Newberry Hall

Cornerstone laid May 26, 1888; dedicated June 1891. Gift of Helen H. Newberry of Detroit as headquarters of Students' Christian Association. Leased by U-M as classroom in 1921; gift to U-M from SCA in 1937. Adapted as museum in 1928, named the Francis W. Kelsey Museum of Archaeology in 1953.

Newberry Hall

Cornerstone laid May 26, 1888; dedicated June 1891. Gift of Helen H. Newberry of Detroit as headquarters of Students' Christian Association. Leased by U-M as classroom in 1921; gift to U-M from SCA in 1937. Adapted as museum in 1928, named the Francis W. Kelsey Museum of Archaeology in 1953.

Newberry Hall Ann Arbor

Cornerstone laid May 26, 1888; dedicated June 1891. Gift of Helen H. Newberry of Detroit as headquarters of Students' Christian Association. Leased by U-M as classroom in 1921; gift to U-M from SCA in 1937. Adapted as museum in 1928, named the Francis W. Kelsey Museum of Archaeology in 1953.

Law

York and Sawyer, architects. Given to the university by William W. Cook, the four buildings comprising the Law Quadrangle with their construction dates are: the Lawyers Club, 1924; the John P. Cook Dormitory, 1930; the Legal Research Building, 1931, and Hutchins Hall, 1933. The Legal Research Building includes the original library.

Law School Bldgs

York and Sawyer, architects. Given to the university by William W. Cook, the four buildings comprising the Law Quadrangle with their construction dates are: the Lawyers Club, 1924; the John P. Cook Dormitory, 1930; the Legal Research Building, 1931, and Hutchins Hall, 1933. The Legal Research Building includes the original library. Image is torn and creased.

Law Quad

York and Sawyer, architects. Given to the university by William W. Cook, the four buildings comprising the Law Quadrangle with their construction dates are: the Lawyers Club, 1924; the John P. Cook Dormitory, 1930; the Legal Research Building, 1931, and Hutchins Hall, 1933. The Legal Research Building includes the original library.

Law Quad

York and Sawyer, architects. Given to the university by William W. Cook, the four buildings comprising the Law Quadrangle with their construction dates are: the Lawyers Club, 1924; the John P. Cook Dormitory, 1930; the Legal Research Building, 1931, and Hutchins Hall, 1933. The Legal Research Building includes the original library.

Law Quadrangle

York and Sawyer, architects. Given to the university by William W. Cook, the four buildings comprising the Law Quadrangle with their construction dates are: the Lawyers Club, 1924; the John P. Cook Dormitory, 1930; the Legal Research Building, 1931, and Hutchins Hall, 1933. The Legal Research Building includes the original library.

The Lawyer's Club and Dormitory

Given to the university by William W. Cook, the four buildings comprising the Law Quadrangle with their construction dates are: the Lawyers Club, 1924; the John P. Cook Dormitory, 1930; the Legal Research Building, 1931, and Hutchins Hall, 1933. Architects: York & Sawyer. The Legal Research Building includes the original library.

John Tidwell, UM Men's Basketball, 1961

[Ensian caption: "As Walt Bellamy moves in to assist his Indiana teammate, John Tidwell arches a shot over their outstretched arms.]

A practical and theoretical essay on oblique bridges.

Mode of access: Internet.

Engineering studies,

Mode of access: Internet.

Evidence for endothermic ancestors of crocodiles at the stem of archosaur evolution

Physiological, anatomical, and developmental features of the crocodilian heart support the paleontological evidence that the ancestors of living crocodilians were active and endothermic, but the lineage reverted to ectothermy when it invaded the aquatic, ambush predator niche. In endotherms, there is a functional nexus between high metabolic rates, high blood flow rates, and complete separation of high systemic blood pressure from low pulmonary blood pressure in a four-chambered heart. Ectotherms generally lack all of these characteristics, but crocodilians retain a four-chambered heart. However, crocodilians have a neurally controlled, pulmonary bypass shunt that is functional in diving. Shunting occurs outside of the heart and involves the left aortic arch that originates from the right ventricle, the foramen of Panizza between the left and right aortic arches, and the cog-tooth valve at the base of the pulmonary artery. Developmental studies show that all of these uniquely crocodilian features are secondarily derived, indicating a shift from the complete separation of blood flow of endotherms to the controlled shunting of ectotherms. We present other evidence for endothermy in stem archosaurs and suggest that some dinosaurs may have inherited the trait.

HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor

Hemopoietic cells, apparently committed to one lineage, can be reprogrammed to display the phenotype of another lineage. The J2E erythroleukemic cell line has on rare occasions developed the features of monocytic cells. Subtractive hybridization was used in an attempt to identify genes that were up-regulated during this erythroid to myeloid transition. We report here on the isolation of hemopoietic lineage switch 5 (Hls5), a gene expressed by the monocytoid variant cells, but not the parental J2E cells. Hls5 is a novel member of the RBCC (Ring finger, B box, coiled-coil) family of genes, which includes Pml, Herf1, Tif-1alpha, and Rfp. Hls5 was expressed in a wide range of adult tissues; however, at different stages during embryogenesis, Hls5 was detected in the branchial arches, spinal cord, dorsal root ganglia, limb buds, and brain. The protein was present in cytoplasmic granules and punctate nuclear bodies. Isolation of the human cDNA and genomic DNA revealed that the gene was located on chromosome 8p21, a region implicated in numerous leukemias and solid tumors. Enforced expression of Hls5 in HeLa cells inhibited cell growth, clonogenicity, and tumorigenicity. It is conceivable that HLS5 is one of the tumor suppressor genes thought to reside at the 8p21 locus.

Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP)

Cdca4 (Hepp) was originally identified as a gene expressed specifically in hematopoietic progenitor cells as opposed to hematopoietic stem cells. More recently, it has been shown to stimulate p53 activity and also lead to p53-independent growth inhibition when overexpressed. We independently isolated the murine Cdca4 gene in a genomic expression-based screen for genes involved in mammalian craniofacial development, and show that Cdca4 is expressed in a spatio-temporally restricted pattern during mouse embryogenesis. In addition to expression in the facial primordia including the pharyngeal arches, Cdca4 is expressed in the developing limb buds, brain, spinal cord, dorsal root ganglia, teeth, eye and hair follicles. Along with a small number of proteins from a range of species, the predicted CDCA4 protein contains a novel SERTA motif in addition to cyclin A-binding and PHD bromodomain-binding regions of homology. While the function of the SERTA domain is unknown, proteins containing this domain have previously been linked to cell cycle progression and chromatin remodelling. Using in silico database mining we have extended the number of evolutionarily conserved orthologues of known SERTA domain proteins and identified an uncharacterised member of the SERTA domain family, SERTAD4, with orthologues to date in human, mouse, rat, dog, cow, Tetraodon and chicken. Immunolocalisation of transiently and stably transfected epitope-tagged CDCA4 protein in mammalian cells suggests that it resides predominantly in the nucleus throughout all stages of the cell cycle. (c) 2006 Elsevier B.V. All rights reserved.