Apolipoprotein E and Alzheimer disease.

Inheritance of specific apolipoprotein E (apoE) alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic Alzheimer disease. The mechanism by which the apoE isoforms differentially contribute to disease expression is, however, unknown. Isoform-specific differences have been identified in the binding of apoE to the microtubule-associated protein tau, which forms the paired helical filament and neurofibrillary tangles, and to amyloid beta peptide, a major component of the neuritic plaque. These and other isoform-specific interactions of apoE give rise to testable hypotheses for the mechanism(s) of pathogenesis of Alzheimer disease. An unresolved issue of increasing importance is the relationship between the structural pathological lesions and the cellular pathogenesis responsible for the clinical disease phenotype, progressive dementia. The identification of apoE in the cytoplasm of human neurons and the characterization of isoform-specific binding of apoE to the microtubule-associated proteins tau and MAP-2 present the possibility that apoE may affect microtubule function in the Alzheimer brain.

Men and heart disease : an atlas of racial and ethnic disparities in mortality /

Includes bibliographical references and index.

The general guide to rare Americana, with auction records and prices; a hand book and guide to the rare and notable books relating to America. With chronological and regional inventories of early printed books in the United States, and a key to American imprints, 1639-1889.

Bibliography: p. 11-13.

On the diseases and derangements of the nervous system : in their primary forms and in their modifications by age, sex, constitution, hereditary predisposition, excesses, general disorder, and organic disease /

Mode of access: Internet.

Interesting narrative : being a journal of the flight of Alfred E. Mathews, of Stark Co., Ohio, from the State of Texas, on the 20th of April, and his arrival at Chicago on the 28th of May, after traversing on foot and alone a distance of over 800 miles across the States of Louisiana, Arkansas and Missouri, by the most unfrequented routes ...

"Civil War Centennial issue. Facsimile copy ... from the original in the Western History Department, Denver Public Library."

The international directory of second-hand booksellers and bibliophile's manual : including lists of the public libraries of the world; publishers, book collectors, learned societies and institutions, theological colleges burns clubs, &c.

Earlier editions pub. under title: The directory of second-hand booksellers and list of public libraries, British and foreign. Later editions pub. under title: The international directory of booksellers and bibliophile's manual.

The amateur's hand-book and guide to home or drawing room theatricals. How to get them up and how to act in them,

Mode of access: Internet.

A peculiar and unusual disease of the osseous tissue in the horse : resembling, in many of its characteristics, Mollities ossium, Rhachitis, Osteoporosis, and fatty degeneration of bone /

"Reprinted from the 'Veterinarian'."

The grouse in health and in disease, being the final report of the Committee of inquiry on grouse disease.

Mode of access: Internet.

Artistic horse-shoeing, a practical and scientific treatise, giving improved methods of shoeing, with special directions for shaping shoes to cure different diseases of the foot, and for the correction of faulty action in trotters.

Mode of access: Internet.

The repository of wit and humor; comprising more than one thousand anecdotes, odd scraps, off-hand hits, and humorous sketches;

Mode of access: Internet.

Campaign hand book and citizen's manual.

Mode of access: Internet.

The Illinois long-term care and chronic disease facilities plan : [rule 3B] / prepared by the Illinois Department of Public Health, Office of Health Facilities and Quality of Care ; approved and adopted by the Illinois Health Facilities Planning Board.

Effective July 21, 1977.

The Illinois long-term care and chronic disease facilities plan [Chapter 3B] /

"Approved and adopted by the Illinois Health Facilities Planning Board"--T.p.