Genomic analysis of the blood attributed to Louis XVI (1754-1793), king of France.

A pyrographically decorated gourd, dated to the French Revolution period, has been alleged to contain a handkerchief dipped into the blood of the French king Louis XVI (1754-1793) after his beheading but recent analyses of living males from two Bourbon branches cast doubts on its authenticity. We sequenced the complete genome of the DNA contained in the gourd at low coverage (similar to 2.5x) with coding sequences enriched at a higher similar to 7.3x coverage. We found that the ancestry of the gourd's genome does not seem compatible with Louis XVI's known ancestry. From a functional perspective, we did not find an excess of alleles contributing to height despite being described as the tallest person in Court. In addition, the eye colour prediction supported brown eyes, while Louis XVI had blue eyes. This is the first draft genome generated from a person who lived in a recent historical period; however, our results suggest that this sample may not correspond to the alleged king.

The history of Lapland : containing a geographical description, and a natural history of that country; with an account of the inhabitants, their original, religion, customs, habits, marriages, conjurations, employments, &c. Written by John Scheffer, ... Translated from the last edition in Latin, and illustrated with many curious copper-cutts. To which are added, the travels of the King of Sweden's mathematicians into Lapland: the history of Livonia, and the wars there: also a journey into Lapland, Finland, &c. Written by Dr. Olof Rudbeck in the year 1701

Added engraved title page: The history of Lapland.

The expedition of Alexander the Great, first king of Persia : according to Quintus Curtius, Arrian, and others

Julkaisussa: Geographia classica : the geography of the ancients

The brain decade in debate: III. Neurobiology of emotion

This article is a transcription of an electronic symposium in which active researchers were invited by the Brazilian Society of Neuroscience and Behavior (SBNeC) to discuss the advances of the last decade in the neurobiology of emotion. Four basic questions were debated: 1) What are the most critical issues/questions in the neurobiology of emotion? 2) What do we know for certain about brain processes involved in emotion and what is controversial? 3) What kinds of research are needed to resolve these controversial issues? 4) What is the relationship between learning, memory and emotion? The focus was on the existence of different neural systems for different emotions and the nature of the neural coding for the emotional states. Is emotion the result of the interaction of different brain regions such as the amygdala, the nucleus accumbens, or the periaqueductal gray matter or is it an emergent property of the whole brain neural network? The relationship between unlearned and learned emotions was also discussed. Are the circuits of the former the underpinnings of the latter? It was pointed out that much of what we know about emotions refers to aversively motivated behaviors, like fear and anxiety. Appetitive emotions should attract much interest in the future. The learning and memory relationship with emotions was also discussed in terms of conditioned and unconditioned stimuli, innate and learned fear, contextual cues inducing emotional states, implicit memory and the property of using this term for animal memories. In a general way it could be said that learning modifies the neural circuits through which emotional responses are expressed.

History of England from the peace of Utrecht to the peace of Aix-la-Chapelle. Edition 3,Volume 2 / by lord Mahon

Collection : Collection of ancient and modern british authors ; 325-326

History of England from the peace of Utrecht to the peace of Aix-la-Chapelle. Volume 1,Edition 3 / by lord Mahon

Collection : Collection of ancient and modern british authors ; 325-326

Recueil de traités entre la France et l'Angleterre ; histoire d'Edouard IV et de Richard III, par Thomas Morus.

Contient : 1 Ordonnance faite par CHARLES [V], « aisné filz du roy de France et son lieutenant », en conformité des conseils donnés par l'assemblée des trois états du royaume, pour la suppression de divers abus et l'établissement de plusieurs réglements. Paris, mars 1356 ; 2 Traité de Brétigny, entre le roi de France et le roi d'Angleterre. 8 mai 1460 ; 3 Traité entre François Ier et Henri VIII, roi d'Angleterre, renouvelant et confirmant ceux qui avaient été conclus entre ledit Henri et Louis XII. Londres, 5 avril 1514 ; 4 Traité pour le mariage de Louis XII avec Marie d'Angleterre, conclu à Londres, le 14 septembre 1514 ; 5 Traité conclu entre les ambassadeurs de François Ier et ceux d'Henri VIII, roi d'Angleterre, au sujet du mariage de la princesse Marie d'Angleterre avec le dauphin. Londres, 4 octobre 1518 ; 6 Traité conclu par les mêmes pour la reddition par Henri VIII à François Ier des villes de Tournay, Saint-Amand, Mortagne, etc. Londres, 4 octobre 1518 ; 7 Traité de paix et d'alliance conclu entre la France et l'Angleterre. Londres, 2 octobre 1518 ; 8 Ratification par la régente LOUISE DE SAVOIE, du traité conclu, le 30 août précédent, par ses ambassadeurs auprès d'Henri VIII, roi d'Angleterre, qui se sont engagés à payer une somme de 2 millions de couronnes d'or. Lyon, 26 septembre 1525 ; 9 Ratification par LOUISE DE SAVOIE d'un autre traité conclu par ses ambassadeurs auprès d'Henri VIII, le 30 août précédent, pour la répression des pirateries et des pillages et la réparation des dommages subis par les sujets anglais et français. Lyon, 26 septembre 1525 ; 10 Traité conclu entre François Ier, roi de France, et Henri VIII, roi d'Angleterre. « Campaigne, ez confins d'Ardres et Guynez ». 7 juin 1546 ; 11 Traité conclu en exécution du traité précédent, pour la détermination des limites des comtés de Boulogne et de Guines. Londres, 11 mars 1547 (n. s.) ; 12 Renouvellement avec Edouard VI du traité de paix et alliance conclu par François Ier avec Henri VIII, le 7 juin 1546. Londres, 11 mars 1547 (n. s.) ; 13 « Sommaire instruction pour le faict d'Angleterre. Il est deu au roy d'Angleterre, à cause du traicté de l'an VC. XXV... » ; 14 Varia ; Notes sur les traités de 1518 et 1532, par lesquels « est faicte ligue deffensive entre le roy « de France » et le roy d'Angleterre » ; « Estat abbregé du faict d'Angleterre. Et premièrement pour les deux millions de coronnes. Par le traicté de la paix... faicte à More, en aoust mil cinq cens vingtcinq... » ; Commission donnée par FRANÇOIS Ier au cardinal Du Bellay, à Pierre Remon, seigneur de Courcelles, et à Claude de Laubespine, pour traiter de la paix avec les ambassadeurs du roi d'Angleterre. « Courtignon », 30 août 1544 ; 15 Historia Eduardi IV et Richardi III, regum Angliae, « Thoma Moro authore ». Premiers mots : « Eduardus rex, ejus nominis quartus, actis vite annis quinquaginta tribus, mensibus septem, diebus sex... » ; derniers mots : « ... Qui nepoti ejus coronando fuerat destinatus »

James VI of Scotland Letter, 1579

This letter authorizes William Hamilton of Portmollart to repair to Edinburgh notwithstanding the acts discharging the Hamiltons from being within six miles of the King’s person. James VI and James I (June 19, 1566 – March 27, 1625) was King of Scots as James VI from July 24th, 1567 and King of England and Ireland as James I from the union of the English and Scottish crowns on March 24, 1603 after the passing of Elizabeth I.

Indenture between Richard Leonard, sheriff of the District of Niagara (regarding lands seized from John Donald McKay) to Robert Dickson

Indenture between Richard Leonard, sheriff of the District of Niagara (regarding lands seized from John Donald McKay) to Robert Dickson. The land consists of ½ an acre located in Lot no. 96 in the Town of Niagara – instrument no. 8600. This was recorded on May 4th, 1832 in Book N, folio 276- 277 in the registry of Lincoln and Haldimand Counties, Oct. 13, 1824.

The popular history of England

UANL

Structural and spectral studies of novel Co(III) complexes of N(4)-substituted thiosemicarbazones derived from pyridine-2-carbaldehyde

Seven bis(ligand) Co(III) complexes {[CoL21] NO3 · H2 O (1), [CoL21] Cl · 2 H2 O (2),[CoL21] ClO4 (3), [CoL22] NO3 (4), [CoL22] Cl · 2 H2 O (5), [CoL23] Br · 2 H2 O (6), [CoL23] ClO4 · H2 O (7)} of three thiosemicarbazone ligands {pyridine-2-carbaldehyde-N(4)-p-methoxyphenyl thiosemicarbazone [HL1], pyridine-2-carbaldehyde-N(4)-2-phenylethyl thiosemicarbazone [HL2] and pyridine-2-carbaldehyde-N(4)-(methyl),N(4)-(phenyl) thiosemicarbazone [HL3]} were synthesized and physico-chemically characterized. All complexes are assigned octahedral geometries on the basis of spectral studies. The ligands deprotonate and coordinate by means of pyridine nitrogen, azomethine nitrogen, and thiolate sulfur atoms. The single crystal X-ray structures of HL3 and two nitrate compounds are discussed. The structural studies corroborate the spectral characterization.

Key Stage Three Shakespeare : Richard III. 'Etapa Clave Tres Shakespeare : Ricardo III'.

Este texto guiado ayuda a los alumnos de la etapa 3 de secundaria (Key Stage 3) en la comprensión de este texto. Para ello, les orienta sobre el contexto histórico, los temas tratados y los personajes que aparecen en la obra de teatro.