Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.

The vacuolar protein aminopeptidase I (API) uses a novel cytoplasm-to-vacuole targeting (Cvt) pathway. Complementation analysis of yeast mutants defective for cytoplasm-to-vacuole protein targeting (cvt) and autophagy (apg) revealed seven overlapping complementation groups between these two sets of mutants. In addition, all 14 apg complementation groups are defective in the delivery of API to the vacuole. Similarly, the majority of nonoverlapping cvt complementation groups appear to be at least partially defective in autophagy. Kinetic analyses of protein delivery rates indicate that autophagic protein uptake is induced by nitrogen starvation, whereas Cvt is a constitutive biosynthetic pathway. However, the machinery governing Cvt is affected by nitrogen starvation as targeting defects resulting from API overexpression can be rescued by induction of autophagy.

Will this time be different for Greece? How to assess its ability to deliver on the reform agenda. CEPS Commentary, 13 March 2015

Taking its inspiration from the ongoing debate on whether this time will be different for Greece and whether Syriza will deliver on its reform promises to the European partners, this Commentary expresses bemusement that the public debate on such an important issue as well as internal discussions among senior policy-makers frequently resort to ‘gut feelings’ or simple stereotypes. To counteract this tendency, the author presents a simple analytical framework that can be used to assess the likelihood that a government will deliver on its reform agenda. Its purpose is not to allow for a precise probabilistic calculation, but to enable better structuring of the knowledge we have. It emphasises that the change depends NOT only on the capacity of the state to design and deliver policies, but even more crucially on state autonomy from both illegitimate and legitimate interests and cognitive models used by policy-makers to make sense of the world.

Plain reasons addressed to the people of Great-Britain, against the (intended) petition to Parliament from the owners and occupiers of land in the county of Lincoln, for leave to export wool. With some remarks on Sir John Dalrymple's treatise, lately published, in favour of a general exportation of wool.

In manuscript, p. iv : [the author] "The Revd. Sheepshanks, rector of St. Johns in Leeds".

Journal of the Joint Committee on Reconstruction : thirty- ninth Congress, first session : appointed pursuant to the concurrent resolution of December 13, 1865, with direction "to inquire into the condition of the states which formed the so-called Confederate States of America, and report whether they or any of them are entitled to be represented in either house of Congress, with leave to report by bill or otherwise."

Mode of access: Internet.

Speech of Mr. Wright ... on the motion of Mr. Webster for leave to bring in a bill for prolonging the charter of the Bank of the United States; delivered in the Senate of the United States, March 20,1834.

Mode of access: Internet.

Speech of Mr. Benton, of Missouri, on the motion of Mr. Webster, for leave to bring in a bill for prolonging the charter of the Bank of the United States;

Mode of access: Internet.

Letters of the Hon. C.F. Cleveland, and Hon. Henry Hubbard, Governors of Connecticut and New Hampshire, to Samuel Ward King, the charter governor of Rhode Island, refusing to deliver up Thomas Wilson Dorr, ...

Also, the letter of the Hon. Marcus Morton, and others, to the Suffrage Clam-bake.

Using paraprofessionals to deliver education programs.

"April 1986"--P. [2] of cover.

National Labor Relations Board, petitioner, vs. Packard Motor Car Company, respondent : motion of Chrysler Corporation for leave to file a brief as amicus curiae and brief as amicus curiae /

Cover title.

Education (Ireland); speech in the House of Commons on Tuesday, May 19, 1835, on moving for leave to bring in a bill for the establishment of a Board of National Education, and the advancement of elementary education in Ireland.

"Extracted from the 'Mirror of Parliament'."