Castellum Huttonicum. : Some account of Sheriff-Hutton Castle, (founded in the reign of King Stephen) with brief notices of the Church of St. Helen, the ancient forest of Galtres, the poet Gower of Stitenham, &c. &c. With two litographic views and a plan of the castle, and an engraving of the Princess Elizabeth of York, afterwards Queen of Henry VII.

Advertisements: [4] p. at end.

Marysieńka Marie de la Grange D'Arquien, queen of Poland, and wife of Sobieski. 1641-1716,

"List of authorities consulted": p. [xiii]-xvi.

The life of Sir Anthony Panizzi, K.C.B., late principal librarian of the British Museum, senator of Italy /

Mode of access: Internet.

The life and correspondence of Sir Anthony Panizzi, k.c. b., late principal librarian of the British museum, senator of Italy, etc. In two volumes.

The proposed third volume was never published, although copyright claim is printed on back of t.-p. ("The Reminiscences copyright 1881 by Henry Stevens of Vermont." The records of the Copyright office do not bear out this statement) The material was later published in Transactions and proceedings of the Library association of the United Kingdom at their seventh annual meeting...1884. London, 1890 (p. 117-124: Twenty years reminiscences of Panizzi and the British museum, 1845-1865)

Menticulture; or, The A-B-C of true living,

Emancipation.

A B C of Queensland statistics.

19 comp. by Thornhill Weedon ... government statistician, Queensland. By direction of the Honourable the home secretary.

Evaluation of the chapter 30 program for the Department of Veterans Affairs : final report.

"Contract no. V101(93)P-1203; Task order no. 2."

The life of Sir George Pomeroy--Colley, K. C. S. I., C. B., C. M. G., 1835-1881;

Mode of access: Internet.

L.M.B.C. memoirs on typical British marine plants and animals.

Imprint varies. No. 24-34 published: Liverpool : Liverpool University Press.

The English, Scotch and Irish historical libraries. Giving a short view and character of most of our historians, either in print or manuscript. With an account of our records, lawbooks, coins, &c. by W. Nicolson, late bishop of Carlisle. To which is added, A letter to the Reverend White Kennet, D. D., in defence of the English historical library, &c.

The letter to Kennett is a reply to Francis Atterbury.

Transmitting components of Radio Set SCR-197-C, Radio Set SCR-197-D and Radio Set SCR-197-F.

"June 8, 1942."

Sources and transport of surface sediment and metals in B.C. fjord, Tahsis and Zeballos Inlets

Senior thesis written for Oceanography 445

Prospective evaluation of a D-optimal designed population pharmacokinetic study

Recently, methods for computing D-optimal designs for population pharmacokinetic studies have become available. However there are few publications that have prospectively evaluated the benefits of D-optimality in population or single-subject settings. This study compared a population optimal design with an empirical design for estimating the base pharmacokinetic model for enoxaparin in a stratified randomized setting. The population pharmacokinetic D-optimal design for enoxaparin was estimated using the PFIM function (MATLAB version 6.0.0.88). The optimal design was based on a one-compartment model with lognormal between subject variability and proportional residual variability and consisted of a single design with three sampling windows (0-30 min, 1.5-5 hr and 11 - 12 hr post-dose) for all patients. The empirical design consisted of three sample time windows per patient from a total of nine windows that collectively represented the entire dose interval. Each patient was assigned to have one blood sample taken from three different windows. Windows for blood sampling times were also provided for the optimal design. Ninety six patients were recruited into the study who were currently receiving enoxaparin therapy. Patients were randomly assigned to either the optimal or empirical sampling design, stratified for body mass index. The exact times of blood samples and doses were recorded. Analysis was undertaken using NONMEM (version 5). The empirical design supported a one compartment linear model with additive residual error, while the optimal design supported a two compartment linear model with additive residual error as did the model derived from the full data set. A posterior predictive check was performed where the models arising from the empirical and optimal designs were used to predict into the full data set. This revealed the optimal'' design derived model was superior to the empirical design model in terms of precision and was similar to the model developed from the full dataset. This study suggests optimal design techniques may be useful, even when the optimized design was based on a model that was misspecified in terms of the structural and statistical models and when the implementation of the optimal designed study deviated from the nominal design.

NMR imaging of the diffusion of water at 37 degrees C into poly(2-hydroxyethyl methacrylate) containing aspirin or vitamin B-12

The ingress of water into poly(2-hydroxyethyl methacrylate), PHEMA, loaded with either one of two model drugs, vitamin B-12 or aspirin, was studied at 37 degreesC using three-dimensional NMR imaging. PHEMA was loaded with 5 and 10 wt % of the drugs. From the imaging profiles, it was observed that incorporation of vitamin B-12 into PHEMA resulted in enhanced crack formation on sorption of water and the crack healing behind the diffusion front was slower than for PHEMA without added drug. This was accounted for by the anti-plasticization of PHEMA by vitamin B-12. Crack formation was inhibited in the P-HEMA-aspirin systems because of the plasticizing effect of the aspirin on the PHEMA matrix. All of the polymers were found to absorb water according to an underlying Fickian diffusion mechanism. For PHEMA loaded with 5 wt % of aspirin or vitamin B-12, the best values of the water diffusion coefficients were both found to be 1.3 +/- 0.1 x 10(-11) m(2) s(-1) at 37 degreesC, while the values for the polymer loaded with 10 wt % of the drugs were slightly higher, 1.5 +/- 0.1 x 10(-11) m(2) s(-1).