The psychosis high-risk state: a comprehensive state-of-the-art review

Context During the past 2 decades, a major transition in the clinical characterization of psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for psychosis has evolved to capture the prepsychotic phase, describing people presenting with potentially prodromal symptoms. The importance of this HR state has been increasingly recognized to such an extent that a new syndrome is being considered as a diagnostic category in the DSM-5. Objective To reframe the HR state in a comprehensive state-of-the-art review on the progress that has been made while also recognizing the challenges that remain. Data Sources Available HR research of the past 20 years from PubMed, books, meetings, abstracts, and international conferences. Study Selection and Data Extraction Critical review of HR studies addressing historical development, inclusion criteria, epidemiologic research, transition criteria, outcomes, clinical and functional characteristics, neurocognition, neuroimaging, predictors of psychosis development, treatment trials, socioeconomic aspects, nosography, and future challenges in the field. Data Synthesis Relevant articles retrieved in the literature search were discussed by a large group of leading worldwide experts in the field. The core results are presented after consensus and are summarized in illustrative tables and figures. Conclusions The relatively new field of HR research in psychosis is exciting. It has the potential to shed light on the development of major psychotic disorders and to alter their course. It also provides a rationale for service provision to those in need of help who could not previously access it and the possibility of changing trajectories for those with vulnerability to psychotic illnesses.

Transactions of the Medical Society of the State of New York.

Lists of members in each volume; some of these are merely partial lists, members in attendance at the annual meetings, etc.

Proceedings of the ... annual meeting of the Virginia state bar association.

List of members in each volume; cumulative necrological list, in volumes for 1896- ; obituaries of members in volumes for 1891, 1893, 1895-

Proceedings of the ... Annual Meeting of the State Historical Society of Wisconsin.

Vols. published -1947 have title: Proceedings.

The Quarterly journal of the New York State Historical Association.

Also reissued by publisher in annual hard-cover ed. with vol. title pages.

Proceedings of the annual meeting of the New Jersey State Horticultural Society.

The meetings of 1877-1922 are numbered 2d-48th, after which the numbering was discontinued.

Annual report of the Wisconsin State Horticultural Society.

Includes proceedings of the Society's meetings.

[Minutes of meetings, Ithaca, N.Y., 1941: May 22, May 29]

Mimeographed.

[Minutes of meetings, Ithaca, N.Y., 1939: Mar. 13; Apr. 22; June 12; Aug. 9; Dec. 1, 15]

Mimeographed.

[Minutes of meetings, Ithaca, N.Y., 1940: Mar. 20-21; June 17-18; Sept. 26-28]

Mimeographed.

Proceedings of the ... annual meeting of the Oklahoma State Bar Association.

List of members in each volume.

Proceedings of the ... annual meeting of the Alabama State Bar Association.

Imprint varies.

Proceedings of the ... annual meeting of the Indiana State Bar Association.

Vols. for 1949-1956 published: Bloomington, Ind. : Indiana University School of Law.

School meetings /

Description based on: 1936; title from cover.

Proceedings of the ... annual meeting of the New York State Bar Association.

Annual meetings contain reports from previous year.