The Amplifier - v. 6, no. 14

In this issue...Copper Lounge, Union Pacific Railway, Air Force, Circle K Club, Petroleum Engineers, Montana Power Company, Historical Geology Field Trip, Lime Spur Quarry

The Amplifier - v. 8, no. 2

In this issue...United Nations meeting, Newman Club, Sylvia White, Veteran's Day, Glee Club, Montana Power Company, Harvest Festival Dance, Joe Knuckey's Melody Makers

The Amplifier - v. 8, no. 6

In this issue...Sylvia White, Speed Skating, President Kennedy, St. John's Church, Mineral Club, Magma Yearbook, Honor roll, Montana Power Company

The Amplifier - v. 8,(a-3) no. 3

In this issue...E-days, Residence Hall, campus parking, clergy day, Finlen Hotel, Montana Power Company, Coach Simonich, Copper Guards, Bridge Club

The Amplifier - v. 8,(a-10) no. 10

In this issue...Library, Constitution, fraternities, Continental Oil Company, Circle K Club, Mineral Club, Ed Simonich, Geologists, Montana Power Company, hayride party

The Amplifier - v. 10, no. 7

In this issue...Rotary Club, ASARCO, Hootenany, Wesley Club, Ellen Hurlbut, Finlen Hotel, Silver bow County Hospital, Mountain View Church, Butte Post Office

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial.

BACKGROUND REG1 is a novel anticoagulation system consisting of pegnivacogin, an RNA aptamer inhibitor of coagulation factor IXa, and anivamersen, a complementary sequence reversal oligonucleotide. We tested the hypothesis that near complete inhibition of factor IXa with pegnivacogin during percutaneous coronary intervention, followed by partial reversal with anivamersen, would reduce ischaemic events compared with bivalirudin, without increasing bleeding. METHODS We did a randomised, open-label, active-controlled, multicentre, superiority trial to compare REG1 with bivalirudin at 225 hospitals in North America and Europe. We planned to randomly allocate 13,200 patients undergoing percutaneous coronary intervention in a 1:1 ratio to either REG1 (pegnivacogin 1 mg/kg bolus [>99% factor IXa inhibition] followed by 80% reversal with anivamersen after percutaneous coronary intervention) or bivalirudin. Exclusion criteria included ST segment elevation myocardial infarction within 48 h. The primary efficacy endpoint was the composite of all-cause death, myocardial infarction, stroke, and unplanned target lesion revascularisation by day 3 after randomisation. The principal safety endpoint was major bleeding. Analysis was by intention to treat. This trial is registered at ClinicalTrials.gov, identifier NCT01848106. The trial was terminated early after enrolment of 3232 patients due to severe allergic reactions. FINDINGS 1616 patients were allocated REG1 and 1616 were assigned bivalirudin, of whom 1605 and 1601 patients, respectively, received the assigned treatment. Severe allergic reactions were reported in ten (1%) of 1605 patients receiving REG1 versus one (<1%) of 1601 patients treated with bivalirudin. The composite primary endpoint did not differ between groups, with 108 (7%) of 1616 patients assigned REG1 and 103 (6%) of 1616 allocated bivalirudin reporting a primary endpoint event (odds ratio [OR] 1·05, 95% CI 0·80-1·39; p=0·72). Major bleeding was similar between treatment groups (seven [<1%] of 1605 receiving REG1 vs two [<1%] of 1601 treated with bivalirudin; OR 3·49, 95% CI 0·73-16·82; p=0·10), but major or minor bleeding was increased with REG1 (104 [6%] vs 65 [4%]; 1·64, 1·19-2·25; p=0·002). INTERPRETATION The reversible factor IXa inhibitor REG1, as currently formulated, is associated with severe allergic reactions. Although statistical power was limited because of early termination, there was no evidence that REG1 reduced ischaemic events or bleeding compared with bivalirudin. FUNDING Regado Biosciences Inc.

The association between maternal use of spermicides, condoms, intra-uterine devices or progesterone and major structural birth defects

Birth defects occur in 1 of every 33 babies born in the United States, and are the leading cause of infant death. Mothers using contraceptives that become pregnant may continue to use their contraceptives after their first missed menstrual period, thus exposing their baby in utero to the contraceptive product. Progesterone is also sometimes prescribed during the first trimester of pregnancy to mothers with a history of miscarriages or infertility problems. To ensure the safety of these products, it is important to investigate whether there is an increased occurrence of babies born with birth defects to mothers using various contraceptive methods or progesterone in early pregnancy. Using data from the National Birth Defects Prevention Study (NBDPS), an ongoing multi-state, population based case-control study, this study assessed maternal exposures to IUDs, spermicides, condoms and progesterone in early pregnancy. ^ Progesterone used for threatened miscarriage during the first three months of pregnancy was associated with an increased occurrence of hypoplastic left heart (adjusted odds ratios (OR) 2.24, 95% CI 1.13-4.21), perimembranous ventricular septal defects (OR 1.64, 95% CI 1.10-2.41), septal associations (OR 2.52, 95% CI 1.45-4.24), esophageal atresia (OR 1.82, 95% CI 1.04-3.08), and hypospadias (OR 2.12, 95% CI 1.41-3.18). Mothers using progesterone for injectable contraception had increased (OR > 2.5), but insignificant odds ratios for anencephaly, septal associations, small intestinal atresias and omphalocel. Progesterone used for fertility was not associated with an increased occurrence of any birth defects examined. ^ Mothers using progesterone for fertility assistance and threatened miscarriage were very similar with respect to their demographics and pregnancy history. They also both reported similar types of progesterone. Thus, if progesterone was a causal risk factor for birth defects we would have expected to observe similar increases in risk among mothers using progesterone for both indications. Because we predominantly observed increased associations among mothers using progesterone for threatened miscarriage but not fertility assistance, it is possible the increased associations we observed were confounded by indication (i.e. progesterone was administered for vaginal bleeding which occurred as a sequelae to the formation of a congenital anomaly. ^ No significant increased associations were observed between maternal spermicide use during pregnancy and 26 of 27 types of structural malformations. While multiple statistical tests were performed we observed first trimester maternal spermicide use to be associated with a significant increased occurrence of perimembranous ventricular septal defects (OR 2.21, 95% CI 1.16-4.21). A decreased occurrence (OR < 1.0) was observed for several categories of birth defects among mothers who conceived in the first cycle after discontinuing the use of spermicides (22 of 28) or male condoms (23 of 33). ^ Overall the percent of IUD use was similar between mothers of controls and mothers of all cases in aggregate (crude OR 1.05, 95% CI 0.61-1.84). Power was limited to detect significant associations between IUD use and birth defects, however mothers using an IUD in the month immediately prior to conception or during pregnancy were not associated with an increase of birth defects. Limb defects and amniotic band sequence previously reported to be associated with IUD use during pregnancy were not found to occur among any mothers reporting the use of an IUD during pregnancy.^

Eros y cultura

Es un lugar común la casi inexistente contribución de España a Ia literatura de corte erótico. Esta cuestión se relaciona, al mismo tiempo, con Ia consideración acerca de qué se considera "pornográfico". Aquí es necesario tener en cuenta, empero, en qué medida lo pornográfico implica la mirada del sujeto que lo percibe como tal. La arqueología, por su parte, ha venido dando pruebas de los cambios en la recepción de Ia iconografía antigua; y de este modo ha venido a echar cierta luz sobre la consideración de lo erótico en la misma España, donde la tabuización de Ia sexualidad por el poder eclesiástico ha acorralado lo erótico a un consumo masivo y trivial.

Eros y cultura

Es un lugar común la casi inexistente contribución de España a Ia literatura de corte erótico. Esta cuestión se relaciona, al mismo tiempo, con Ia consideración acerca de qué se considera "pornográfico". Aquí es necesario tener en cuenta, empero, en qué medida lo pornográfico implica la mirada del sujeto que lo percibe como tal. La arqueología, por su parte, ha venido dando pruebas de los cambios en la recepción de Ia iconografía antigua; y de este modo ha venido a echar cierta luz sobre la consideración de lo erótico en la misma España, donde la tabuización de Ia sexualidad por el poder eclesiástico ha acorralado lo erótico a un consumo masivo y trivial.

Eros y cultura

Es un lugar común la casi inexistente contribución de España a Ia literatura de corte erótico. Esta cuestión se relaciona, al mismo tiempo, con Ia consideración acerca de qué se considera "pornográfico". Aquí es necesario tener en cuenta, empero, en qué medida lo pornográfico implica la mirada del sujeto que lo percibe como tal. La arqueología, por su parte, ha venido dando pruebas de los cambios en la recepción de Ia iconografía antigua; y de este modo ha venido a echar cierta luz sobre la consideración de lo erótico en la misma España, donde la tabuización de Ia sexualidad por el poder eclesiástico ha acorralado lo erótico a un consumo masivo y trivial.

Stunted and Distorted Industrialization in Myanmar

More than 15 years have passed since Myanmar embarked on its transition from a centrally planned economy to a market-oriented one. The purpose of this paper is to provide a bird-eye's view of industrial changes from the 1990s up to 2005. The industrial sector showed a preliminary development in the first half of the 1990s due to an "open door" policy and liberalization measures. However, a brief period of growth failed to effect any changes in the economic fundamentals. The industrial sector still suffers from poor power supplies, limited access to imported raw materials and machinery, exchange rate instability, limited credit, and frequent changes of government regulation. Public ownership is still high in key infrastructure sectors, and has failed to provide sufficient services to private industries. What the government must do first is to get the fundamentals right.

Coal purchase optimization: a review from Spain

The study addresses the need to manage the risk of the purchase price of coal in a power company by changing the management model of the purchasing department. It eliminates the risk of price reduces the cost of buying coal and optimizing the performance of all electricity generation plants belonging to the company. You get more flexibility and optionallity to gain additional benefits both economic and efficiency in the supply to our generation fleet. The tools to achieve the above purpose will be financial derivatives that will be used as elements of management and not as mere speculation in the markets.

The government Europe deserves? CEPS Commentary, 17 September 2014

Leaders of the EU’s institutions have to be political entrepreneurs if they are to leave a mark on history. Their decision-making power is limited, but they can often frame the choices and broker coalitions to push the existing boundaries of European integration. This Commentary by Daniel Gros finds that none of the EU’s top three new faces – Jean-Claude Juncker, Donald Tusk or Federica Mogherini – has a track record in this sense. In his view, the most sobering message from the whole appointment process is that the member states’ leaders will not suffer anyone who might rock the boat and push integration forward. That there will be little movement towards the “ever-closer union” envisioned in the Treaty of Rome might come as a relief for those fearing domination by Brussels (like many in the UK), but it can only dismay those who hope that, despite its sluggish economy and declining population, Europe can become a relevant global actor.

Las cuestiones del Putumayo; declaraciones prestadas ante el Comité de investigación de la Cámara de los comunes y debidamente anotadas,

A defense of the Peruvian Amazon company, limited.