Los discursos sobre el final del terrorismo de ETA en el País Vasco. Aplicación de los modelos de Entman y Cohen al análisis de prensa escrita entre 2011 y 2014

521 p.

ISOEMBRAPA: perpectivas na busca pela excelência na gestão da Embrapa.

2008

Estratégia de implementação do protocolo de hipertensão arterial/risco cardiovascular - SMSA 2009, pela Equipe Azul do centro de saúde Marcelo Pontel Gomes

Este estudo tem como objetivo implementar a sistematização do atendimento ao hipertenso de acordo com as diretrizes propostas pelo Protocolo de Hipertensão Arterial/Risco cardiovascular - SMSA 2009. Foi realizada uma revisão de literatura nacional para avaliar as contribuições dos estudos produzidos, com relação à sistematização e controle do acompanhamento de pacientes hipertensos para subsidiar a proposta de implantação do protocolo de hipertensão arterial. A HAS é uma doença crônica, na maioria das vezes assintomática e constitui um dos principais fatores de risco para o aparecimento das doenças cardíacas. Seu controle é geralmente insatisfatório. Dentre os principais fatores que determinam um controle muito baixo da HAS está a baixa adesão ao tratamento por parte dos pacientes que ocorre freqüentemente quando as ações são executadas por um único profissional de saúde, tradicionalmente o médico. A equipe multidisciplinar e o tratamento sistematizado propiciarão uma abordagem mais ampla com muitas informações importantes ao hipertenso e a comunidade, ajudando-os na incorporação hábitos saudáveis e atitudes efetivas e definitivas para o controle da hipertensão.

Plano de intervenção para análise do comportamento do Diabetes mellitus na Unidade Básica de Saúde Marcelo Pontel Gomes, município Belo Horizonte, Minas Gerais

A comunidade de Jardim Vitoria está localizada na região nordeste de Belo Horizonte. Seu centro de saúde Marcelo Pontel Gomes fica próximo à saída para Vitória Espírito Santo, sendo seu principal problema de saúde o Diabetes Melitus (DM). O objetivo do trabalho é propor um plano de intervenção para diminuir a incidência de Diabetes Melitus e seus fatores de risco. O estudo foi realizado no ano 2014 na cidade de Belo Horizonte, Minas Gerais, com enfoque na população da área de abrangência da Unidade Básica de Saúde (UBS) Marcelo Pontel Gomes, localizada no bairro Jardin Vitoria. No desenvolvimento desse projeto serão utilizados trabalhos científicos disponíveis em base de dados como: Biblioteca Virtual em Saúde, Biblioteca Virtual da Universidade Federal de Minas Gerais, bem como publicações em livros e revistas médicas serão selecionados conforme sua relevância. Outros dados importantes que serão utilizados são os disponíveis na Secretaria Municipal de Saúde de Belo Horizonte, dados do Ministério da Saúde e arquivos da própria UBS Marcelo Pontel Gomes. Serão utilizados no trabalho descritores tais como: Atenção Primária à Saúde, Diabetes Melitus, Sistema Único de Saúde, Fatores de risco. O trabalho vai contar com a participação dos profissionais de saúde e população da área de abrangência da Unidade Básica de Saúde do bairro Jardim Vitória. O DM é uma doença da qual a pessoa deve ter conhecimento para evitar complicações. A carência assistencial da saúde e/ou uso incorreto das medicações pelo usuário, aumenta a possibilidade de gravidade da doença através de diferentes manifestações clínicas.

Abordagem e tratamento do tabagismo na área de abrangência do centro de saúde Marcelo Pontel Gomes, Belo Horizonte, Minas Gerais

O tabagismo constitui uma das causas dominantes de morte evitável no mundo e seus malefícios à saúde não se restringem aos seus usuários diretos, causando danos aos chamados fumantes passivos. Diante disso, propõe-se um projeto de intervenção em uma unidade de saúde, com o objetivo reduzir o número de pessoas tabagistas no território sob responsabilidade da Equipe Azul do Centro de Saúde Marcelo Pontel Gomes. Este Trabalho de conclusão de curso é requisito para obtenção do título de especialista em Estratégia de Saúde da Família, parte integrante do Projeto Mais Médico para o Brasil.Ao longo do segundo semestre e através das etapas realizadas nos módulos de Iniciação à Metodologia: Textos Científicos e Planejamento e Avaliação em Saúde, foi possível chegar-se à construção dessa etapa do trabalho. Diante dos problemas identificados no diagnóstico situacional, com apoio da população e dos profissionais da equipe, espera-se com a implantação do projeto, reduzir o número de fumantes na população atendida.

Melhoria da Atenção aos Usuários com Hipertensão Arterial Sistêmica e/ou Diabetes Mellitus, na UBS Dr. Marcelo Cândia, Macapá/AP

MARRERO, Dania Cisnero. Melhoria da atenção aos usuários com Hipertensão Arterial Sistêmica e/ou Diabetes Mellitus, na UBS Dr. Marcelo Cândia, Macapá/Amapá. 2015. 88f. Trabalho de Conclusão de Curso (Curso de Especialização em Saúde da Família) - Departamento de Medicina Social, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, 2015. Considerando a elevada morbimortalidade por Diabete Mellitus (DM) e Hipertensão Arterial Sistêmica (HAS) presente na área de abrangência da unidade, a prevenção destas doenças e das suas complicações, foi o tema selecionado para realizar a intervenção com o objetivo de melhorar atenção à saúde dos usuários hipertensos e diabéticos e contribuir para melhorar sua qualidade de vida, promovendo o cadastramento dos usuários na população adstrita, mediante ações de assistência, promoção e prevenção. Este trabalho foi feito na Unidade Básica de Saúde Dr “Marcelo Cândia” do Município de Macapá, Estado Amapá, no período compreendido de 12 de março até 28 de maio de 2015. O levantamento dos dados foi possível pelo monitoramento constante dos dados dos usuários, com o rigoroso preenchimento das fichas espelhos, prontuários e planilha de coleta de dados. No transcurso da intervenção foi possível cadastrar 332 usuários hipertensos e 98 diabéticos, para um total de 34,7 % e 35,5% de cobertura respectivamente. O exame clínico apropriado foi realizado em 96,4% dos hipertensos em 98,0% dos diabéticos, os exames complementares foram realizados em 94,9% e 98% de hipertensos e diabéticos respectivamente, a prescrição de medicamentos da farmácia popular teve uma proporção de 94% nos hipertensos e 93,8% dos diabéticos. A avaliação de necessidade de atendimento odontológico foi realizada em 84,3% dos hipertensos e em 93,9% dos diabéticos, só três hipertensos não tiveram estratificação do risco cardiovascular, enquanto que 100% dos diabéticos foram avaliados e também 100% dos usuários participantes da intervenção receberam ações de promoção em saúde com orientações sobre alimentação saudável, prática de atividade física regular, riscos do tabagismo e importância da higiene bucal. Foram muito significativos os resultados alcançados na organização da equipe, que pela primeira vez, faz um trabalho adequado na comunidade para melhorar os atendimentos destes usuários com doenças crônicas não transmissíveis. Conclui-se que o trabalho feito já foi incorporado à rotina do serviço, com a certeza de que tem se melhorado o estado de saúde dos usuários hipertensos e diabéticos da área de abrangência e daqui para frente vai ser estendida às demais ações programáticas segundo os protocolos estabelecidos pelo Ministério de Saúde.

Hemorrhagic Shock Secondary To Button Battery Ingestion.

Button battery ingestion is a frequent pediatric complaint. The serious complications resulting from accidental ingestion have increased significantly over the last two decades due to easy access to gadgets and electronic toys. Over recent years, the increasing use of lithium batteries of diameter 20 mm has brought new challenges, because these are more detrimental to the mucosa, compared with other types, with high morbidity and mortality. The clinical complaints, which are often nonspecific, may lead to delayed diagnosis, thereby increasing the risk of severe complications. A five-year-old boy who had been complaining of abdominal pain for ten days, was brought to the emergency service with a clinical condition of hematemesis that started two hours earlier. On admission, he presented pallor, tachycardia and hypotension. A plain abdominal x-ray produced an image suggestive of a button battery. Digestive endoscopy showed a deep ulcerated lesion in the esophagus without active bleeding. After this procedure, the patient presented profuse hematemesis and severe hypotension, followed by cardiorespiratory arrest, which was reversed. He then underwent emergency exploratory laparotomy and presented a new episode of cardiorespiratory arrest, which he did not survive. The battery was removed through rectal exploration. This case describes a fatal evolution of button battery ingestion with late diagnosis and severe associated injury of the digestive mucosa. A high level of clinical suspicion is essential for preventing this evolution. Preventive strategies are required, as well as health education, with warnings to parents, caregivers and healthcare professionals.

Antiangiogenic And Finasteride Therapies: Responses Of The Prostate Microenvironment In Elderly Mice.

The aim of this study was to evaluate the structural and molecular effects of antiangiogenic therapies and finasteride on the ventral prostate of senile mice. 90 male FVB mice were divided into: Young (18 weeks old) and senile (52 weeks old) groups; finasteride group: finasteride (20mg/kg); SU5416 group: SU5416 (6 mg/kg); TNP-470 group: TNP-470 (15 mg/kg,) and SU5416+TNP-470 group: similar to the SU5416 and TNP-470 groups. After 21 days, prostate ventral lobes were collected for morphological, immunohistochemical and Western blotting analyses. The results demonstrated atrophy, occasional proliferative lesions and inflammatory cells in the prostate during senescence, which were interrupted and/or blocked by treatment with antiangiogenic drugs and finasteride. Decreased AR and endostatin reactivities, and an increase for ER-α, ER-β and VEGF, were seen in the senile group. Decreased VEGF and ER-α reactivities and increased ER-β reactivity were verified in the finasteride, SU5416 groups and especially in SU5416+TNP-470 group. The TNP-470 group showed reduced AR and ER-β protein levels. The senescence favored the occurrence of structural and/or molecular alterations suggesting the onset of malignant lesions, due to the imbalance in the signaling between the epithelium and stroma. The SU5416+TNP-470 treatment was more effective in maintaining the structural, hormonal and angiogenic factor balance in the prostate during senescence, highlighting the signaling of antiproliferation via ER-β.

Mechanisms Predisposing Penile Fracture And Long-term Outcomes On Erectile And Voiding Functions.

Purpose. To determine the mechanisms predisposing penile fracture as well as the rate of long-term penile deformity and erectile and voiding functions. Methods. All fractures were repaired on an emergency basis via subcoronal incision and absorbable suture with simultaneous repair of eventual urethral lesion. Patients' status before fracture and voiding and erectile functions at long term were assessed by periodic follow-up and phone call. Detailed history included cause, symptoms, and single-question self-report of erectile and voiding functions. Results. Among the 44 suspicious cases, 42 (95.4%) were confirmed, mean age was 34.5 years (range: 18-60), mean follow-up 59.3 months (range 9-155). Half presented the classical triad of audible crack, detumescence, and pain. Heterosexual intercourse was the most common cause (28 patients, 66.7%), followed by penile manipulation (6 patients, 14.3%), and homosexual intercourse (4 patients, 9.5%). Woman on top was the most common heterosexual position (n = 14, 50%), followed by doggy style (n = 8, 28.6%). Four patients (9.5%) maintained the cause unclear. Six (14.3%) patients had urethral injury and two (4.8%) had erectile dysfunction, treated by penile prosthesis and PDE-5i. No patient showed urethral fistula, voiding deterioration, penile nodule/curve or pain. Conclusions. Woman on top was the potentially riskiest sexual position (50%). Immediate surgical treatment warrants long-term very low morbidity.

Endoscopic Endonasal Transsphenoidal Resection Of Pituitary Adenomas: Preliminary Evaluation Of Consecutive Cases.

Endoscopic endonasal transsphenoidal surgery has gained increasing acceptance by otolaryngologists and neurosurgeons. In many centers throughout the world, this technique is now routinely used for the same indications as conventional microsurgical technique for pituitary tumors. To present a surgical experience of consecutive endoscopic endonasal trans-sphenoidal resections of pituitary adenomas. In this study, consecutive patients with pituitary adenomas submitted to endoscopic endonasal pituitary surgery were evaluated regarding the rate of residual tumor, functional remission, symptoms relief, complications, and tumor size. Forty-seven consecutive patients were evaluated; 17 had functioning adenomas, seven had GH producing tumors, five had Cushing's disease, and five had prolactinomas. Of the functioning adenomas, 12 were macroadenomas and five were microadenomas; 30 cases were non-functioning macroadenomas. Of the patients with functioning adenomas, 87% improved. 85% of the patients with visual deficits related to optic nerve compression progressed over time. Most of the patients with complaints of headaches improved (76%). Surgical complications occurred in 10% of patients, which included with two carotid lesions, two cerebrospinal fluid leaks, and one death of a patient with a previous history of complications. Endoscopic endonasal pituitary surgery is a feasible technique, yielding good surgical and functional outcomes, and low morbidity.

Integrated Proteomics Identified Up-regulated Focal Adhesion-mediated Proteins In Human Squamous Cell Carcinoma In An Orthotopic Murine Model.

Understanding the molecular mechanisms of oral carcinogenesis will yield important advances in diagnostics, prognostics, effective treatment, and outcome of oral cancer. Hence, in this study we have investigated the proteomic and peptidomic profiles by combining an orthotopic murine model of oral squamous cell carcinoma (OSCC), mass spectrometry-based proteomics and biological network analysis. Our results indicated the up-regulation of proteins involved in actin cytoskeleton organization and cell-cell junction assembly events and their expression was validated in human OSCC tissues. In addition, the functional relevance of talin-1 in OSCC adhesion, migration and invasion was demonstrated. Taken together, this study identified specific processes deregulated in oral cancer and provided novel refined OSCC-targeting molecules.

Multiple Desmoid Tumors In A Patient With Gardner's Syndrome - Report Of A Case.

Desmoid tumor (DT) is a common manifestation of Gardner's Syndrome (GS), although it is a rare condition in the general population. DT in patients with GS is usually located in the abdominal wall and/or intra-abdominal cavity. We report a case of a 32 years-old female patient with familial adenomatous polyposis (FAP), who was already submitted to total colectomy and developed multiple DT, located in the abdominal wall and in the left breast. The patient underwent several surgical procedures, with a multidisciplinary team of surgeons. Wide surgical resections of the left breast and the abdominal wall tumors were performed in separate steps. Polypropylene mesh reconstruction and muscle flaps were needed to cover the defects of the thoracic and abdominal walls. After partial necrosis of the adipose-cutaneous flap in the abdomen that required a new skin graft, she had a satisfactory outcome with complete healing of the surgical incisions. DT is frequent in GS, however, breast localization is very rare, with few cases reported in the literature. Recurrence of DT is not negligible, even after a wide surgical resection. GS patients must be followed up closely, and clinical examination, associated with imaging studies, should be performed to detect any signs of tumor. DT represents one of the most significant causes of the morbidity and mortality that affects FAP patients following colectomy. In general, the surgical procedures to excise DT are highly complex, requiring a multidisciplinary team.

Profile Of The Use Of Disease Modifying Drugs In The Brazilian Registry Of Spondyloarthritides.

Few studies have evaluated the profile of use of disease modifying drugs (DMD) in Brazilian patients with spondyloarthritis (SpA). A common research protocol was applied prospectively in 1505 patients classified as SpA by criteria of the European Spondyloarthropathies Study Group (ESSG), followed at 29 referral centers in Rheumatology in Brazil. Demographic and clinical variables were obtained and evaluated, by analyzing their correlation with the use of DMDs methotrexate (MTX) and sulfasalazine (SSZ). At least one DMD was used by 73.6% of patients: MTX by 29.2% and SSZ by 21.7%, while 22.7% used both drugs. The use of MTX was significantly associated with peripheral involvement, and SSZ was associated with axial involvement, and the two drugs were more administered, separately or in combination, in the mixed involvement (p < 0.001). The use of a DMD was significantly associated with Caucasian ethnicity (MTX , p = 0.014), inflammatory back pain (SSZ, p = 0.002) , buttock pain (SSZ, p = 0.030), neck pain (MTX, p = 0.042), arthritis of the lower limbs (MTX, p < 0.001), arthritis of the upper limbs (MTX, p < 0.001), enthesitis (p = 0.007), dactylitis (MTX, p < 0.001), inflammatory bowel disease (SSZ, p < 0.001) and nail involvement (MTX, p < 0.001). The use of at least one DMD was reported by more than 70% of patients in a large cohort of Brazilian patients with SpA, with MTX use more associated with peripheral involvement and the use of SSZ more associated with axial involvement.

Identification Of Target Genes Using Gene Expression Profile Of Granulocytes From Patients With Chronic Myeloid Leukemia Treated With Tyrosine Kinase Inhibitors.

Differential gene expression analysis by suppression subtractive hybridization with correlation to the metabolic pathways involved in chronic myeloid leukemia (CML) may provide a new insight into the pathogenesis of CML. Among the overexpressed genes found in CML at diagnosis are SEPT5, RUNX1, MIER1, KPNA6 and FLT3, while PAN3, TOB1 and ITCH were decreased when compared to healthy volunteers. Some genes were identified and involved in CML for the first time, including TOB1, which showed a low expression in patients with CML during tyrosine kinase inhibitor treatment with no complete cytogenetic response. In agreement, reduced expression of TOB1 was also observed in resistant patients with CML compared to responsive patients. This might be related to the deregulation of apoptosis and the signaling pathway leading to resistance. Most of the identified genes were related to the regulation of nuclear factor κB (NF-κB), AKT, interferon and interleukin-4 (IL-4) in healthy cells. The results of this study combined with literature data show specific gene pathways that might be explored as markers to assess the evolution and prognosis of CML as well as identify new therapeutic targets.

S-nitrosoglutathione (gsno) Is Cytotoxic To Intracellular Amastigotes And Promotes Healing Of Topically Treated Leishmania Major Or Leishmania Braziliensis Skin Lesions-authors' Response.

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