Content Management in Ruby on Rails

Web development is currently driven by model-view-controller (MVC) frameworks. How has content management adapted to this scenario? This paper reviews content management features in Ruby on Rails framework and its most popular plug-ins. These features are distributed among the different layers of the MVC architecture

A fusion pore phenotype in mast cells of the ruby-eye mouse

Using patch-clamp capacitance and amperometric techniques, we have identified an exocytotic phenotype that affects the function of the fusion pore, the molecular structure that connects the lumen of a secretory vesicle with the extracellular environment during exocytosis. Direct observation of individual exocytotic events in mast cells from the ruby-eye mouse (ru/ru) showed a 3-fold increase in the fraction and duration of transient fusion events with respect to wild-type mice. The fraction of the total fusion events that were transient increased from 0.22 ± 0.02 (wild type) to 0.65 ± 0.02 (ru/ru), and the average duration of these events increased from 418 ± 32 ms (wild type) to 1207 ± 89 ms (ru/ru). We also show that this phenotype can reduce and delay an evoked secretory response by causing the fusion of vesicles that have been previously emptied by repeated cycles of transient fusion. The exocytotic phenotype that we describe here may be a cause of diseases like platelet storage pool deficiency and prolonged bleeding times for which the ruby-eye mouse serves as an animal model. Furthermore, the identification of the gene causing the fusion pore phenotype reported here will illuminate the molecular mechanisms regulating exocytotic fusion.

Ruby's husband /

Mode of access: Internet.

Reconnaissance for radioactive deposits in the Ruby-Poorman and Nixon Fork districts, west-central Alaska, 1949,

Mode of access: Internet.

The ruby of Kishmoor,

Mode of access: Internet.

The Paternoster ruby.

Mode of access: Internet.

Eonchs of ruby. A gift of love.

Microfilm. Ann Arbor, Mich., University Microfilms [n.d.] (American culture series, Reel 333.7).

Rita Mae Brown, author of "Ruby fruit Jungle"

General note: Title and date provided by Bettye Lane.