Tom e Vinícius na Alvorada: um prisma geográfico

This article has been generated by the interface between geography and music. Methodologically, we have used a multidisciplinary bibliography that contemplates cultural geography, history, music, linguistics, literature, anthropology, for we understand that, for the understanding of a polysemous code, as it is in music, we need a diversity of looks. Our main document for an analysis of the construction of Brasília is the “Sinfonia da Alvorada” (Symphony of the Dawn), composed by Antônio Carlos Jobim and Vinícius de Moraes. Here, we attempt mainly to do a textual analysis of the work under an external perspective of the symphonic work, we mean, analyzing more its semantics (considering the product between interlocution and interpretation), and less its instrumental aesthetics, although the latter is also present. Finally, we attempt to understand the connection that exists between the actors and the spaces which are metamorphosing along with the construction of the city and which puts into evidence the idea of social circularity, proposed by the “Sinfonia da Alvorada”. This piece captures social and cultural elements related to the construction of Brasília and repositions and rearranges it through the execution of the music, in such a way that this arrangement can provide a change in the senses which are constructed from the urban experience in Brasília.

Geografia das telecomunicações no Brasil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Nitric oxide modulates metalloproteinase-2, collagen deposition and adhesion rate after polypropylene mesh implantation in the intra-abdominal wall

Prosthetic meshes are commonly used to correct abdominal wall defects. However, the inflammatory reaction induced by these devices in the peritoneum is not completely understood. We hypothesized that nitric oxide (NO), produced by nitric oxide synthase 2 (NOS2) may modulate the response induced by mesh implants in the abdominal wall and, consequently, affect the outcome of the surgical procedure. Polypropylene meshes were implanted in the peritoneal side of the abdominal wall in wild-type and NOS2-deficient (NOS2(-/-)) mice. After 15 days tissues around the mesh implant were collected, and inflammatory markers (the cytokine interleukin 1 beta (IL-1 beta) and NO) and tissue remodeling (collagen and metalloproteinases (MMP) 2 and 9) were analyzed. The lack of NOS2-derived NO induced a higher incidence of visceral adhesions at the mesh implantation site compared with wild-type mice that underwent the same procedure (P < 0.05). Additionally, higher levels of IL-1 beta were present in the mesh-implanted NOS2(-/-) animals compared with control and wild-type mice. Mesh implantation induced collagen I and III deposition, but in smaller amounts in NOS2(-/-) mice. MMP-9 activity after the surgical procedure was similarly increased in both groups. Conversely, MMP-2 activity was unchanged in mesh-implanted wild-type mice, but was significantly increased in NOS2(-/-) mice (P < 0.01), due to decreased S-nitrosylation of the enzyme in these animals. We conclude that NOS2-derived NO is crucial for an adequate response to and integration of polypropylene mesh implants in the peritoneum. NO deficiency results in a prolonged inflammatory reaction to the mesh implant, and reduced collagen deposition may contribute to an increased incidence of visceral adhesions. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.