La aljama de juheus de Vich (centuries XIII y XIV)

per Ramon Corbella

Eine hebräische Grammatik aus dem XIII. Jh.

zum ersten Male hrsg., mit Einl. und Anm. vers. von Samuel Poznański

Hebräische Grabsteine aus dem XIII.-XV. Jahrhundert in Wien und Umgebung : vorgel. in der Sitzung am 1. Dez. 1915

von Bernhard Wachstein

Glossaire hébreu-francais du XIII. siècle : recueil de mots hébreux bibliques avec trad. francaise ; Ms. de la Bibliotheque Nationale, fonds hébreu, no. 302

publié sous les auspices de l'Académie des Inscriptions et Belles-Lettres par Mayer Lambert et Louis Brandin

Ms. Ff. Mus. 937 - Dominica XIII. post Trinitatis : Du solt lieben Gott deinen Herrn ; a canto, alto, tenore, basso, 2 violini, viola, 2 hautbois, violoncello, violono, bassono ed organo

di Telemann

The activation peptide of coagulation factor XIII is vital for its expression and stability.

BACKGROUND The human activation peptide of factor XIII (AP-FXIII) comprises the first 37 amino acids of the N-terminus and holds the FXIII in an inactive state. FXIII is activated either proteolytically by cleavage of AP-FXIII by thrombin, or non-proteolytically by high calcium concentrations. OBJECTIVE To investigate the role of AP-FXIII in the expression and stability of FXIII. METHODS We cloned 13 FXIII variants with progressive truncations of AP-FXIII from the N-terminus (delN-FXIII-A), expressed them in mammalian cells, and measured their thermostability, activation, and transglutaminase activity. We also used in silico calculations to analyze the stability of hypothetical delN-FXIII dimers and to identify crucial motifs within AP-FXIII. RESULTS Variants with deletions longer than the first 10 amino acids and an R11Q point mutant were not expressed as proteins. In silico calculations indicated that the sequence (8) FGGR(12) R plays a substantial role in intersubunit interactions in FXIII-A2 homodimers. In agreement with this prediction, the temperature stability of delN-FXIII variants decreased with increasing length of deletion. These results may suggest a role of the N-terminus of AP-FXIII in dimer stability. Substantial sequence homology was found among activation peptides of vertebrate and even invertebrate (crustacean) FXIII-A orthologs, which further supports our conclusion. CONCLUSIONS We conclude that deletion of 11 or more N-terminal amino acids disrupts intersubunit interactions, which may prevent FXIII-A2 homodimer formation. Therefore, AP-FXIII plays an important role in the stability of the FXIII-A2 dimer.

Rumänien und seine Juden : XIII.

S. Schiffer

Leo XIII. und die Juden

-r.

Das messianische Gastmahl der Gerechten in einer hebräischen Bibel aus dem XIII. Jahrhundert : Ein Beitrag zur eschatologischen Ikonographie bei den Juden

Zofia Ameisenowa

Aus einer süditalienischen Handschrift (XIII. Jh.) in der Stadtbibliothek Bern [Illustration]

Scan von Monochrom-Mikroform

Synagoge in Trani aus dem XIII. Jahrhundert [Illustration] : Süditalien

Scan von Monochrom-Mikroform