Aula matemàtica, 2a. part. : un projecte per a la millora de l'aprenentatge de les matemàtiques a la UAB

El projecte Aula Matemàtica consta de dues parts. 1. Elaborar un material d'autoaprenentatge en suport digital que cobreixi tots els temes de Matemàtiques de 1r. curs de les carreres de Ciències (Biologia, Química, etc.) i les Enginyeries. Aquest material, accessible des de qualsevol ordinador connectat a Internet, és una base de dades de problemes que els alumnes poden utilitzar per a treballar el temes explicats a classe, o be per cobrir deficiències a la seva formació pre-universitària. Al mateix temps, es poden realitzar exàmens, i els alumnes poden practicar amb els problemes d'examen. 2. Durant unes hores cada dia, oferir una (o diverses) aules d'informàtica al campus de la UAB amb presència de personal de suport (professors, o becaris de darrers cursos de matemàtiques o doctorat) per tal que els alumnes que vulguin (o necessitin) puguin practicar amb ajuda, i consultat els dubtes que tinguin. En la fase actual del projecte s’han fet les següents actuacions: 1. S’ha obert una aula d’informàtica amb suport de becaris a la facultat de Ciències, on a més de practicar els alumnes, s’han efectuat exàmens. 2. S’ha treballat en el programa per tal de fer-lo més amigable. 3. S’ha ampliat la base de problemes fins a 1450, i cobrir totes les assignatures de Matemàtiques i Estadística de 1r. curs de la facultat de Ciències i l’Escola Tècnica Superior d’Enginyeries. 4. S’ha començat a treballar per a la utilització del programa a Secundària. 5. S’han fet avanços molt importants per tal d’incorporar problemes amb resposta oberta. 6. El programa és accessible des de qualsevol ordenador amb Internet.

Limb-girdle Muscular Dystrophy Type 2A Can Result from Accelerated Autoproteolytic Inactivation of Calpain 3.

Loss-of-function mutations in calpain 3 have been shown to cause limb-girdle muscular dystrophy type 2A (LGMD2A), an autosomal recessive disorder that results in gradual wasting of the muscles of the hip and shoulder areas. Due to the inherent instability of calpain 3, recombinant expression of the full-length enzyme has not been possible, making in vitro analysis of specific LGMD2A-causing mutations difficult. However, because calpain 3 is highly similar in amino acid sequence to calpain 2, the recently solved crystal structure of full-length, Ca2+-bound, calpastatin-inhibited rat calpain 2 has allowed us to model calpain 3 as a Ca2+-bound homodimer. The model revealed three distinct areas of the enzyme that undergo a large conformational change upon Ca2+-binding. Located in these areas are several residues that undergo mutation to cause LGMD2A. We investigated the in vitro effects of six of these mutations by making the corresponding mutations in rat calpain 2. All six mutations examined in this study resulted in a decrease in enzyme activity. All but one of the mutations caused an increased rate of autoproteolytic degradation of the enzyme as witnessed by SDS-PAGE, indicating the decrease in enzyme activity is caused, at least in part, by an increase in the rate of autoproteolytic degradation. The putative in vivo effects of these mutations on calpain 3 activity are discussed with respect to their ability to cause LGMD2A.

Regional Advisory Committee on Cancer Third Report - November 2004 (PDF 166 KB)

The Regional Advisory Committee on Cancer (RACC) was established in 1997 to carry forward the recommendations of the 1996 Campbell Report and to provide advice to the Department of Health, Social Services and Public Safety on the future development of cancer services. (Appendix 1) The 27 members of RACC come from the Health and Social Services Councils (which represent the interests of the public), Trusts, Boards, primary care and the Department. Members are listed in Appendix 2 RACC held its first meeting in June 1997 and has continued to meet twice a year since then. The Northern Ireland Cancer Forum was established in 1999 and is a subgroup of RACC. It was recommended that a Forum should be developed to provide meeting point for all voluntary and statutory bodies dealing with cancer in Northern Ireland. The Forum has now met on seven occasions and continues to work well with a unity of purpose. åÊ åÊ

Evaluation of MRSA-Screen, a simple anti-PBP 2a slide latex agglutination kit, for rapid detection of methicillin resistance in Staphylococcus aureus.

The MRSA-Screen test (Denka Seiken Co., Ltd., Tokyo, Japan), consisting of a slide latex agglutination kit that detects PBP 2a with a monoclonal antibody, was blindly compared to the oxacillin disk diffusion test, the oxacillin-salt agar screen, and PCR of the mecA gene for the detection of methicillin resistance in Staphylococcus aureus. A total of 120 methicillin-susceptible S. aureus (MSSA) and 80 methicillin-resistant S. aureus (MRSA) isolates, defined by the absence or presence of the mecA gene, respectively, were tested. The MRSA-Screen test, the oxacillin disk diffusion test, and the oxacillin-salt agar screening test showed sensitivities of 100, 61.3, and 82.5% and specificities of 99.2, 96.7, and 98.3%, respectively. We conclude that the MRSA-Screen is a very accurate, reliable, and fast test (15 min) for differentiation of MRSA from MSSA colonies on agar plates.

Trasplante hepático: proceso asistencial integrado. 2ª ed

Publicado en la página web de la Consejería de Salud: www.juntadeandalucia.es/salud (Consejería de Salud / Profesionales / Nuestro Compromiso por la Calidad / Procesos Asistenciales Integrados)

Enfermedad pulmonar obstructiva crónica: proceso asistencial integrado. 2ª ed

En noviembre de 2015, se ha publicado la 3ª edición de este proceso (http://hdl.handle.net/10668/2125). Existe una guía de información para pacientes "Conozca cómo vivir mejor con la EPOC" basada en la 2ª edición de este Proceso.