Aún hay tiempo para desfacer el entuerto de la LOE : texto base de la Comparecencia en la Comisión de Educación del Congreso de los Diputados el 6 de octubre de 2005.

Se analiza la Ley Orgánica de Educación (LOE) a partir de la experiencia personal del profesor Julián Martín Martínez. Se destaca la marcha atrás en la legislación con esta ley y los mecanismos educativos, metodologías y didácticas. Se reflexiona y comparan las dos etapas de Secundaria: la obligatoria y la voluntaria. Por último, se proponen unas soluciones: grupos más pequeños y grupos homogéneos con más divisiones según la competencia académica y la actitud del alumno, por niveles de preparación; libertad organizativa del Centro para establecer grupos, desdobles dentro de un grupo, horas de clase en determinadas materias; que el trabajo-estudio sea decisivo para aprobar contando con la agrupación de los alumnos por niveles; en los pequeños grupos la atención se acompaña con refuerzos y recuperaciones; una prueba externa al finalizar la ESO que para el alumno sea como ganar algo permite subir la calidad y el nivel, motivaría al alumno y homologaría los centros; y la publicación de los resultados de los controles externos, necesaria para dinamizar el sistema.

Estado, ciudadanía y capital social: tres lecciones de paz en uno de los países más violentos de América Latina

El Salvador es uno de los países con más homicidios en América Latina desde hace más de cinco años. Un análisis comparativo de la tasas de homicidios de las naciones con más asesinatos en Latinoamérica reveló que, durante el 2005, en el territorio salvadoreño ocurrieron 54.7 homicidios por cada 100 mil habitantes. Para entonces Honduras, con problemas de delincuencia juvenil como la nación salvadoreña, tenía una tasa de 40.6 homicidios; mientras que Colombia, sumergido en un conflicto armado y con problemas de narcotráfico, alcanzó una tasa de 33.7 homicidios ese mismo año. Pese al panorama, no todo en El Salvador es así. Al analizar los homicidios por departamentos desde el 2002 hasta el 2007 se puede encontrar que existen alrededor de 21 municipios que no registran asesinatos. Tres de ellos llaman la atención en particular por su pasado violento al estar ubicados en sitios que fueron escenarios del conflictivo armado durante la guerra civil (1980–1992) y por la organización municipal que han alcanzado tras los Acuerdos de Paz entre la guerrilla y el gobierno salvadoreño en 1992.

Evaluation of Ir and Pd(NO3)(2)/Mg(NO3)(2) as Modifiers for the Simultaneous Determination of Mn, Ni, Pb, and Sb in Fuel Ethanol by Graphite Furnace MS

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A Simple Method Based on ICP-MS for Estimation of Background Levels of Arsenic, Cadmium, Copper, Manganese, Nickel, Lead, and Selenium in Blood of the Brazilian Population

Throughout the world, biomonitoring has become the standard for assessing exposure of individuals to toxic elements as well as for responding to serious environmental public health problems. However, extensive biomonitoring surveys require rapid and simple analytical methods. Thus, a simple and high-throughput method is proposed for the determination of arsenic (As), cadmium (Cd), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), and selenium (Se) in blood samples by using inductively coupled plasma-mass spectrometry (ICP-MS). Prior to analysis, 200 l of blood samples was mixed with 500 l of 10% v/v tetramethylammonium hydroxide (TMAH) solution, incubated for 10 min, and subsequently diluted to 10 ml with a solution containing 0.05% w/v ethylenediamine tetraacetic acid (EDTA) + 0.005% v/v Triton X-100. After that, samples were directly analyzed by ICP-MS (ELAN DRC II). Rhodium was selected as an internal standard with matrix-matching calibration. Method detection limits were 0.08, 0.04, 0.5, 0.09, 0.12, 0.04, and 0.1 g//L for As, Cd, Cu, Mn, Ni, Pb, and Se, respectively. Validation data are provided based on the analysis of blood samples from the trace elements inter-\comparison program operated by the Institut National de Sante Publique du Quebec, Canada. Additional validation was provided by the analysis of human blood samples by the proposed method and by using electrothermal atomic absorption spectrometry (ETAAS). The method was subsequently applied for the estimation of background metal blood values in the Brazilian population. In general, the mean concentrations of As, Cd, Cu, Mn, Ni, Pb, and Se in blood were 1.1, 0.4, 890, 9.6, 2.1, 65.4, and 89.3 g/L, respectively, and are in agreement with other global populations. Influences of age, gender, smoking habits, alcohol consumption, and geographical variation on the values were also considered. Smoking habits influenced the levels of Cd in blood. The levels of Cu, Mn, and Pb were significantly correlated with gender, whereas Cu and Pb were significantly correlated with age. There were also interesting differences in Mn and Se levels in the population living in the north of Brazil compared to the south.

Influência de materiais de cobertura e de alturas de cama, nos índices de conforto térmico e no desempenho de frangos de corte, em Dourados - MS

Pós-graduação em Agronomia (Energia na Agricultura) - FCA

Biodigestão anaeróbia e características de cama de frangos obtida sob diferentes quantidades iniciais de casca de arroz e três tipos de cobertura de galpões em Dourados - MS

Pós-graduação em Agronomia (Energia na Agricultura) - FCA

Análise energética na logística de transporte multimodal para exportação do etanol de Aparecida do Taboado (MS) até o porto de São Sebastião (SP)

Pós-graduação em Agronomia (Energia na Agricultura) - FCA

Arranjo espacial de plantas na cultura do pinhão manso em Selvíria (MS)

Pós-graduação em Agronomia - FEIS

Farmacocinética pré-clínica e avaliação toxicológica do novo composto α2-adrenérgico 3-(2-cloro-6-fluorobenzil)-imidazolidina-2,4-diona - PT-31 GIRSUPAN

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

LC-MS/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients

The chemotherapeutic drug 5-fluorouracil (5-FU) is widely used for treating solid tumors. Response to 5-FU treatment is variable with 10-30% of patients experiencing serious toxicity partly explained by reduced activity of dihydropyrimidine dehydrogenase (DPD). DPD converts endogenous uracil (U) into 5,6-dihydrouracil (UH(2) ), and analogously, 5-FU into 5-fluoro-5,6-dihydrouracil (5-FUH(2) ). Combined quantification of U and UH(2) with 5-FU and 5-FUH(2) may provide a pre-therapeutic assessment of DPD activity and further guide drug dosing during therapy. Here, we report the development of a liquid chromatography-tandem mass spectrometry assay for simultaneous quantification of U, UH(2) , 5-FU and 5-FUH(2) in human plasma. Samples were prepared by liquid-liquid extraction with 10:1 ethyl acetate-2-propanol (v/v). The evaporated samples were reconstituted in 0.1% formic acid and 10 μL aliquots were injected into the HPLC system. Analyte separation was achieved on an Atlantis dC(18) column with a mobile phase consisting of 1.0 mm ammonium acetate, 0.5 mm formic acid and 3.3% methanol. Positively ionized analytes were detected by multiple reaction monitoring. The analytical response was linear in the range 0.01-10 μm for U, 0.1-10 μm for UH(2) , 0.1-75 μm for 5-FU and 0.75-75 μm for 5-FUH(2) , covering the expected concentration ranges in plasma. The method was validated following the FDA guidelines and applied to clinical samples obtained from ten 5-FU-treated colorectal cancer patients. The present method merges the analysis of 5-FU pharmacokinetics and DPD activity into a single assay representing a valuable tool to improve the efficacy and safety of 5-FU-based chemotherapy.

Ms. hebr. oct. 162 - [Sammelband in 6 Teilen: Handschriftenkonvolut]

Vorbesitzer: Abraham Merzbacher