Sharḥ al-asmāʼ al-ḥusná : manuscript, undated

Written in several hands, in one or two columns, from 21 to 26 lines per pages, in black rubricated in red. Folios 6v-13r framed within double black lines.

Intraperitoneal bevacizumab for control of malignant ascites due to advanced-stage gastrointestinal cancers: A multicentre double-blind, placebo-controlled phase II study - AIO SUP-0108

PURPOSE: Malignant ascites is debilitating for patients with advanced cancer. As shown previously, tumour cell production of vascular endothelial growth factor might be a major cause of the formation of malignant ascites. Intraperitoneal bevacizumab could therefore be an option for symptom control in refractory ascites. PATIENTS AND METHODS: Patients with advanced gastrointestinal cancer and malignant ascites who had undergone paracentesis at least twice within the past 4 weeks were randomly assigned in a 2:1 ratio to intraperitoneal bevacizumab (400 mg absolute) or placebo after paracentesis. During the 8-week treatment period, a minimum interval of 14 d was kept between the applications of the study drug. Primary end-point was paracentesis-free survival (ParFS). RESULTS: Fifty-three patients (median age 63 years) were randomised. Forty-nine patients received at least one study drug application and qualified for the main analysis. The proportion of patients with at least one common toxicity criteria grade III-V event was similar with 20/33 (61%) on bevacizumab and 11/16 (69%) on placebo. Median ParFS was 14 d (95% confidence interval [CI]: 11-17) in the bevacizumab arm and 10.5 d (95% CI: 7-21) on placebo (hazard ratio 0.74, 95% CI: 0.40-1.37; P = 0.16). The longest paracentesis-free period was 19 d on bevacizumab (range 6-66 d) and 17.5 d in the placebo arm (range 4-42) (P = 0.85). Median overall survival was 64 d (95% CI: 45-103) on bevacizumab compared to 31.5 d (95% CI: 20-117) on placebo (P = 0.31). CONCLUSION: Intraperitoneal bevacizumab was well tolerated. Overall, treatment did not result in a significantly better symptom control of malignant ascites. However, patients defined by specific immune characteristics may benefit.

Symphonien

Bd. 1. No. 1, D dur [K.504] No. 2, G moll [K.550] No. 3, Es dur [K.543] No. 4, C dur [K.551] No. 5, D dur [K.385] No. 6, C dur [K.425]--Bd. 2. No. 7, D dur [Serenade, K.320] No. 8, D dur [Serenade, K.248b (250)] No. 9, D dur [K.300a (297) No. 10, C dur [K.338] No. 11, B dur [K.319] No. 12, G dur [K.Anh.293]

Ierokleous philosophou Ypomnema eis ta ton Pythagoreion epe ta chrysa = Hieroclis philosophi commentarius in aurea Pythagoreorum carmina /

Mode of access: Internet.

Reports of cases determined in the Appeal and Chancery divisions and selected cases in the King's Bench and at Chambers of the Supreme Court of New Brunswick,

Vol. 1, p. 1-158, was first published from Chipman's manuscript by John C. Allen in 1849. Vol. 2 issued originally in parts.

Volupté.

On cover: 5. éd. rev et corr. 1867.

Saemmtiliche Werke... /

Cada tomo con portada y paginación propia.

Œuvres de Jean Racine, avec des commentaires,

"Commentaire ... fait en société avec Blin de Sainmore."--Brunet, Manuel du libraire. 5. éd.

Nouveaux lundis,

Vol. 1:5. éd. rev.; v.3 7-8: 4.éd., rev.; v.5, 9; nouéd., rev.;v.10; 3.ed., rev.

Politiques et moralistes du dix-neuvième siècle ...

1. sér. Joseph de Maistre. de Bonald. Madame de Staël. Benjamin Constant. Royer-Collard. Guiget. 5 éd., 1899 -- 2. sér. Saint-Simon, Fourier. Lamennais. Ballanche. Edgar Quinet. Fictor Cousin. Auguste Comte. 1898 -- 3. sér. Stendhal. Tocqueville. Proudhon. Sainte-Beuve. H. Taine. E. Renan. 1900.

Histoire ancienne de l'église ...

t.1, 2, 5 éd., 1911 t.3, 3 éd., 1910.

Napoléon et Alexandre Ier. L'alliance russe sous le premier empire ...

--I. De Tilsit à Erfurt. 4. éd. 1896.--II. 1809. Le second mariage de Napoléon; déclin de l'alliance. 2. éd. 1893.--III. La rupture. 5. éd. 1908.

Enrichment of nitrifying microbial communities from shrimp farms and commercial inocula

Nitrifying bacteria were selected from shrimp farm water and sediment (natural seed) in Thailand and from commercial seed cultures. The microbial consortia from each source giving the best ammonia removal during batch culture pre-enrichments were used as inocula for two sequencing batch reactors (SBRs). Nitrifiers were cultivated in the SBRs with 100 mg NH4-N/I and artificial wastewater containing 25 ppt salinity. The two SBRs were operated at a 7 d hydraulic retention time (HRT) for 77 d after which the HRT was reduced to 3.5 d. The amounts of ammonia removed from the influent by microorganisms sourced from the natural seed were 85% and 92% for the 7 d HIRT and the 3.5 d HRT, respectively. The ammonia removals of microbial consortia from the commercial seed were 71% and 83% for these HRTs respectively. The quantity of ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB) was determined in the SBRs using the most probable number (MPN) technique. Both AOB and NOB increased in number over the long-term operation of both SBRs. According to quantitative fluorescence in situ hybridisation (FISH) probing, AOB from the natural seed and commercial seed comprised 21 +/- 2% and 30 +/- 2%, respectively of all bacteria. NOB could not be detected with currently-reported FISH probes, suggesting that novel NOB were enriched from both sources. Taken collectively, the results from this study provide an indication that the nitrifiers from shrimp farm sources are more effective at ammonia removal than those from commercial seed cultures.

Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection

This article investigates the expression patterns of 160 genes that are expressed during early mouse development. The cDNAs were isolated from 7.5 d postcoitum (dpc) encloderm, a region that comprises visceral encloderm (VE), definitive encloderm, and the node-tissues that are required for the initial steps of axial specification and tissue patterning in the mouse. To avoid examining the same gene more than once, and to exclude potentially ubiquitously expressed housekeeping genes, cDNA sequence was derived from 1978 clones of the Endoderm library. These yielded 1440 distinct cDNAs, of which 123 proved to be novel in the mouse. In situ hybridization analysis was carried out on 160 of the cDNAs, and of these, 29 (18%) proved to have restricted expression patterns.