An overview of recent advances in structural bioinformatics of protein-protein interactions and a guide to their principles

Rich data bearing on the structural and evolutionary principles of protein protein interactions are paving the way to a better understanding of the regulation of function in the cell. This is particularly the case when these interactions are considered in the framework of key pathways. Knowledge of the interactions may provide insights into the mechanisms of crucial `driver' mutations in oncogenesis. They also provide the foundation toward the design of protein protein interfaces and inhibitors that can abrogate their formation or enhance them. The main features to learn from known 3-D structures of protein protein complexes and the extensive literature which analyzes them computationally and experimentally include the interaction details which permit undertaking structure-based drug discovery, the evolution of complexes and their interactions, the consequences of alterations such as post-translational modifications, ligand binding, disease causing mutations, host pathogen interactions, oligomerization, aggregation and the roles of disorder, dynamics, allostery and more to the protein and the cell. This review highlights some of the recent advances in these areas, including design, inhibition and prediction of protein protein complexes. The field is broad, and much work has been carried out in these areas, making it challenging to cover it in its entirety. Much of this is due to the fast increase in the number of molecules whose structures have been determined experimentally and the vast increase in computational power. Here we provide a concise overview. (C) 2014 Elsevier Ltd. All rights reserved.

Recent advances in the preparation of nanocrystal solids

Colloidal chemistry offers several tools to synthesize and manipulate nanoscopic objects. Despite the existence of a plethora of tools to design building blocks, methods for assembling these components into functional macroscopic materials are still in their infancy. This review discusses the recent progress made towards assembling rudimentary nanoscale building blocks into functional macroscopic materials.

Recent advances in purely organic phosphorescent materials

Luminescent organic materials have attracted significant attention in recent times owing to their opportunities in various functional applications. Interestingly, unlike fluorescence, opportunities hidden within the phosphorescence properties of organic compounds have received considerably less attention even until last few years. It is only in the second decade of the 21st century, within a time span of less than last 5 years, that the concepts and prospects of organic compounds as phosphorescent materials have evolved rapidly. The previously perceived limitations of organic compounds as phosphorescent materials have been overcome and several molecules have been designed using old and new concepts, such as heavy atom effects, matrix assisted isolation, hydrogen bonding and halogen bonding, thereby gaining access to a significant number of materials with efficient phosphorescent features. In addition, significant improvements have been made in the development of RTP (room temperature phosphorescent) materials, which can be used under ambient conditions. In this review, we bring together the vastly different approaches developed by various researchers to understand and appreciate this recent revolution in organic luminescent materials.

Recent freshwater Ostracoda and Bivalvia from Indo-Nepal border (Tethys Himalaya): Ecological implications

We report for the first time Recent ostracods and bivalves from Central Tethys Himalaya, collected from Changru village, which is situated in the Tinker valley of northwestern Nepal near the Indo-Nepal border. The specimens were collected from the surface sediments of a small pond, shaped by a small tributary of the glacier fed Tinker River. The ostracod species belonging to the families Ilyocyprididae, Cyprididae and Candonidae and one bivalve (Pisidium sp., Family Pisidiidae) have been identified. Psychrodromus olivaccus and Potamocypris villosa are being reported for the first time from India and Nepal. Several broken and unidentifiable gyrogonites of charophyta were also recovered. The ostracod sample, as a whole, points to a shallow freshwater lake environment influenced by slowly running carbonate rich waters under cool temperatures, low mineralization and sparse vegetation. This is in accordance with the occurrence of Pisidium, which is commonly associated with ostracods in the freshwater lakes and streams. The ostracod fauna shows affinity with the fossil and extant forms recovered from the Higher and Tethys Himalaya of NW India. This opens a new opportunity for studying ostracods in the Indian Central Himalaya - a region which otherwise has been ignored until now.

Recent advances in engineering topography mediated antibacterial surfaces

The tendency of bacterial cells to adhere and colonize a material surface leading to biofilm formation is a fundamental challenge underlying many different applications including microbial infections associated with biomedical devices and products. Although, bacterial attachment to surfaces has been extensively studied in the past, the effect of surface topography on bacteria-material interactions has received little attention until more recently. We review the recent progress in surface topography based approaches for engineering antibacterial surfaces. Biomimicry of antibacterial surfaces in nature is a popular strategy. Whereas earlier endeavors in the field aimed at minimizing cell attachment, more recent efforts have focused on developing bactericidal surfaces. However, not all such topography mediated bactericidal surfaces are necessarily cytocompatible thus underscoring the need for continued efforts for research in this area for developing antibacterial and yet cytocompatible surfaces for use in implantable biomedical applications. This mini-review provides a brief overview of the current strategies and challenges in the emerging field of topography mediated antibacterial surfaces.

Peptide delta-Turn: Literature Survey and Recent Progress

Among the various types of a-peptide folding motifs, delta-turn, which requires a central cis-amide disposition, has been one of the least extensively investigated. In particular, this main-chain reversal topology has been studied in-depth neither in linear/cyclic peptides nor in proteins. This Minireview article assembles and critically analyzes relevant data from a literature survey on the d-turn conformation in those compounds. Unpublished results from recent conformational energy calculations and a preliminary solution-state analysis on a small model peptide, currently ongoing in our laboratories, are also briefly outlined.

Pool Boiling In Microgravity: Recent Results And Perspectives For The Project Depa-Sj10

Two research projects on pool boiling in microgravity have been conducted aboard the Chinese recoverable satellites. Ground-based experiments have also been performed both in normal gravity and in short-term microgravity in the Drop Tower Beijing. Steady boiling of R113 on thin platinum wires was studied with a temperature-controlled heating method, while quasi-steady boiling of FC-72 on a plane plate was investigated with an exponentially increasing heating voltage. In the first case, slight enhancement of heat transfer is observed in microgravity, while diminution is evident for high heat flux in the second one. Lateral motions of bubbles on the heaters are observed before their departure in microgravity. The surface oscillation of the merged bubbles due to lateral coalescence between adjacent bubbles drives it to detach from the heaters. The Marangoni effect on the bubble behavior is also discussed. The perspectives for a new project DEPA-SJ10, which has been planned to be flown aboard the Chinese recoverable satellite SJ-10 in the future, are also presented.

Labor Market Assimilation of Recent Immigrants in Spain

Revised: 2006-11.-- Published as an article in: British Journal of Industrial Relations, June 2007, vol. 45, issue 2, pp. 257-284.

Report of the Study Group on “ Fisheries and Ecosystem Response to Recent Regime Shifts”

EXECUTIVE SUMMARY 1. DECADAL-SCALE CLIMATE EVENTS 1.1 Introduction 1.2 Basin-scale Patterns 1.3 Long Time Series in the North Pacific 1.4 Decadal Climate Variability in Ecological Regions of the North Pacific 1.5 Mechanisms 1.6 References 2. COHERENT REGIONAL RESPONSES 2.1 Introduction 2.2 Central North Pacific (CNP) 2.3 California Current System (CCS) 2.4 Gulf of Alaska (GOA) 2.5 Bering Sea and Aleutian Islands 2.6 Western North Pacific (WNP) 2.7 Coherence in Regional Responses to the 1998 Regime Shift 2.8 Climate Indicators for Detecting Regime Shifts 2.9 References 3. IMPLICATIONS FOR THE MANAGEMENT OF MARINE RESOURCES 3.1 Introduction 3.2 Response Time of Biota to Regime Shifts 3.3 Response Time of Management to Regime Shifts 3.4 Provision of Stock Assessment Advice 3.5 Decision Rules 3.6 References 4. SUGGESTED LITERATURE 4.1 Climate Regimes 4.2 Impacts on Lower Trophic Levels 4.3 Impacts on Fish and Higher Trophic Levels 4.4 Impacts on Ecosystems and Possible Mechanisms 4.5 Regimes and Fisheries Management APPENDIX 1: RECENT ECOSYSTEM CHANGES IN THE CENTRAL NORTH PACIFIC A1.1 Introduction A1.2 Physical Oceanography A1.3 Lower Trophic Levels A1.4 Invertebrates A1.5 Fishes A1.6 References APPENDIX 2: RECENT ECOSYSTEM CHANGES IN THE CALIFORNIA CURRENT SYSTEM A2.1 Introduction A2.2 Physical Oceanography A2.3 Lower Trophic Levels A2.4 Invertebrates A2.5 Fishes A2.6 References APPENDIX 3: RECENT ECOSYSTEM CHANGES IN THE GULF OF ALASKA A3.1 Introduction A3.2 Physical Oceanography A3.3 Lower Trophic Levels A3.4 Invertebrates A3.5 Fishes A3.6 Higher Trophic Levels A3.7 Coherence in Gulf of Alaska Fish A3.8 Combined Standardized Indices of Recruitment and Survival Rate A3.9 References APPENDIX 4: RECENT ECOSYSTEM CHANGES IN THE BERING SEA AND ALEUTIAN ISLANDS A4.1 Introduction A4.2 Bering Sea Environmental Variables and Physical Oceanography A4.3 Bering Sea Lower Trophic Levels A4.4 Bering Sea Invertebrates A4.5 Bering Sea Fishes A4.6 Bering Sea Higher Trophic Levels A4.7 Coherence in Bering Sea Fish Responses A4.8 Combined Standardized Indices of Bering Fish Recruitment and Survival Rate A4.9 Aleutian Islands A4.10 References APPENDIX 5: RECENT ECOSYSTEM CHANGES IN THE WESTERN NORTH PACIFIC A5.1 Introduction A5.2 Sea of Okhotsk A5.3 Tsushima Current Region and Kuroshio/Oyashio Current Region A5.4 Bohai Sea, Yellow Sea, and East China Sea A5.5 References (168 page document)