Direct and general support maintenance repair parts and special tools list (including depot maintenance repair parts and special tools) : loader, scoop type, pneu-tired, diesel engine driven, hinged frame steer with 2 1/2 cubic yard multi-purpose bucket, (Allis-Chalmers model 645M), FSN 3805-051-9359.

Includes index.

Operator and organizational maintenance manual : loader, scoop type, pneu-tired, diesel engine driven, hinged frame steer with 2 1/2 cu yd multi-purpose bucket, Allis-Chalmers model 645M, FSN 3805-051-9359.

"July 1968."

Operator, organizational, direct support, and general support maintenance manual : loader, scoop type, DED, 4 wheel drive, pneumatic tired, hinged frame steer, 2 1/2 cu. yd. multi-purpose bucket (J.I. Case model MW-24), FSN 3805-253-0627.

"December 1970."

Organizational maintenance repair parts and special tools list : loader, scoop type, pneu-tired, diesel engine driven, hinged frame steer, with 2 1/2 cubic yard multi-purpose bucket (Allis-Chalmers model 645M) FSN 3805-051-9359.

"August 1974."

Direct and general support and depot maintenance manual : loader scoop type, pneu tired, diesel engine driven, hinged frame steer, with 2-1/2 cu yd multi-purpose bucket, Allis Chalmers model 645M, FSN 3805-051-9359.

Includes index.

Operator and organizational maintenance manual : loader, scoop type, DED, 4 wheel drive, pneumatic tired, hinged frame steer, 2 1/2 cu. yd. multi-purpose bucket (J.I. Case model MW-24B), FSN 3805-169-4711.

"October 1973."

Operator and organizational maintenance manual : loader, scoop type, pneu-tired, diesel engine driven, hinged frame steer with 2 1/2 cu yd multi-purpose bucket, Allis-Chalmers model 645M, FSN 3805-051-9359.

"July 1968."

Direct and general support and depot maintenance manual : generator set, diesel engine, 200 kw, 60 cycle, AC, 120/208 V, 240/416 V, 3 phase, convertible to 167 kw, 50 cycle, 120/208 V, 240/416 V, 3 phase, multi-purpose, portable, skid mounted (military design model SF-200-MD/CIED) ...

"February 1968."

eHabitat, a multi-purpose Web Processing Service for ecological modeling

The number of interoperable research infrastructures has increased significantly with the growing awareness of the efforts made by the Global Earth Observation System of Systems (GEOSS). One of the Societal Benefit Areas (SBA) that is benefiting most from GEOSS is biodiversity, given the costs of monitoring the environment and managing complex information, from space observations to species records including their genetic characteristics. But GEOSS goes beyond simple data sharing to encourage the publishing and combination of models, an approach which can ease the handling of complex multi-disciplinary questions. It is the purpose of this paper to illustrate these concepts by presenting eHabitat, a basic Web Processing Service (WPS) for computing the likelihood of finding ecosystems with equal properties to those specified by a user. When chained with other services providing data on climate change, eHabitat can be used for ecological forecasting and becomes a useful tool for decision-makers assessing different strategies when selecting new areas to protect. eHabitat can use virtually any kind of thematic data that can be considered as useful when defining ecosystems and their future persistence under different climatic or development scenarios. The paper will present the architecture and illustrate the concepts through case studies which forecast the impact of climate change on protected areas or on the ecological niche of an African bird.

CORE: A Multi-Purpose Programming Contest Repository System

Яни Чаушев, Милослав Средков, Красимир Манев - Всяко състезание по програмиране използва множество софтуерни инструменти за управление на процесите по време на състезанието. Въпреки че тези инструменти обикновено покриват спецификите на конкретния вид състезание задоволително, те рядко адресират трудностите на дългосрочното съхранение на данни и оперативната съвместимост. В тази статия е представен един софтуерен инструмент адресиращ тези проблеми. Вместо комплексна система, касаеща всички аспекти на състезанието, CORE е централизирано хранилище за съхраняване и поддържане на необходимите за различни състезания данни. Представени са основните му елементи, текущото състояние на реализацията и перспективите за развитие на системата.

Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers.

Tumor genomic instability and selective treatment pressures result in clonal disease evolution; molecular stratification for molecularly targeted drug administration requires repeated access to tumor DNA. We hypothesized that circulating plasma DNA (cpDNA) in advanced cancer patients is largely derived from tumor, has prognostic utility, and can be utilized for multiplex tumor mutation sequencing when repeat biopsy is not feasible. We utilized the Sequenom MassArray System and OncoCarta panel for somatic mutation profiling. Matched samples, acquired from the same patient but at different time points were evaluated; these comprised formalin-fixed paraffin-embedded (FFPE) archival tumor tissue (primary and/or metastatic) and cpDNA. The feasibility, sensitivity, and specificity of this high-throughput, multiplex mutation detection approach was tested utilizing specimens acquired from 105 patients with solid tumors referred for participation in Phase I trials of molecularly targeted drugs. The median cpDNA concentration was 17 ng/ml (range: 0.5-1600); this was 3-fold higher than in healthy volunteers. Moreover, higher cpDNA concentrations associated with worse overall survival; there was an overall survival (OS) hazard ratio of 2.4 (95% CI 1.4, 4.2) for each 10-fold increase in cpDNA concentration and in multivariate analyses, cpDNA concentration, albumin, and performance status remained independent predictors of OS. These data suggest that plasma DNA in these cancer patients is largely derived from tumor. We also observed high detection concordance for critical 'hot-spot' mutations (KRAS, BRAF, PIK3CA) in matched cpDNA and archival tumor tissue, and important differences between archival tumor and cpDNA. This multiplex sequencing assay can be utilized to detect somatic mutations from plasma in advanced cancer patients, when safe repeat tumor biopsy is not feasible and genomic analysis of archival tumor is deemed insufficient. Overall, circulating nucleic acid biomarker studies have clinically important multi-purpose utility in advanced cancer patients and further studies to pursue their incorporation into the standard of care are warranted.