Filón de Alejandría : Obra y pensamiento. Una lectura filológica

Filón de Alejandría (30?a. C.-50? d. C.) es una figura clave para conocer la profunda relación entre Judaísmo y Helenismo en el siglo I d. C. Judío practicante, su profundo dominio de la lengua, la literatura y, de modo especial, la retórica griegas lo convierten en una personalidad extraordinaria de su tiempo, tanto por su exégesis de la Torá (o Pentateuco) como por sus escritos apologéticos, históricos y filosóficos. Su testimonio es de gran valor para todo estudioso de la Antigüedad clásica por los muchos datos que aporta acerca de la filosofía, el pensamiento, la educación y la tradición clásica en el momento histórico que le tocó vivir, precisamente en un centro cultural de excepcional importancia dentro del Imperio romano

La vejez en la Atenas clásica vista a través de epigramas funerarios

Los epigramas son pequeñas composiciones en verso grabadas inicialmente sobre algún objeto, bien con fines votivos, como fórmulas de maldición, o simplemente como marcas de propiedad. Dentro de los epigramas destacan los funerarios, consistentes, en su origen, en versos inscritos sobre las tumbas, que indicaban filiación, edad y alguna característica del difunto, pero que más tarde se convirtieron en verdaderas composiciones literarias, por lo que resultan testimonios útiles para conocer a la sociedad griega. En esta ponencia se analizará la concepción griega de la vejez a través de los epigramas funerarios áticos de la época clásica (siglos V y IV a. C.). Este análisis se hará comparando lo inscrito en éstos con lo que algunos autores clásicos dijeron acerca de ese tema (ya sea con o sin intención). El objetivo es conocer más de esta cultura y demostrar cómo el imaginario social se reflejó en estos testimonios funerarios

Preconditioning in the reef-building coral Pocillopora damicornis and the potential for trans-generational acclimatization in coral larvae under future climate change conditions

Coral reefs are globally threatened by climate change-related ocean warming and ocean acidification (OA). To date, slow-response mechanisms such as genetic adaptation have been considered the major determinant of coral reef persistence, with little consideration of rapid-response acclimatization mechanisms. These rapid mechanisms such as parental effects that can contribute to trans-generational acclimatization (e.g. epigenetics) have, however, been identified as important contributors to offspring response in other systems. We present the first evidence of parental effects in a cross-generational exposure to temperature and OA in reef-building corals. Here, we exposed adults to high (28.9°C, 805 µatm PCO2) or ambient (26.5°C, 417 µatm PCO2) temperature and OA treatments during the larval brooding period. Exposure to high treatment negatively affected adult performance, but their larvae exhibited size differences and metabolic acclimation when subsequently re-exposed, unlike larvae from parents exposed to ambient conditions. Understanding the innate capacity corals possess to respond to current and future climatic conditions is essential to reef protection and maintenance. Our results identify that parental effects may have an important role through (1) ameliorating the effects of stress through preconditioning and adaptive plasticity, and/or (2) amplifying the negative parental response through latent effects on future life stages. Whether the consequences of parental effects and the potential for trans-generational acclimatization are beneficial or maladaptive, our work identifies a critical need to expand currently proposed climate change outcomes for corals to further assess rapid response mechanisms that include non-genetic inheritance through parental contributions and classical epigenetic mechanisms.

Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes

The influenza A virus pandemic of 1918–1919 resulted in an estimated 20–40 million deaths worldwide. The hemagglutinin and neuraminidase sequences of the 1918 virus were previously determined. We here report the sequence of the A/Brevig Mission/1/18 (H1N1) virus nonstructural (NS) segment encoding two proteins, NS1 and nuclear export protein. Phylogenetically, these genes appear to be close to the common ancestor of subsequent human and classical swine strain NS genes. Recently, the influenza A virus NS1 protein was shown to be a type I IFN antagonist that plays an important role in viral pathogenesis. By using the recently developed technique of generating influenza A viruses entirely from cloned cDNAs, the hypothesis that the 1918 virus NS1 gene played a role in virulence was tested in a mouse model. In a BSL3+ laboratory, viruses were generated that possessed either the 1918 NS1 gene alone or the entire 1918 NS segment in a background of influenza A/WSN/33 (H1N1), a mouse-adapted virus derived from a human influenza strain first isolated in 1933. These 1918 NS viruses replicated well in tissue culture but were attenuated in mice as compared with the isogenic control viruses. This attenuation in mice may be related to the human origin of the 1918 NS1 gene. These results suggest that interaction of the NS1 protein with host-cell factors plays a significant role in viral pathogenesis.

Real time optimization in chemical process: evaluation of strategies, improvements and industrial application.

The increasing economic competition drives the industry to implement tools that improve their processes efficiencies. The process automation is one of these tools, and the Real Time Optimization (RTO) is an automation methodology that considers economic aspects to update the process control in accordance with market prices and disturbances. Basically, RTO uses a steady-state phenomenological model to predict the process behavior, and then, optimizes an economic objective function subject to this model. Although largely implemented in industry, there is not a general agreement about the benefits of implementing RTO due to some limitations discussed in the present work: structural plant/model mismatch, identifiability issues and low frequency of set points update. Some alternative RTO approaches have been proposed in literature to handle the problem of structural plant/model mismatch. However, there is not a sensible comparison evaluating the scope and limitations of these RTO approaches under different aspects. For this reason, the classical two-step method is compared to more recently derivative-based methods (Modifier Adaptation, Integrated System Optimization and Parameter estimation, and Sufficient Conditions of Feasibility and Optimality) using a Monte Carlo methodology. The results of this comparison show that the classical RTO method is consistent, providing a model flexible enough to represent the process topology, a parameter estimation method appropriate to handle measurement noise characteristics and a method to improve the sample information quality. At each iteration, the RTO methodology updates some key parameter of the model, where it is possible to observe identifiability issues caused by lack of measurements and measurement noise, resulting in bad prediction ability. Therefore, four different parameter estimation approaches (Rotational Discrimination, Automatic Selection and Parameter estimation, Reparametrization via Differential Geometry and classical nonlinear Least Square) are evaluated with respect to their prediction accuracy, robustness and speed. The results show that the Rotational Discrimination method is the most suitable to be implemented in a RTO framework, since it requires less a priori information, it is simple to be implemented and avoid the overfitting caused by the Least Square method. The third RTO drawback discussed in the present thesis is the low frequency of set points update, this problem increases the period in which the process operates at suboptimum conditions. An alternative to handle this problem is proposed in this thesis, by integrating the classic RTO and Self-Optimizing control (SOC) using a new Model Predictive Control strategy. The new approach demonstrates that it is possible to reduce the problem of low frequency of set points updates, improving the economic performance. Finally, the practical aspects of the RTO implementation are carried out in an industrial case study, a Vapor Recompression Distillation (VRD) process located in Paulínea refinery from Petrobras. The conclusions of this study suggest that the model parameters are successfully estimated by the Rotational Discrimination method; the RTO is able to improve the process profit in about 3%, equivalent to 2 million dollars per year; and the integration of SOC and RTO may be an interesting control alternative for the VRD process.

The emergence of classical behaviour in magnetic adatoms

A wide class of nanomagnets shows striking quantum behaviour, known as quantum spin tunnelling (QST): instead of two degenerate ground states with opposite magnetizations, a bonding-antibonding pair forms, resulting in a splitting of the ground-state doublet with wave functions linear combination of two classically opposite magnetic states, leading to the quenching of their magnetic moment. Here we study how QST is destroyed and classical behaviour emerges in the case of magnetic adatoms, where, contrary to larger nanomagnets, the QST splitting is in some instances bigger than temperature and broadening. We analyze two different mechanisms for the renormalization of the QST splitting: Heisenberg exchange between different atoms, and Kondo exchange interaction with the substrate electrons. Sufficiently strong spin-substrate and spin-spin coupling renormalize the QST splitting to zero allowing the environmental decoherence to eliminate superpositions between classical states, leading to the emergence of spontaneous magnetization. Importantly, we extract the strength of the Kondo exchange for various experiments on individual adatoms and construct a phase diagram for the classical to quantum transition.

Themes and reviews, 1788-1805

Small notebook with brown paper covers containing handwritten entries noting the essay topics given to students between 1788 and 1805 according to class. The prompts are in both English and Latin and are generally philosophical quotations or verse from poetry that students responded to in short essays. There is a small handwritten chart for "A Scheme for a Lottery for a New College" laid into the back of the volume.

Declaration signed by Harvard students to not speak in the vernacular for one year, 1712 August 23

The declaration, handwritten in Latin and signed by members of the junior and sophomore classes (Harvard Classes of 1714 and 1715), promises that the undersigned will not use the vernacular but instead "whenever, at meals, at banquets,...in our rooms, in all our gatherings, wherever and whenever" will speak in Latin, Greek, or Hebrew through the next May. Additional Latin text appears on both the front and back of the document. The original is accompanied by a typed transcription and two partial handwritten translations. Note at top of original: "Script. Leonardo Dowding, Composit. a Tho. Foxcroft."

Letter of recommendation for Amos Main from Joseph Moodey to Nathan Prince, 1725 July 2

Handwritten letter sent by Joseph Moody, schoolmaster in York, to Harvard Tutor Nathan Prince recommending student Amos Main for acceptance to the College. In the letter, Moody requests Prince give Main an examination for admission, with the caveat that though Main has been studying Latin and Greek he has a difficult home life and is "somewhat Raw; yet I hope you'l wink at it." The letter, dated July 2, 1725, is written on a folded folio-sized leaf; there are handwritten notes about Massachusetts towns on the verso.

Commonplace book of John Holyoke, 1662 - May 1663

This unbound commonplace book was kept by John Holyoke during 1662 and 1663. The volume contains chiefly religious quotations and sermon notes (possibly of sermons preached by Holyoke himself), in English, Latin and Greek. Both ends of the volume were used to begin writing: the front page reads “Johannes Holyoke, adjunctu occupatu, May-1663” and the rear page reads “Johannes Holyoke [illegible] 1662.” The texts do not follow a straight tête-bêche model, where one text is upside down in relation to the other; rather, the texts change direction several times within the volume. The volume also includes part of letter sent to Holyoke’s grandfather Pynchon, September 16, 16?? [date illegible], as well as a series of alphabetically arranged quotations.

Student notebook of Marston Cabot, ca. 1720-1735

This leather-bound volume contains excerpts copied by Marston Cabot from books he read while he was a student at Harvard in 1723. The volume includes extracts from Charles Morton's 1687 Compendium Physicae (titled "of Phisicks" by Cabot), Dr. Adriani Heereboord (Adrianus Heereboord), Philosophia Naturalis and Johanne-Henrico Alstedio’s (John Henry Alsted) geometry text Compendium Geometria. The excerpts from Compendium Geometria include both figures and text, primarily in Latin with some Greek. The volume also includes “Theses quaedam extractae potissimum ex Enchiridio Metaphysico Domini Johannis Clerici" a précis of Jean Le Clerc's Ontologia et Pneumatologia made by Jonathan Remington, a Harvard Tutor from 1703 to 1711, to serve in place of printed textbooks. The names Jonathan Jackson and Edward Jackson are written on the inside cover, suggesting the book may have been handed down to Edward Jackson (Class of 1726) and his son Jonathan Jackson (Class of 1761). The text of the volume is in Marston Cabot's hand.

New England and Middle Atlantic States, ca. 1684 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Novi Belgii Novaeque Angliae nec non partis Virginiae tabula : multis in locis emendata, per Nicolaum Visscher. It was published by N. Visscher ca. 1684. Scale [ca. 1:2,250,000]. Covers the northeast Atlantic States from Maine to Virginia, and a portion of Canada. In Latin and Dutch. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Mercator (world) projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as human settlements, forts, Native American tribal lands, drainage, territorial boundaries, shoreline features, and more. Relief is shown pictorially. Includes decorative cartouche and inset view of Manhattan: Nieuw Amsterdam op t eylant Manhattans. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Estats de l'Empire du grand Seigneur des Turcs en Europe, en Asie, et en Afrique divisé en tous ses Beglerbeglicz ou Gouvernements; où sont aussi remarqués les Estats qui luy sont tributaires: dressé sur les plus nouvelles relations à l'usage de Monseigneur le Duc de Bourgogne

par son très humble et très obéisant Serviteur H. Iaillot.

Fabulae aesōpicae collectae /

Preface in Latin. Text in Greek.

The Odes and Epodes,

Latin and English on opposite pages.