Effects of zoledronate versus placebo on spine bone mineral density and microarchitecture assessed by the trabecular bone score in postmenopausal women with osteoporosis: A three-year study.

The trabecular bone score (TBS) is an index of bone microarchitectural texture calculated from anteroposterior dual-energy X-ray absorptiometry (DXA) scans of the lumbar spine (LS) that predicts fracture risk, independent of bone mineral density (BMD). The aim of this study was to compare the effects of yearly intravenous zoledronate (ZOL) versus placebo (PLB) on LS BMD and TBS in postmenopausal women with osteoporosis. Changes in TBS were assessed in the subset of 107 patients recruited at the Department of Osteoporosis of the University Hospital of Berne, Switzerland, who were included in the HORIZON trial. All subjects received adequate calcium and vitamin D3. In these patients randomly assigned to either ZOL (n = 54) or PLB (n = 53) for 3 years, BMD was measured by DXA and TBS assessed by TBS iNsight (v1.9) at baseline and 6, 12, 24, and 36 months after treatment initiation. Baseline characteristics (mean ± SD) were similar between groups in terms of age, 76.8 ± 5.0 years; body mass index (BMI), 24.5 ± 3.6 kg/m(2) ; TBS, 1.178 ± 0.1 but for LS T-score (ZOL-2.9 ± 1.5 versus PLB-2.1 ± 1.5). Changes in LS BMD were significantly greater with ZOL than with PLB at all time points (p < 0.0001 for all), reaching +9.58% versus +1.38% at month 36. Change in TBS was significantly greater with ZOL than with PLB as of month 24, reaching +1.41 versus-0.49% at month 36; p = 0.031, respectively. LS BMD and TBS were weakly correlated (r = 0.20) and there were no correlations between changes in BMD and TBS from baseline at any visit. In postmenopausal women with osteoporosis, once-yearly intravenous ZOL therapy significantly increased LS BMD relative to PLB over 3 years and TBS as of 2 years. © 2013 American Society for Bone and Mineral Research.

The clinical use of quantitative ultrasound (QUS) in the detection and management of osteoporosis

For the detection and management of osteoporosis and osteoporosis-related fractures, quantitative ultrasound (QUS) is emerging as a relatively low-cost and readily accessible alternative to dual-energy X-ray absorptiometry (DXA) measurement of bone mineral density (BMD) in certain circumstances. The following is a brief, but thorough review of the existing literature with respect to the use of QUS in 6 settings: 1) assessing fragility fracture risk; 2) diagnosing osteoporosis; 3) initiating osteoporosis treatment; 4) monitoring osteoporosis treatment; 5) osteoporosis case finding; and 6) quality assurance and control. Many QUS devices exist that are quite different with respect to the parameters they measure and the strength of empirical evidence supporting their use. In general, heel QUS appears to be most tested and most effective. Overall, some, but not all, heel QUS devices are effective assessing fracture risk in some, but not all, populations, the evidence being strongest for Caucasian females over 55 years old. Otherwise, the evidence is fair with respect to certain devices allowing for the accurate diagnosis of likelihood of osteoporosis, and generally fair to poor in terms of QUS use when initiating or monitoring osteoporosis treatment. A reasonable protocol is proposed herein for case-finding purposes, which relies on a combined assessment of clinical risk factors (CR.F) and heel QUS. Finally, several recommendations are made for quality assurance and control.

Los referentes culturales y su tratamiento en la traducción del manga: los casos de La espada del inmortal, GALS!, Vidas etílicas y Ranma ½

L’objecte d’estudi d’aquesta investigació és l’observació i categorització dels referents culturals que apareixen en obres manga (còmic japonès) i la descripció del tractament que reben els elements esmentats en les versions traduïdes. Es tracta d’un estudi sincrònic de la traducció del primer volum de quatre obres publicades a España en castellà: La espada del inmortal, GALS!, Vidas etílicas i Ranma ½. Cadascun d’ells s’ha escollit per pertànyer a un gènere de manga dirigit a un segment de la població japonesa determinat: seinen (homes), shôjo (nenes-noies), jôsei (dones) y shônen (nens-nois)

Prevalencia, impacto y tratamiento psicológico grupal de los trastornos de ansiedad : una revisión en el ámbito de la atención primaria

Este trabajo recopila y discute información publicada sobre el estado actual de la prevalencia, impacto y abordaje grupal de los trastornos de ansiedad. El objetivo es estar actualizado sobre los últimos conocimientos y tendencias en la materia y promover la investigación de un modelo integrado de atención entre los profesionales de la Atención Primaria y los servicios especializados. Se ha realizado una búsqueda bibliográfica en las bases de datos PSYCHOINFO y MEDLINE, dónde se encuentran las revistas que normalmente publican artículos sobre dicha especialidad y se ha realizado una discusión sobre los mismos con especialistas que trabajan en los servicios de la Salud Pública. Los datos que conocemos referentes al elevado impacto social y económico revelan la necesidad de un abordaje integral de los trastornos de ansiedad desde el punto de vista médico y psicológico como una de las principales prioridades para la Salud Mental. Se considera el formato de intervención grupal como una alternativa terapéutica eficaz y eficiente para la mayoría de diagnósticos, incluidos los trastornos de ansiedad. La valoración integrada de los síntomas y su detección precoz son fundamentales como herramienta de prevención de la Salud y de futuras demandas por trastornos más graves a los servicios especializados.

El tratamiento numérico de la realidad. Reflexiones sobre la importancia actual de la estadística en la Sociedad de la Información.

La estadística se ha convertido en un método práctico para describir los valores de datos económicos, políticos, sociales, psicológicos, médicos, biológicos y físicos, como herramienta para relacionar y analizar dichos datos. El trabajo del estadístico no consiste sólo en obtener, reunir o tabular los datos, sino sobre todo el proceso de interpretación de esa información solo o en colaboración con los expertos en cada ámbito. A pesar de que es imposible entender la Sociedad de la Información sin la estadística, es preocupante la situación actual de las ciencias matemáticas y más concretamente de la estadística, ya que a pesar de su imprescindibilidad existe una falta de vocación entre los jóvenes por su estudio y uso, ya sea por su dificultad matemática, desconocimiento u otros motivos. Este artículo pretende reflexionar sobre la importancia de la misma en la sociedad actual que permite tratar numéricamente la realidad.

La eficacia de las suspensiones judiciales con obligación de tratamiento de deshabituación. Factores que pueden influir en la reducción o no de reincidencia

Esta investigación está motivada por el interés por las suspensiones judiciales como medida más adecuada para determinados sujetos con perfiles toxicológicos y que requieren una intervención que se puede abordar en un contexto comunitario. Con el fin de valorar su eficacia, el equipo de investigadores se ha centrado en los índices de reincidencia y aquellos factores que pueden influir a partir del análisis estadístico de una muestra de 237 sujetos sometidos a la obligación de tratamiento de deshabituación. Observando el índice de reincidencia, en función del análisis de variables sociopersonales y judiciales de los sujetos, se buscan aquellos indicadores que pueden ser eficaces para reducir la comisión de nuevos hechos delictivos. De los resultados obtenidos, se concluye que variables como una buena adherencia familiar, la estabilidad laboral o la finalización correcta de un tratamiento de deshabituación aportan unos niveles de reincidencia bajos Asimismo, se justifica el otorgamiento de suspensiones judiciales como herramienta punitiva más eficaz para aquellos sujetos con características toxicológicas y necesidades rehabilitadoras debido a su adicción, dado que los niveles de reincidencia obtenidos en esta investigación aportan unos índices más bajos que los niveles actuales de reincidencia penitenciaria (siempre teniendo en cuenta la diferencia de perfiles). Se concluye en este estudio que la aplicación de estas medidas penales alternativas son una herramienta más integradora debido a que se desarrolla dentro del entorno comunitario.

Pronóstico y tratamiento de la boca seca. Revisión sistemática

No existen protocolos claramente establecidos para el tratamiento de la boca seca. El objetivo de este trabajo es realizar una revisión sistemática de la literatura médica de los últimos 10 años. Hemos utilizado las palabras: «dry mouth», «prognosis», «treatment» y «dentistry». En una primera búsqueda hemos encontrado 1.450 entradas. Con la restricción «clinical trials OR randomized controlled trial OR systemic reviews» se han reducido a 522, de las que 145 eran metaanálisis y revisiones sistemáticas. Se han eliminado las que no eran pertinentes al tema y han quedado reducidas a 53. Posteriormente se descartaron 24 (8 no pertinentes, 7 revisiones y 9 opiniones personales). De los 29 artículos analizados, 15 son ensayos clínicos controlados, 2 ensayos no controlados, 4 estudios observacionales, 2 revisiones sistemáticas y 5 revisiones. Los enfermos mejor estudiados son los pacientes con síndrome de Sjögren y los pacientes irradiados. El tratamiento se centra en el etiológico, preventivo, sintomático, de estimulación salival local y sistémicos. Podemos concluir que el tratamiento debe ser individualizado, pudiéndose aplicar sustitutos salivales y diferentes técnicas de estimulación mecánica. There are no clearly established protocols for the treatment of dry mouth. The aim of this paper is a systematic review of the literature of the past 10 years using the words «dry mouth», «prognosis», «treatment» and «dentistry». The initial search found 1,450 entries and within the restriction «clinical trials OR randomized controlled trial OR systemic reviews» it has been reduced to 522, which 145 were meta-analysis and systematic reviews. Papers not relevant to the issue were removed reducing the entries to 53. Twenty-four were dismissed (8 irrelevant, 7 reviews without adequate information and 9 personal opinions). Of the 29 items tested, 15 were controlled trials, 2 uncontrolled trials, 4 observational studies, 2 systematic reviews and 5 non systematic reviews. The most studied patients were Sjögren's syndrome and the irradiated patients. Treatments are focused on the etiology, prevention, symptomatic, local salivary stimulation and systemic treatments. It can be concluded that treatment must be individualized, salivary substitutes and mechanical stimulation techniques can be applied.

Catalogación y valoración de las webquests desde el área de educación física y el tratamiento de temáticas transversales

Gears of the current millennium have been activated by the hit entry into the information society that has generated a whole range of social and educational changes, it is difficult to stay out of their influence, such as: the dizzying presence of new technologies (NNTT) and the entrenchment of a crisis of values. Physical education has been affected by this avalanche of developments that have sparked the birth of original teaching and learning tools that can be applied in the classroom. In this sense, WebQuests have been configured as a unifying and educational activities that allow addressing the treatment of specific thematic area that we are dealing with the work of certain cross¿cutting. But how do you know what product we have before us, what is its effectiveness? What criteria will allow us to classify it as a fit and capable of being applied in our particular educational context? To clarify these and other issues that any teacher could arise before the election of a multimedia educational materials, our particular object of study has a double claim on the one hand, developing two tools: the card catalog and the heading of Valuation of WebQuests and secondly, to apply these tools in order to find out / determine the degree of quality of a sample of WebQuests. In this article sets forth, in summary form, the various stages of what our research has gone since the establishment of a synthesized theoretical basis, via the definition of the basic guidelines for the design of the exhibition and research results and ending with The list of the ideas and proposals arising from thework.

Screening fo osteoporosis in elderly patients admitted to post-acute rehabilitation.

Background: Screening for osteoporosis is important in older patients admitted to post-acute rehabilitation. However, DXA measurement is sometimes difficult to perform because of difficulties in positioning the patient and artefacts (osteoarthritis, prosthesis). The objectives were to determine the prevalence of unknown clinical osteoporosis in rehab patients and to determine new strategies for identifying clinical osteoporosis in this population. Method: Over a 9-months period, patients consecutively admitted to post-acute rehabilitation were included in th stdy. Patients with osteoporosis diagnosis, and those with terminal illness or severe physical limitations were excluded. Patients underwent Bone Mineral Density (BMD) by DXA and Vertebral Fracture Assessment (VFA). Clinical osteoporosis was defined as BMD ≤-2.5 SD at any site (lumbar spine, femoral neck, total hip or distal radius), ≥1 vertebral fracture, ≥1 hip fracture, or another fragility fracture and BMD ≤-2 SD. Results: Overall, 102 (17.0%) of the 600 patients admitted to rehab refused to participate in the study or were unable to consent. Among the 498 remaining patients, 99 (19.9%) were excluded because of already known diagnosis of osteoporosis, 101 (20.3%) were excluded because of terminal illness, severe physical limitations, and 45 (9.0%) because of inability to perform DXA during the stay (death, hospital transfer). Overall, 253 patients were assessed with DXA and VFA (166 women, mean age 83±7 years, mean BMI 27±6 kg/m2, and 87 men, mean age 82±6 yrs, mean BMI 27±5 kg/m2). Of these, 70% had history of fall during the last 6 months and 9.1% had hip fracture history. Prevalence of osteoporotic vertebral fracture was 36% in women and 32% in men. Overall, 152 (60.1%) patients had clinical osteoporosis (women: 67%; men: 46%) according to above criteria. Hip fracture history and vertebral fracture assessment identified correctly 105 (69.1%) of these 152 patients. Conclusion: A high prevalence of osteoporosis was observed in this population of rehab patients. Osteoporosis status should be systematically assessed in these patients at high fall risk, at least with careful history of hip fracture and an assessment for vertebral fractures with spine X-ray.

Utility of the trabecular bone score (TBS) in secondary osteoporosis.

Altered bone micro-architecture is an important factor in accounting for fragility fractures. Until recently, it has not been possible to gain information about skeletal microstructure in a way that is clinically feasible. Bone biopsy is essentially a research tool. High-resolution peripheral Quantitative Computed Tomography, while non-invasive, is available only sparsely throughout the world. The trabecular bone score (TBS) is an imaging technology adapted directly from the Dual Energy X-Ray Absorptiometry (DXA) image of the lumbar spine. Thus, it is potentially readily and widely available. In recent years, a large number of studies have demonstrated that TBS is significantly associated with direct measurements of bone micro-architecture, predicts current and future fragility fractures in primary osteoporosis, and may be a useful adjunct to BMD for fracture detection and prediction. In this review, we summarize its potential utility in secondary causes of osteoporosis. In some situations, like glucocorticoid-induced osteoporosis and in diabetes mellitus, the TBS appears to out-perform DXA. It also has apparent value in numerous other disorders associated with diminished bone health, including primary hyperparathyroidism, androgen-deficiency, hormone-receptor positive breast cancer treatment, chronic kidney disease, hemochromatosis, and autoimmune disorders like rheumatoid arthritis. Further research is both needed and warranted to more clearly establish the role of TBS in these and other disorders that adversely affect bone.

Pédiatrie 5. Approche ciblée de l'ostéoporose chez l'enfant et l'adolescent [Targeted approach to osteoporosis for children and teenagers].

The osteoporosis of the child and the teenager is a pathological reality; its multifactorial pathogenesis often requires a collaborative approach and multidisciplinary. The osteoporosis characterized by a reduction in the bone mineral density is not a uniform pathology; it must be dealt with on all the levels by analyzing the factors of risks, by giving itself the diagnostic means and while insisting on the importance of a preventive approach as well as therapeutic.

Early diagnosis of osteoporosis by means of orthopantomograms and oral x-rays: a systematic review

Osteoporosis is a systemic bone disease that is characterized by a generalized reduction of the bone mass. It is the main cause of fractures in elderly women. Bone densitometry is used in the lumbar spine and hip in order to detect osteoporosis in its early stages. Different studies have observed a correlation between the bone mineral density of the jaw (BMD) and that of the lumbar spine and/or hip. On the other hand, there are studies that evaluate the findings in the orthopantomograms and perapical X-rays, correlating them with the early diagnosis of osteoporosis and highlighting the role of the dentist in the early diagnosis of this disease. Materials and methods: A search was carried out in the Medline-Pubmed database in order to identify those articles that deal with the association between the X-ray findings observed in the orthopantomograms and the diagnosis of the osteoporosis, as well as those that deal with the bone mineral density of the jaw. Results: There were 406 articles, and with the limits established, this number was reduced to 21. Almost all of the articles indicate that when examining oral X-rays, it is possible to detect signs indicative of osteoporosis. Discussion: The radiomorphometric indices use measurements in orthopantomograms and evaluate possible loss of bone mineral density. They can be analyzed alone or along with the visual indices. In the periapical X-rays, the photodensimetric analyses and the trabecular pattern appear to be the most useful. There are seven studies that analyze the densitometry of the jaw, but only three do so independently of the photodensitometric analysis. Conclusions: The combination of mandibular indices, along with surveys on the risk of fracture, can be useful as indicators of early diagnosis of osteoporosis. Visual and morphometric indices appear to be especially important in the orthopantomograms. Photodensitometry indices and the trabecular pattern are used in periapical X-rays. Studies on mandibular dual-energy X-ray absorptiometry are inconclusive

Repercusiones de la anorexia y la bulimia en la salud oral, prevención y tratamiento

El presente artículo trata de aportar una puesta al día de los problemas que presentan los pacientes afectados de anorexia y de bulimia nerviosa. Se expone la información que el odontólogo debe tener en cuenta respecto al conocimiento de la enfermedad, sus manifestaciones orales, los criterios diagnósticos y los enfoques preventivos y terapéuticos necesarios.

Official Positions for FRAX® clinical regarding prior fractures from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®.

The 2010 Position Development Conference addressed four questions related to the impact of previous fractures on 10-year fracture risk as calculated by FRAX(®). To address these questions, PubMed was searched on the keywords "fracture, epidemiology, osteoporosis." Titles of retrieved articles were reviewed for an indication that risk for future fracture was discussed. Abstracts of these articles were reviewed for an indication that one or more of the questions listed above was discussed. For those that did, the articles were reviewed in greater detail to extract the findings and to find additional past work and citing works that also bore on the questions. The official positions and the supporting literature review are presented here. FRAX(®) underestimates fracture probability in persons with a history of multiple fractures (good, A, W). FRAX(®) may underestimate fracture probability in individuals with prevalent severe vertebral fractures (good, A, W). While there is evidence that hip, vertebral, and humeral fractures appear to confer greater risk of subsequent fracture than fractures at other sites, quantification of this incremental risk in FRAX(®) is not possible (fair, B, W). FRAX(®) may underestimate fracture probability in individuals with a parental history of non-hip fragility fracture (fair, B, W). Limitations of the methodology include performance by a single reviewer, preliminary review of the literature being confined to titles, and secondary review being limited to abstracts. Limitations of the evidence base include publication bias, overrepresentation of persons of European descent in the published studies, and technical differences in the methods used to identify prevalent and incident fractures. Emerging topics for future research include fracture epidemiology in non-European populations and men, the impact of fractures in family members other than parents, and the genetic contribution to fracture risk.