Audit report on the Iowa College Student Aid Commission for the year ended June 30, 2013

Audit report on the Iowa College Student Aid Commission for the year ended June 30, 2013

Audit report on the Iowa Department on Aging for the year ended June 30, 2013

Audit report on the Iowa Department on Aging for the year ended June 30, 2013

Audit report on the Department of Management for the year ended June 30, 2013

Audit report on the Department of Management for the year ended June 30, 2013

Audit report on the Iowa Petroleum Underground Storage Tank Board for the year ended June 30, 2013

Audit report on the Iowa Petroleum Underground Storage Tank Board for the year ended June 30, 2013

Audit report on the Iowa Department of Human Services – Targeted Case Management Unit for the year ended June 30, 2013

Audit report on the Iowa Department of Human Services – Targeted Case Management Unit for the year ended June 30, 2013

CD8beta knockout mice mount normal anti-viral CD8+ T cell responses--but why?

It has been shown previously that CD8beta in vitro increases the range and the sensitivity of antigen recognition and in vivo plays an important role in the thymic selection of CD8+ T cells. Consistent with this, we report here that CD8+ T cells from CD8beta knockout (KO) P14 TCR transgenic mice proliferate inefficiently in vitro. In contrast to these findings, we also show that CD8beta KO mice mount normal CD8 primary, secondary and memory responses to acute infection with lymphocytic choriomeningitis virus. Tetramer staining and cytotoxic experiments revealed a predominance of CD8-independent CTL in CD8beta KO mice. The TCR repertoire, especially the one of the TCRalpha chain, was different in CD8beta KO mice as compared with B6 mice. Our results indicate that in the absence of CD8beta, CD8-independent TCRs are preferentially selected, which in vivo effectively compensates for the reduced co-receptor function of CD8alphaalpha.

Report on a review of State employee grievance processes, settlement agreements entered into by the State and payments made during the period July 1, 2010 through June 30, 2014

Report on a review of State employee grievance processes, settlement agreements entered into by the State and payments made during the period July 1, 2010 through June 30, 2014

Report on the Iowa Department of Human Services for the year ended June 30, 2013

Report on the Iowa Department of Human Services for the year ended June 30, 2013

Audit report on the Iowa Department of Justice for the year ended June 30, 2013

Audit report on the Iowa Department of Justice for the year ended June 30, 2013

Audit report on the Iowa State Civil Rights Commission for the year ended June 30, 2013

Audit report on the Iowa State Civil Rights Commission for the year ended June 30, 2013

Audit report on the Iowa Law Enforcement Academy for the year ended June 30, 2013

Audit report on the Iowa Law Enforcement Academy for the year ended June 30, 2013

Audit report on the Public Employment Relations Board for the year ended June 30, 2013

Audit report on the Public Employment Relations Board for the year ended June 30, 2013

Audit report on the Iowa Department of Public Safety for the year ended June 30, 2013

Audit report on the Iowa Department of Public Safety for the year ended June 30, 2013

Audit report on the National Deaf-Blind Equipment Distribution Program administered by the Iowa Utilities Board Division of the Iowa Department of Commerce for the year ended June 30, 2013

Audit report on the National Deaf-Blind Equipment Distribution Program administered by the Iowa Utilities Board Division of the Iowa Department of Commerce for the year ended June 30, 2013

Report on the six divisions of the Iowa Department of Commerce for the year ended June 30, 2013

Report on the six divisions of the Iowa Department of Commerce for the year ended June 30, 2013