Fragments d'un Coran.

Al-Qur'ān

Absence of BK viremia clearance after low-dose cidofovir therapy in kidney transplant recipients with BK virus associated nephropathy

Background: BK virus associated nephropathy occurs in 1-10% of kidney transplant recipients and may be a cause of graft loss. This infection is difficult to manage because of the absence of specific therapy. Cidofovir, a DNA polymerase inhibitor approved for the treatment of CMV retinitis, has shown in vitro activity against BK virus and some clinical efficacy when used at low-dose in uncontrolled series. Objective: To assess the efficacy of low-dose Cidofovir in the treatment of BK virus associated nephropathy. Method: Two adult kidney transplant recipients with biopsy-proven BK nephropathy and persistent high viremia (>10,000 copies/ml) despite 3-month reduction of immunosuppressive therapy were treated by Cidofovir 0.5 mg/kg fortnightly for a total of 16 weeks (8 doses). Clinical response was assessed by following BK viremia. Results: No decrease in BK viremia was observed at any point during cidofovir therapy (see figure). Creatinine clearance remained stable during therapy and no side-effects of Cidofovir were observed. Conclusions: Low-dose Cidofovir therapy was not associated with a clearance or with a significant decrease of BK viremia. This pilot study does not confirm previous reports suggesting clinical efficacy of Cidofovir for BK virus associated nephropathy.

1.° Rollandini, legum Doctoris, tractatus de ultimis voluntatibus. — 2.° Ordo judiciarius in foro ecclesiastico : authore Aegidio de Fuscariis, Doctore Bononiensi. — 3.° Ciceronis de natura deorum libri tres : primi libri initium desideratur. — 4.° Ejusdem orationes in Verrem : nonnulla passim desiderantur. — 5.° Apuleii de habitudine et doctrina Platonis fragmenta

Colbertinus

chartularium Episcopi Parisiensis.

Puteanus

Titi Livii historiae Romanae decas tertia.

Colbertinus

1.° Gesta Regum Francorum à Trojana gentis origine ad mortem Pipini, patris Caroli Magni : authore anonymo ; edita sunt ab Andrea Duchesne tomo 1. pag. 691. sed in hoc nostro codice auctiora et in multis discrepantia : praemittuntur canones synodi Romanae, ab Innocentio Papa II. congregatae anno 1138. — 2.° Vita Caroli Magni, Francorum Regis et Imperatoris, ibidem edita tom. 2. pag. 68. — 3.° Vita et conversatio Caroli Magni : authore Eginardo. — 4.° Vita Ludovici Pii, Imperatoris : incerto authore ; edita ab Andrea Duchesne tomo 2. pag. 286. — 5.° Fragmentum chronici de gestis Francorum, à Ludovico Pio ad annum 1029. authore Ademaro, Monacho S. Eparchii Engolismensis.

Faurianus

M. T. Ciceronis orationes in Verrem tertia, quarta et quinta : initium tertiae desideratur.

Puteanus

1.° P. Ovidii Nasonis heroïdes : epistolae octo priores integrae et nonae initium desiderantur. — 2.° Ejusdem amorum libri tres. — 3.° Ejusdem de arte amandi libri tres. — 4.° Ejusdem de remedio amoris libri duo. — 5.° Ejusdem carmen in ibin. — 6.° Ejusdem elegia de nuce. — 7.° Ejusdem carmen de medicamine faciei. — 8.° Ejusdem somnium. — 9.° Bernardi Silvestri megacosmus et microcosmus.

Mentellianus

Cartulaire de la commanderie des Templiers de Roaiz (Roaix, dioc. de Vaison).

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