Three generations of Therese Gottschalk nee Molling, her daughter Elizabeth Gottschalk and Grandmother Henny Molling; Hannover, Germany.

From left to right: Therese Gottschalk nee Molling, Elizabeth Gottschalk, Henny Molling

Elizabeth Krakauer nee Gottschalk conducting an experiment in a Oberprima (high school) chemistry laboratory; Sophienschule; Hannover, Germany.

This picture was taken during her last year of high school. The chemistry teacher, Professor Schmigielski was one of Elizabeth's favorite teachers.

Quantitative Trait Loci for CD4:CD8 Lymphocyte Ratio Are Associated with Risk of Type 1 Diabetes and HIV-1 Immune Control

Abnormal expansion or depletion of particular lymphocyte subsets is associated with clinical manifestations such as HIV progression to AIDS and autoimmune disease. We sought to identify genetic predictors of lymphocyte levels and reasoned that these may play a role in immune-related diseases. We tested 2.3 million variants for association with five lymphocyte subsets, measured in 2538 individuals from the general population, including CD4+ T cells, CD8+ T cells, CD56+ natural killer (NK) cells, and the derived measure CD4:CD8 ratio. We identified two regions of strong association. The first was located in the major histocompatibility complex (MHC), with multiple SNPs strongly associated with CD4:CD8 ratio (rs2524054, p = 2.1 × 10−28). The second region was centered within a cluster of genes from the Schlafen family and was associated with NK cell levels (rs1838149, p = 6.1 × 10−14). The MHC association with CD4:CD8 replicated convincingly (p = 1.4 × 10−9) in an independent panel of 988 individuals. Conditional analyses indicate that there are two major independent quantitative trait loci (QTL) in the MHC region that regulate CD4:CD8 ratio: one is located in the class I cluster and influences CD8 levels, whereas the second is located in the class II cluster and regulates CD4 levels. Jointly, both QTL explained 8% of the variance in CD4:CD8 ratio. The class I variants are also strongly associated with durable host control of HIV, and class II variants are associated with type-1 diabetes, suggesting that genetic variation at the MHC may predispose one to immune-related diseases partly through disregulation of T cell homeostasis.

Elizabeth Krakauer nee Gottschalk seated in a Oberprima (high school) chemistry laboratory; Sophienschule; Hannover, Germany.

This picture was taken during her last year of high school. The chemistry teacher, Professor Schmigielski was one of Elizabeth's favorite teachers.

Walter Gottschalk and Fritz Gottschalk (Papa) saying goodbye to Elizabeth and Hans Krakauer who are on board the ship Koenigstein leaving to emigrate to America; Antwerp, Belgium.

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Therese Gottschalk with her daughter Elizabeth outdoors; Marienbad.

Verso: addressed to Herrn u. Frau Louis Gottschalk; Hannover; Elizabeth Gottschalk, born 1911

"Klo-KU-BA", Hans and Elizabeth Krakauer's first marital apartment in the basement of the Jewish Hospital; Hannover, Germany Architecture; Residences; Interior

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Portrait of four generations of women: Henny Molling nee Meyerhof, Elizabeth Gottschalk, Julie Meyerhof nee Oppenheimer and Therese Gottschalk nee Molling Portraits; Family

From left to right: Henny Molling, born Meyerhof, Elizabeth Gottschalk, Julie Meyerhof born Oppenheimer, and Therese Gottschalk, born Molling.

Wedding portrait of Martin and Lotte Lewin Portraits Couples

Handwritten thank you note under photograph signed by Lotte Lewin dated February 6, 1935

Hans Krakauer and Elizabeth Krakauer nee Gottschalk; Boston, New York. Portraits Couples

Photograph taken in front of the house in Boston, in upstate New York outside of Buffalo, where in 1939 they set up their private medical practice. After WWII, they built a new house next door.

Henny Molling nee Meyerhof, Therese Gottschalk nee Molling, Kurt, Elizabeth and Hal Gottschalk on the beach; Norderney, Germany.

Sitting in the Strandkorb (beach chair) at Norderney are Henny Molling and Therese Gottschalk; sitting in the sand are Kurt, Elizabeth and Hal Gottschalk

Elizabeth Krakauer nee Gottschalk in an unknown early Krakauer apartment.

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Studio portrait of Elizabeth Krakauer nee Gottschalk; Hannover, Germany.

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Therese Godshaw (Gottschalk) nee Molling reading with her daughter Elizabeth; Hannover, Germany.

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Wedding portrait of Hans Krakauer and Elizabeth Gottschalk; Hannover, Germany. Portraits Couples

In the apartment on Ruemkorffstrasse that the Gottschalks occupied after being forced to sell their house.