A significant effect of the KIR ligand HLA-C on fibrosis progression in chronic C hepatitis with or without liver transplantation.

BACKGROUND & AIMS The interaction of KIR with their HLA ligands drives the activation and inhibition of natural killer (NK) cells. NK cells could be implicated in the development of liver fibrosis in chronic hepatitis C. METHODS We analysed 206 non-transplanted and 53 liver transplanted patients, selected according to their Metavir fibrosis stage. Several variables such as the number of activator KIR or the HLA ligands were considered in multinomial and logistic regression models. Possible confounding variables were also investigated. RESULTS The KIRs were not significant predictors of the fibrosis stage. Conversely, a significant reduction of the HLA-C1C2 genotype was observed in the most advanced fibrosis stage group (F4) in both cohorts. Furthermore, the progression rate of fibrosis was almost 10 times faster in the subgroup of patients after liver transplantation and HLA-C1C2 was significantly reduced in this cohort compared to non-transplanted patients. CONCLUSION This study suggests a possible role of KIR and their ligands in the development of liver damage. The absence of C1 and C2 ligands heterozygosity could lead to less inhibition of NK cells and a quicker progression to a high level of fibrosis in patients infected by HCV, especially following liver transplantation. This article is protected by copyright. All rights reserved.

Ms. Ff. Mus. 1119 - Am XI post Trinit. : Herr! sey mir gnädig, denn mir ist angst pp. ; C. A. T. B., 2 violini, 2 oboe se piace, 1 viola, violoncello et organo

von Telemann. [Textdichter: Gottfried Simonis]

[Vier-Tages-Schlacht 1666] : [mit Porträtmedaillons von] Michiel Adriaensz De Ruyter L. Admiral von Holland, Ct. ; Ad. C . Tromp

Aus: [Relationis historicae semestralis continuatio ; 1666, Herbst]

C. Dumont, Brustbild

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C. von Weisbrod, Brustbild

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Alfredo C. Piatti, Brustbild

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C. Wilhelmi, Brustbild

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"The girl in the taxi.", Mr. C. H. Workman as "Pomarel" and Miss Yvonne Arnaud as "Suzanne"

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Beethovens Geburtszimmer im Beethovenhaus zu Bonn, ganz im alten Zustande erhalten. Die in diesem geweihten Raume stehende Marmorbüste von Prof. C. Voss ist alleiniges Eigenthum des Beethovenhauses und nicht im Handel.

Signatur des Originals: S 36/F02872

Aus dem Museum-Zimmer des 2. Stockwerks im Beethoven-Hause in Bonn: Original-Modell zu dem Beethoven-Denkmal in Wien (auf dem Beethoven-Platz an der Wiener Ringstrasse) von Prof. C. von Zumbusch. Geschenk des Künstlers an das Beethovenhaus in Bonn

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C. Hayden Coffin, Rollenbild, Kniestück, in: La Cigale

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C. Hayden Coffin, Rollenbild, Brustbild, in: La Cigale

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Nina C. F. Kennedy, Rollenbild, Brustbild

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Alfredo C. Piatti, Brustbild

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C. F. W. Schmidt, Brustbild, Profil

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