Análise tomográfica, histológica, histométrica e imunoistoquímica do beta tricálcio fosfato com osso autógeno em aumento do soalho de seio maxilar

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo comparativo do processo de reparo utilizando osso autógeno e beta-tricálcio fosfato em levantamento do assoalho do seio maxilar em humanos: análise tomográfica, histológica, histométrica e imunoistoquímica

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Bony fishes (Teleostei) caught by small-scale fisheries off central to south coast of São Paulo State, Southeastern Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise das resistências de embutimento e de compressão para madeiras de pinus e eucalipto

The connections in the wood structures are the places with high concentrations of stresses and therefore are more fragile than the rest of the structure. The connections between pieces of wood can be made by metal pins (nails or screws). The compression and embedment strength has significant influence on the calculation of the connections. The main aim of this work was to evaluate the compression and embedment strength in the directions parallel, inclined at 45° and normal to the grain, using standard specimens according to ABNT NBR 7190/1997 standard. The compression and embedment strength were initially evaluated according to ABNT NBR 7190/1997, which admits the deformation of 2‰ as limit of embedment and the ratio between the ultimate strength and the area of application of load in the specimen for the compressive strength. Afterward, the embedment strength was evaluated by the EUROCEDE 5 /1995 European standard, which use the limit of 5 mm of the displacement for the embedment. Specimens of Pinus oocarpa, Cumaru and Pinus taeda were used in tests to calibration of equipment and specimens of Pinus taeda and Eucalipto citriodora were used to compare the results of strength. The results of strength were evaluated based on statistical analysis. The results of compressive strength for the Pinus taeda showed no significant differences in embedment strength in the directions parallel and normal to the grain. For the Eucalipto citriodora only in the direction parallel to grain the compression strength was not significant compared with the embedment strength. For both species, only the parallel compression strength and inclined at 45o to the grain, which were to the grain, which were admitted the strain of 2‰ were not significantly different compared with the compression strength determined according to ABNT NBR 7190/1997. The normal compression strength obtained according to ABNT NBR 7190/1997 and ultimate compression strength not ...

Scaffolds de polihidroxibutirato construídos por prototipagem rápida funcionalizados com hidroxiapatita e peptídeo osteogênico

Com a evolução da engenharia tecidual novos materiais estão sendo estudados visando o tratamento de defeitos ósseos. O objetivo deste projeto foi preparar e caracterizar scaffolds a base de polihidroxibutirato (PHB), apatita e peptídeo osteogênico, osteogenic growth peptide (OGP), para aplicação em reparação óssea. Além disso, avaliar a liberação prolongada do peptídeo incorporado aos scaffolds na forma livre ou incorporado a lipossomas. Os scaffolds de PHB foram confeccionados por prototipagem rápida (PR) empregando a tecnologia Selective Laser Sintering (SLS). Posteriormente, a apatita foi incorporada in situ por meio de ciclos alternados de imersão em soluções de CaCl2 e Na2HPO4, respectivamente. Neste estudo foram selecionadas 2 marcações para o OGP, uma com 5,6-carboxifluoresceína (CF) e outra com triptofano (W), para análise de liberação prolongada. Os peptídeos foram incorporados ao sistema de liberação no momento de seu preparo. A caracterização por espalhamento de luz dos sistemas de liberação desenvolvidos mostrou que os peptídeos marcados com CF foram os melhores desenvolvidos. Portanto estes peptídeos foram adsorvidos nos scaffolds de PHB-CaP. Estudos in vitro foram realizados para avaliar o perfil de liberação do peptídeo OGP-CF do sistema de liberação controlada. A incorporação da apatita às matrizes de PHB foi confirmada por análises de microscopia eletrônica de varredura/ espectroscopia de energia dispersiva (MEV/EDS), espectroscopia na região do infravermelho (FTIR), absorção atômica, a difratometria de raios-X (DRX). Estas análises sugeriram que a principal fase precipitada foi -TCP. O sistema de liberação lipossoma/OGP-CF foi caracterizado pelas análises de dicroísmo circular e espalhamento de luz, que confirmaram a presença do peptídeo nas amostras. Após a análise da liberação, observou-se que o sistema PHB-CaP/OGP-CF obteve ...

Aspectos reprodutivos e sociais e resistência óssea em ratos machos submetidos ao exercício físico e/ou a um anabolizante esteróide

Nowadays the regular practice of sports is known as a way to obtain a better quality of life. On the other hand, the media has been distorting this idea, determining the ideal body as the hypertrophy phenotype. It is well known that the genetic factor does not allow all individuals to have this body shape. Besides the fact that, the anxiety of these people in obtain quick results, as one of the globalization’s consequence, make use of anabolic steroid to achieve this goal. However the bodybuilding or the strength muscle gain, make anabolic steroids users abuse and in major cases the users do not know the side effects. In front of these considerations, the present study evaluated the effects of the treatment with anabolic steroids and/or high intensity physical training on the corporal developing, the reproductive organs, bone parameters (strength and bone deformation) and seminal parameters as well the social behavior (aggressiveness). In other to obtain the experimental group, male Wistar rats were used, with 75 days old. The groups were divided into: Vehicle Non-Training (NV), Anabolic Steroid-Non-Training (NA), Vehicle-Training (TV) and Anabolic Steroid-Training (TA). These rats received i.m. injections, twice a week, of anabolic steroid (5mg/kg per animal of nandrolona decanoate) or vehicle (the same volume of peanut oil per animal) and the group TV and TA were submitted to physical training three times per week, during eight weeks. The body mass, wet weight of reproductive organs, femur and semen of the different groups were measured. The aggressive test was also realized in two steps: the first, within 4 weeks of the treatment and the other step in the end of the treatment, in this period the animal was isolated. It was not observed alterations in body mass of the groups. Though it was observed a benefic effect on the maximum strength of the... (Complete abstract click electronic access below)

Estudos citogenéticos de mutações na transformação de neoplasias benignas em malignas do sistema musculoesquelético

O câncer tem sido alvo de incessantes pesquisas sobre sua etiologia, desenvolvimento, progresso e tratamentos. Sua importância no campo científico se dá pela sua alta taxa de mortalidade e morbidade. O fato de que seja uma doença genética, que pode ter interferência ambiental e dietética, está cada vez mais elucidado, porém ainda existem muitos mecanismos a serem desvendados. As neoplasias ósseas, benignas ou malignas, e processos inflamatórios ósseos acometem desde crianças até adultos e idosos, podendo causar danos físicos, incapacidade motora e até a morte. Portanto, presumir o potencial de transformação maligna das lesões benignas, agressividade tumoral, capacidade de invasão tecidual, probabilidade de recidiva, propensão ao desenvolvimento de metástases e resposta ao tratamento, é um valioso expediente na escolha da proposta terapêutica. Estudos genéticos e citogenéticos têm ajudado a aumentar o entendimento sobre a carcinogênese, progressão tumoral, prognósticos e diagnósticos. Portanto, este estudo teve como objetivo detectar mutações e marcadores cromossômicos consistentes e recorrentes na transformação de tumores benignos em malignos no sistema musculoesquelético, através de análises com citogenética clássica, e relacionar estes achados com o prognóstico e diagnóstico dos pacientes. Dentre os casos coletados e analisados citogeneticamente, foram selecionados três casos de lesões ósseas benignas e três lesões ósseas malignas tidas como a progressão tumoral dos respectivos casos benignos, para discussão e relato de caso. Os achados citogenéticos relataram consistentes alterações numéricas e estruturais clonais em regiões cromossômicas com genes importantes envolvidos na progressão tumoral. Pode-se citar a perda da região contendo o gene TP53, supressor tumoral, tanto em lesões benignas como em maligna, como um dos achados mais relevantes neste estudo. Dessa forma, os resultados ...

Extensometria: estudo das microdeformações ao redor de três implantes de hexágono interno, com posicionamento linear, sob a influência da fundição de coifas plásticas e usinadas

The objective of this in vitro study was quantify the micro strain development around the internal hexagon implants, varying the type of prosthetic coping. For This reason, three implants of internal hexagon were inserted into one polyurethane block in line placement. Microunit abutments were screwed onto the implants. Tangentially the implants were bonded the strain gauges, two to the center implant. Ten structures, each one containing three copings were cast in Co-Cr alloy, that were divided into groups in the first group, plastic copings were used, and in the second group machined copings were used. The superstructure’s occlusal screws were tightened onto Microunit abutments with 10 Ncm torque, the magnitude of micro strain was recorded. The mean values of each strain gauge of each plastic copings were 363,37 ± 237,66 and the machined copings were 338,12 ± 223,01. The data were analyzed statistically by t- Student test. No statistically significant difference was found between the prosthetic copings (p= 0,867). It was concluded that to internal hexagon implants in line placement, the type of copings presented similar magnitude of micro strain after prosthetic occlusal screw was tightened

Síntese de membranas à base de híbridos orgânico-inorgânicos para implantes odontológicos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Aplicação de adesivos estruturais em painéis de carros

The automobile industry is increasingly interested in reducing vehicle weight for greater speed, lower fuel consumption and emissions, through innovation of materials and processes. One way to do this is to seek the replacement of conventional processes by the use of structural adhesives. Structural adhesives are highly resistant materials, which can replace rivets, bolts and welds allowing the substrate / adhesive assemble is stronger than the substrate itself. One of the major advantages of gluing with respect to welding is its esthetic appearance, since it does not leave marks. For this reason, parts to be soldered require a minimum thickness so that the marks do not appear, since the pieces from gluing have no restriction as to the thickness. By replacing the vibration welding process for gluing process of the instrument panel parts of an automobile, one obtains a reduction of the thickness of the parts and therefore it decreases the weight of the car. This work aims to study the various structural adhesives that already exist on the market to be applied on the instrument panel. The mechanical test performed to measure the maximum adhesive strength was the Lap Shear Test at 23°C (room temperature), -35°C and 85°C. The types of adhesives used were the hot-melt and the bi-component. By the results obtained, it is in favor using the bi-component for application to the union of instrument panel parts

Crescimento de apatita na superfície da liga Ti-25Ta empregando dois tipos de tratamento de superfície: biomimético e deposição de polímero por eletrofiação

Titanium and its alloys has been widely used as materials for metallic biomaterials implants are usually employed to restore the hard tissue function, being used for artificial joints and bones, synthetic plates, crowns, dental implants and screws . Objective of this work was the surface modification of Ti-alloy 25Ta from biomimetic surface treatment of employment and deposition of polymer by electrospinning. The league was obtained from the fusion of the pure elements in the arc furnace with controlled atmosphere. The ingots were subjected to heat treatment, cold forged and sectioned discs with 13 mm diameter and 3 mm thick. Two surface treatments was evaluated, biomimetic and electrospinning with PCL fiber. The biomimetic treatment was performed involving alkaline treatment for three molarities 1.5M, 3M and 5M with immersion in SBF. The electrospinning was performed using PCL polymer alloy surface after the alkali treatment Ti25Ta 1M. For this group the polymer coated surfaces were immersed in calcium phosphate containing solution for immobilization of apatite. The results were compared with previous studies using surface treatment group to verify hydroxyapatite formation on the sample surface and it is concluded that the best condition is biomimetic treatment with 5M alkali treatment and heat treatment at 80 ° C for 72 hours

Análise das microdeformações geradas ao redor de implantes de hexágono externo sob a aplicação de cargas verticais em pilares microunit retos e angulados

Pós-graduação em Odontologia Restauradora - ICT

Influência de diferentes superfícies de implantes unitários com geometria do tipo hexágono externo, Platform Switching e Cone-Morse em osso tipo III e IV: estudo pelo método dos elementos finitos tridimensionais

Pós-graduação em Odontologia - FOA

Análise das tensões em próteses implantossuportadas esplintadas, variando a localização dos implantes, pôntico e cantilever: estudo pelo método dos elementos finitos tridimensionais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Desenvolvimento de parafuso de interferência bioabsorvível para cirurgia de joelho em PLDL (poli ácido lático) e compósito PLDL + βTCP (beta trifosfato de cálcio)

Pós-graduação em Engenharia Mecânica - FEB