Synergy between chronic corticosterone and sodium azide treatments in producing a spatial learning deficit and inhibiting cytochrome oxidase activity.

Previously, we developed a rat model of persistent mitochondrial dysfunction based upon the chronic partial inhibition of the mitochondrial enzyme cytochrome oxidase (EC 1.9.3.1). Continuous systemic infusion of sodium azide at approximately 1 mg/kg per hr inhibited cytochrome oxidase activity and produced a spatial learning deficit. In other laboratories, glucocorticoids have been reported to exacerbate neuronal damage from various acute metabolic insults. Therefore, we tested the hypothesis that corticosterone, the primary glucocorticoid in the rat, would potentiate the sodium azide-induced learning deficit. To this end, we first identified nonimpairing doses of sodium azide (approximately 0.75 mg/kg per hr) and corticosterone (100-mg pellet, 3-week sustained-release). We now report that chronic co-administration of these individually nonimpairing treatments produced a severe learning deficit. Moreover, the low dose of corticosterone, which did not elevate serum corticosterone, acted synergistically with sodium azide to inhibit cytochrome oxidase activity. The latter result represents a previously unidentified effect of glucocorticoids that provides a candidate mechanism for glucocorticoid potentiation of neurotoxicity induced by metabolic insult. These results may have the clinical implication of expanding the definition of hypercortisolism in patient populations with compromised oxidative metabolism. Furthermore, they suggest that glucocorticoid treatment may contribute to pathology in disease or trauma conditions that involve metabolic insult.

Multiple Perspectives on Academic Service-Learning Partnerships at the American University in Cairo: A Mixed Method Study

This mixed method study aimed to redress the gap in the literature on academic service-learning partnerships, especially in Eastern settings. It utilized Enos and Morton's (2003) theoretical framework to explore these partnerships at the American University in Cairo (AUC). Seventy-nine community partners, administrators, faculty members, and students from a diverse range of age, citizenship, racial, educational, and professional backgrounds participated in the study. Qualitative interviews were conducted with members of these four groups, and a survey with both close-ended and open-ended questions administered to students yielded 61 responses. Qualitative analyses revealed that the primary motivators for partners' engagement in service-learning partnerships included contributing to the community, enhancing students' learning and growth, and achieving the civic mission of the University. These partnerships were characterized by short-term relationships with partners' aspiring to progress toward long-term commitments. The challenges to these partnerships included issues pertaining to the institution, partnering organizations, culture, politics, pedagogy, students, and faculty members. Key strategies for improving these partnerships included institutionalizing service-learning in the University and cultivating an institutional culture supportive of community engagement. Quantitative analyses showed statistically significant relationships between students' scores on the Community Awareness and Interpersonal Effectiveness scales and their overall participation in community service activities inside and outside the classroom, as well as a statistically significant difference between their scores on the Community Awareness scale and department offering service-learning courses. The study's outcomes underscore the role of the local culture in shaping service-learning partnerships, as well as the role of both curricular and extracurricular activities in boosting students' awareness of their community and interpersonal effectiveness. Cultivating a culture of community engagement and building support mechanisms for engaged scholarship are among the critical steps required by public policy-makers in Egypt to promote service-learning in Egyptian higher education. Institutionalizing service-learning partnerships at AUC and enhancing the visibility of these partnerships on campus and in the community are essential to the future growth of these collaborations. Future studies should explore factors affecting community partners' satisfaction with these partnerships, top-down and bottom-up support to service-learning, the value of reflection to faculty members, and the influence of students' economic backgrounds on their involvement in service-learning partnerships.

The curricular value of mathematics in non-mathematics degree

Higher education should provide the acquisition of skills and abilities that allow the student to play a full and active role in society. The educational experience should offer a series of conceptual, procedural and attitudinal contents that encourage “learning to know, learning to do, learning to be and learning to live together”. It is important to consider the curricular value of mathematics in the education of university undergraduates who do not intend to study mathematics but for whom the discipline will serve as an instrumental. This work discusses factors that form part of the debate on the curricular value of mathematics in non-mathematics degrees.

Los MOOC. Un nuevo modelo de e-learning en el panorama educativo actual

La educación está enmarcada por las características de una sociedad actual en la que internet es el medio donde se están implementando nuevos enfoques dirigidos a la formación. Los MOOC, así, se están configurando como una nueva forma de e-learning en el contexto actual, especialmente en la enseñanza superior. En este trabajo abordamos este nuevo término para analizar, por un lado, su significado, características y principales plataformas virtuales que los ofrecen y, por otro lado, las cuestiones que deben resolverse con el fin de configurar un nuevo modelo de e-learning. Concluimos que este nuevo modelo debe ser acorde con una planificación de política educativa y análisis curricular.

Diseño curricular y elaboración de materiales para el programa de postgrado en tecnología de color utilizando la plataforma Moodle

En los últimos años, la investigación realizada por el grupo de Visión y Color nos ha permitido conocer la demanda existente en el mercado laboral de expertos en tecnología y reproducción del color, especialmente relacionado con los materiales gonio-aparentes, materiales que ofrecen atractivos atributos para el sector del automóvil, entre otros. Por esta razón, miembros del Grupo de Visión y Color de la Universidad de Alicante nos hemos involucrado en esta red cuyo objetivo principal es ofrecer un programa de postgrado para titulados y no titulados, con una amplia y completa formación en Tecnología de Color. En particular, esta red se ha centrado en el diseño curricular y la elaboración de materiales docentes para este programa de postgrado. En primer lugar, se han desarrollado las guías docentes de cada una de las asignaturas propuestas con el fin de planificar cada una de ellas y poder desarrollar los materiales docentes adecuados. Dado las características de este programa de postgrado, todos los materiales se han elaborado en la plataforma Moodle ya que permite el seguimiento por parte del alumno a distancia (b-learning).

How to deal with quasi-loss of nationality situations? Learning from promising practices. CEPS Liberty and Security in Europe No. 71/December 2014

This paper was prepared as a Policy Brief for discussion at the final conference of the project on Involuntary Loss of European Citizenship: Exchanging Knowledge and Identifying Guidelines for Europe, 11-12 December 2014. Co-funded by the European Commission’s DG for Justice, Citizenship and Fundamental Rights, the ILEC project has aimed to establish a framework for debate on international norms on involuntary loss of nationality. For more information visit: www.ilecproject.eu.

The complete dictionary of arts and sciences. In which the whole circle of human learning is explained, and the difficulties attending the acquisition of every art, whether liberal or mechanical, are removed, in the most easy and familiar manner ... /

Mode of access: Internet.

The complete dictionary of arts and sciences. In which the whole circle of human learning is explained, and the difficulties attending the acquisition of every art, whether liberal or mechanical, are removed, in the most easy and familiar manner ... /

Mode of access: Internet.

The complete dictionary of arts and sciences. In which the whole circle of human learning is explained, and the difficulties attending the acquisition of every art, whether liberal or mechanical, are removed, in the most easy and familiar manner ... /

Mode of access: Internet.

Substance of lectures on the ancient Greeks, and on the revival of Greek learning in Europe.

Preface signed: John Dalzel.

A Tamil hand-book : or Full introduction to the common dialect of that language on the plan of Ollenndorf and Arnold, for the use of foreigners learning Tamil, and of Tamilians learning English; with copious vocabularies (Tamil-English, and English-Tamil,) appendices containing reading lessons, analyses of letters, deeds, complaints, official documents.

7th ed. published under title: A handbook of the Tamil language.

Learning to fly : a practical manual for beginners /

Book-plates of Aero club of America.

A practical method of learning to speak correctly the Castilian language.

Mode of access: Internet.

A manual of chemistry on the basis of Dr. Turner's Elements of chemistry : containing in a condensed form all the most important facts and principles of the science : designed for a text book in colleges and other seminaries of learning /

Mode of access: Internet.