sex difference in bending strength was therefore explained by anthropometric differences. In contrast to recent hypotheses, we conclude that the CSA-lean ratio does not imply altered mechanosensitivity in girls because bending dominates loading at the neck, and the Z-lean ratio remained similar between the sexes throughout adolescence. That is, despite the greater CSA in girls, the bone is strategically placed to resist bending; hence, the bones of girls and boys adapt to mechanical challenges in a similar way. (C) 2004 Elsevier Inc. All rights reserved.

Expression of SHOX in human fetal and childhood growth plate

Abnormalities in the growth plate may lead to short stature and skeletal deformity including Leri Weil syndrome, which has been shown to result from deletions or mutations in the SHOX gene, a homeobox gene located at the pseudoautosomal region of the X and Y chromosome. We studied the expression of SHOX protein, by immunohistochemistry, in human fetal and childhood growth plates and mRNA by in situ hybridization in childhood normal and Leri Weil growth plate. SHOX protein was found in reserve, proliferative, and hypertrophic zones of fetal growth plate from 12 wk to term and childhood control and Leri Weil growth plates. The pattern of immunostaining in the proliferative zone of childhood growth plate was patchy, with more intense uniform immunostaining in the hypertrophic zone. In situ hybridization studies of childhood growth plate demonstrated SHOX mRNA expression throughout the growth plate. No difference in the pattern of SHOX protein or mRNA expression was seen between the control and Leri Weil growth plate. These findings suggest that SHOX plays a role in chondrocyte function in the growth plate.

Peter Brown's The 'rise of western christendom', second edition: A review essay

Peter Brown, perhaps the world's leading scholar in the field of late antiquity, has produced a substantially revised and expanded edition of one of his major books, drawing on the vast volume of recent work. This essay summarizes its central arguments, especially the significance it attributes to developments away from the Mediterranean and to the seventh century, which together allow the topic to be seen in a compelling new light. It applauds the sustained excellence of Brown's prose, as well as his frame of reference and historical imagination. Some questions are raised concerning his deployment of sources, the importance given to the north, the ability to make decisions that people are credited with, and the coming of Islam. That a scholar of Brown's eminence is able to relish and appropriate effectively work that appeared subsequent to the first edition of this book is a tribute to his stature.

Heterozygote effects in mice with partial truncations in the growth hormone receptor cytoplasmic domain: Assessment of growth parameters and phenotype

The GH receptor (GHR) is essential for normal postnatal growth and development, and the molecular basis of GHR action has been studied intensively. Clinical case studies and more recently mouse models have revealed the extensive phenotype of impaired GH action. We recently reported two new mouse models, possessing cytoplasmic truncations at position 569 (plus Y539/545-F) and 391, which were created to identify functional subdomains within the cytoplasmic signaling domain. In the homozygous state, these animals show progressively impaired postnatal growth coupled with complex changes in gene expression. We describe here an extended phenotype analysis encompassing the heterozygote state to identify whether single copies of these mutant receptors bring about partial or dominant-negative phenotypes. It appears that the retention of the ubiquitin-dependent endocytosis motif the N-terminal cytoplasmic domain permits turnover of these mutant receptors because no dominant-negative phenotype is seen. Nonetheless, we do observe partial impairment of postnatal growth in heterozygotes supporting limited haploinsufficiency. Reproductive function is impaired in these models in a progressive manner, in parallel with loss of signal transducer and activator of transcription-5 activation ability. In summary, we describe a more comprehensive phenotypic analysis of these mouse models, encompassing overall and longitudinal body growth, reproductive function, and hormonal status in both the heterozygote and homozygote state. Our results suggest that patients expressing single copies of similarly mutated GHRs would not display an obvious clinical phenotype.

Variation in mangrove forest structure and sediment characteristics in Bocas del Toro, Panama

Mangrove forest structure and sediment characteristics were examined in the extensive mangroves of Bocas del Toro, Republic of Panama. Forest structure was characterized to determine if spatial vegetation patterns were repeated over the Bocas del Toro landscape. Using a series of permanent plots and transects we found that the forests of Bocas del Toro were dominated by Rhizophora maugle with very few individuals of Avicennia germinans and Laguncularia racemosa. Despite this low species diversity, there was large variation in forest structure and in edaphic conditions (salinity, concentration of available phosphorus, Eh and sulphide concentration). Aboveground biomass varied 20-fold, from 6.8 Mg ha(-1) in dwarf forests to 194.3 Mg ha(-1) in the forests fringing the land. But variation in forest structure was predictable across the intertidal zone. There was a strong tree height gradient from seaward fringe (mean tree height 3.9 m), decreasing in stature in the interior dwarf forests (mean tree height 0.7 m), and increasing in stature in forests adjacent to the terrestrial forest (mean tree height 4.1 m). The predictable variation in forest structure emerges due to the complex interactions among edaphic and plant factors. Identifying predictable patterns in forest structure will aid in scaling up the ecosystem services provided by mangrove forests in coastal landscapes.

Prediction of height from knee height in children with cerebral palsy and non-disabled children

Measurement of height or length is essential in the assessment of nutritional status. In some conditions, for example cerebral palsy (CP), such measurements may be difficult or impossible. Proxy measurements such as knee height have been used to predict height in such cases. We have evaluated two equations in the literature that predict stature from knee height in a group of 17 children with CP and 20 non-disabled children. The two equations performed well on average in the non-disabled children, with the mean predicted height being within 1% of the mean measured height. Nevertheless, the limits of agreement were relatively large. This was also the case for the children with CP. Thus the equations may be accurate at the group level; however they may lead to unacceptable error at the individual level. © 2006 Informa UK Ltd.

Bias, precision and heritability of self-reported and clinically measured height in Australian twins

Many studies of quantitative and disease traits in human genetics rely upon self-reported measures. Such measures are based on questionnaires or interviews and are often cheaper and more readily available than alternatives. However, the precision and potential bias cannot usually be assessed. Here we report a detailed quantitative genetic analysis of stature. We characterise the degree of measurement error by utilising a large sample of Australian twin pairs (857 MZ, 815 DZ) with both clinical and self-reported measures of height. Self-report height measurements are shown to be more variable than clinical measures. This has led to lowered estimates of heritability in many previous studies of stature. In our twin sample the heritability estimate for clinical height exceeded 90%. Repeated measures analysis shows that 2-3 times as many self-report measures are required to recover heritability estimates similar to those obtained from clinical measures. Bivariate genetic repeated measures analysis of self-report and clinical height measures showed an additive genetic correlation > 0.98. We show that the accuracy of self-report height is upwardly biased in older individuals and in individuals of short stature. By comparing clinical and self-report measures we also showed that there was a genetic component to females systematically reporting their height incorrectly; this phenomenon appeared to not be present in males. The results from the measurement error analysis were subsequently used to assess the effects of error on the power to detect linkage in a genome scan. Moderate reduction in error (through the use of accurate clinical or multiple self-report measures) increased the effective sample size by 22%; elimination of measurement error led to increases in effective sample size of 41%.

Associação do sobrepeso, obesidade I e II e circunferência da cintura com sintomas de ansiedade e depressão

Este estudo objetivou associar o sobrepeso, obesidade I e II e Circunferência da Cintura (CC) com sintomas de ansiedade e depressão em adultos que buscavam primeiro atendimento médico nutricional para emagrecimento em consultório do município de Santos São Paulo - Brasil, mesmo os que já haviam tentado emagrecer anteriormente. Para coletar dados, foi utilizada uma ficha para caracterização do participante, Inventário IDATE para ansiedade traço estado, Inventário de Beck (BDI) para depressão, balança antropométrica para aferição do peso, altura e cálculo do Índice de Massa Corporal (IMC), fita métrica inelástica para aferir CC. Os dados dos 81 participantes demonstraram que 38% eram jovens, 36% casados, 63% possuíam nível superior completo, 45% alta renda familiar. Estavam em sobrepeso 56% e obesidade I 28%, e 64% apresentavam 77 a 100 cm de CC. A análise simples da distribuição dos sintomas de ansiedade e depressão na elevação do IMC e da CC demonstra que, conforme estes aumentam, a ansiedade e depressão diminuem. Houve alta ocorrência de sintomas de ansiedade traço (75%) estado (70%) de intensidade média baixa e de depressão mínima (64%) que decaem de freqüência conforme eleva o IMC e a CC, bem como redução de freqüência às consultas conforme eleva o IMC. Não houve casos de depressão grave. A análise estatística de Pearson não encontrou correlação entre IMC e CC com sintomas de ansiedade e depressão, o mesmo ocorrendo com o teste para associação Qui-quadrado. Os resultados sugerem ocorrer uma acomodação emocional do indivíduo às pressões causadas pela elevação do peso corporal e os participantes apresentavam-se, em sua maioria, hiporreativos, indiferentes ou insensíveis aos acontecimentos, com desinteresse geral ou falta de desejos aparentando resistência ao tratamento e apatia.

Cause, effect and benefits of a standardised corporate visual identity system of UK companies operating in Malaysia

Investigates the degree of global standardisation of a corporate visual identity system (CVIS) in multinational operations. A special emphasis of this research is accorded to UK companies operating in Malaysia. In particular, the study seeks to reveal the reasons for developing a standardised CVIS; the behavioural issues associated with CVIS; and the determination in selecting a graphic design agency. The findings of the research revealed that multinational corporations in an increasingly corporate environment adopted a standardised CVIS for several reasons, including, aiding the sale of products and services, creating an attractive environment for hiring employees, and increasing the company’s stature and presence. Further findings show that the interest in global identity was stimulated by global restructuring, merger or acquisition. The above trends help explain why increased focus has been accorded to CVIS over the past five years by many UK companies operating in Malaysia. Additional findings reveal that both the UK design agencies and in-house design department are used in the development of the firms’ CVIS.

Advancing theory and research and the British journal of management

In an ecosystem of management journals dominated by US heavyweights, the British Journal of Management (BJM) assumes a unique role. There is no other European business and management journal of the standing and stature of this journal that seeks both to be multidisciplinary and to appeal to a general readership of business and management scholars. This is a tribute to the efforts of previous editorial teams. At the same time, the journal faces the challenge of remaining relevant both to the immediate British Academy of Management community and to the wider scholarly one, while raising its own game in pioneering and leading debates, and in global esteem. © 2014 British Academy of Management.

Le groupe du Fer de Lance mélanésien face à ses défis

Cet article examine la complexité du processus d’intégration régionale en Océanie à travers le cas du groupe du Fer de Lance mélanésien (gflm). L’émergence de cette structure subrégionale en 1988 avait pour but d’affirmer la spécificité mélanésienne au cœur du Pacifique Sud. Or, en vingt-cinq années d’existence, le Fer de Lance ne semble pas avoir pleinement réalisé tous les objectifs qu’il s’était initialement fixés. Ses ambitions, politiques en particulier, ne sont qu’en partie réalisées. Quant à la récente présidence fidjienne du Fer de Lance, elle a tenté de donner une nouvelle stature régionale au groupe, mais y est-elle parvenue ? Cet article analyse les défis politiques, intérieurs et extérieurs, que le gflm rencontre depuis sa création et considère ceux qui lui restent à relever. This paper examines the complexities of regional integration in Oceania through the case study of the Melanesian Spearhead Group (MSG). The emergence of a new subregional structure in 1988 aimed to support the development of the Melanesian identity within the South Pacific. However, after twenty-five years of existence, the Spearhead Group does not seem to have reached all its initial objectives. Its political ambition has only partly been achieved. The recent Fijian leadership of the MSG has attempted to give a new regional dimension to the Melanesian group, but has it succeeded? This paper analyses how the subregional group has faced the challenges that emerged from its regional environment as well as from within its own structure. It fnally considers the new challenges ahead for the Melanesian group.

Technological challenges of pediatric MEG and potential solutions:the Aston experience

Magnetoencephalography (MEG) offers significant opportunities for the localization and characterization of focal and generalized epilepsies, but its potential has so far not been fully exploited, as the evidence for its effectiveness is still anecdotal. This is particularly true for pediatric epilepsy. MEG recordings on school-age children typically rely on the use of MEG systems that were designed for adults and children's smaller head-size and stature can cause significant problems. Reduced signal-to-noise ratio when recording from smaller heads, increased movement, reduced sensor coverage of anterior temporal regions and incomplete insertion into the MEG helmet can all reduce the quality of data collected from children. We summarize these challenges and suggest some practical solutions.