976 resultados para Rho kinases


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Progressus Ordinis Clericorum Regularium ab anno XXIV ..., p. 216-218 ; Progressiones Societatis Iesu ab anno XXXIX ..., p. 219-241.

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Mode of access: Internet.

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Mode of access: Internet.

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Mode of access: Internet.

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Includes bibliographical references.

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Chiefly tables.

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Thesis (doctoral)--

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University of Illinois bookplate: "From the library of Conte Antonio Cavagna Sangiuliani di Gualdana Lazelada di Bereguardo, purchased 1921".

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On t. p., p̳ is subscript.

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The large number of protein kinases makes it impractical to determine their specificities and substrates experimentally. Using the available crystal structures, molecular modeling, and sequence analyses of kinases and substrates, we developed a set of rules governing the binding of a heptapeptide substrate motif (surrounding the phosphorylation site) to the kinase and implemented these rules in a web-interfaced program for automated prediction of optimal substrate peptides, taking only the amino acid sequence of a protein kinase as input. We show the utility of the method by analyzing yeast cell cycle control and DNA damage checkpoint pathways. Our method is the only available predictive method generally applicable for identifying possible substrate proteins for protein serine/threonine kinases and helps in silico construction of signaling pathways. The accuracy of prediction is comparable to the accuracy of data from systematic large-scale experimental approaches.

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