Mesh traversal and sorting for efficient memory usage in scientific codes

Applications that operate on meshes are very popular in High Performance Computing (HPC) environments. In the past, many techniques have been developed in order to optimize the memory accesses for these datasets. Different loop transformations and domain decompositions are com- monly used for structured meshes. However, unstructured grids are more challenging. The memory accesses, based on the mesh connectivity, do not map well to the usual lin- ear memory model. This work presents a method to improve the memory performance which is suitable for HPC codes that operate on meshes. We develop a method to adjust the sequence in which the data are used inside the algorithm, by means of traversing and sorting the mesh. This sorted mesh can be transferred sequentially to the lower memory levels and allows for minimum data transfer requirements. The method also reduces the lower memory requirements dra- matically: up to 63% of the L1 cache misses are removed in a traditional cache system. We have obtained speedups of up to 2.58 on memory operations as measured in a general- purpose CPU. An improvement is also observed with se- quential access memories, where we have observed reduc- tions of up to 99% in the required low-level memory size.

El límite y su reversibilidad

La propuesta busca desarrollar herramientas nuevas para entendimiento de los límites y bordes arquitectónicos. Entendiendo las características tanto físicas como psicológicas de los límites, busco que la arquitectura que se propone genere una ruptura de las simplistas contraposiciones binarias que se encuentran en la base de la comprensión arquitectónica tradicional; los conceptos de interior / exterior, dentro / fuera, sujeto / objeto, ciudad / campo, naturaleza/ artificio; son desde mi punto de vista atavismos que deben ser superados para poder producir una arquitectura acorde a los nuevos tiempos, que se adapte a las condicionantes de su entorno. Al entender que los límites encarnan la existencia de situaciones duales e hibridas, que suceden a los dos lados del límite busco aprovechar las situaciones de tensión, negación, negociación, confrontación, contraposición, etc., la propuesta busca poner en valor las características de convivencia, dialogo y relación de la ciudad tradicional. Es decir las características políticas de la polis y la civitas. Entendiendo que el hombre es un animal político por excelencia, la propuesta busca potenciar el carácter político y de socialización de la arquitectura. Por medio del entendimiento de las relaciones y espacializaciones que generan los choques cuerpos en el espacio; y la necesidad de que los límites de la arquitectura y la ciudad sean transgredidos física y programáticamente para que adquieran un carácter más dinámico y poroso que ayuden a esta relación. La propuesta introduce ejemplos de líneas de fuga y rupturas, que se puedan materializar mediante pequeñas intervenciones. Intervenciones arquitectónicas, que a pesar de sus limitados recursos formales, puedan generar resultados exponencialmente superiores que transformen las condiciones iniciales del sitio. The proposal seeks to develop new tools for the understanding of the Architectural limits and borders. By understanding of limit`s physical and psychological qualities, I seek that architecture could generate a breakdown of the simplistic binary oppositions that are at the base of the traditional Architectural understanding; concepts such as interior / exterior, inside / outside, object/subject, city/countryside, nature/artifice; They are from my point of view atavism that must be overcome in order to produce an architecture according to the times, that suit the conditions of their milieu. By understanding that limits embodies the existence of dual and hybrid situations that occur on both sides of the limit, I manage to take stressful situations of , denial, bargaining, confrontation, contrast, etc., the proposal seeks to assess the characteristics of living , dialogue and respect of the traditional city. I.e. the political characteristics of the polis and civitas. By realizing that the man is a political animal par excellence, the proposal seeks to strengthen political and socialization architectural character. Through the understanding of spatial relationships that shocking bodies generates in space; and the need for architecture and city limits get physically and programmatically transgressed to acquire a more dynamic and porous nature that helps in this relationship. The proposal introduces examples of flight lines and breaks, which can be realized through small interventions. Architectural interventions, despite his limited formal resources can generate exponentially greater results that transform the initial conditions of the site.

Un deseo moderno todavía pendiente : la casa patio, una posible técnica de agrupación de vivienda colectiva vertical

La idea de aportar a la vivienda en altura las cualidades de la casa patio, se ha estudiado durante años. Podemos decir que el origen de este análisis se inició en 1922 cuando Le Corbusier empezó a investigar a cerca de los Inmuebles Villa; sin duda sabemos que ha llegado hasta la actualidad. Ayudado por la labor de búsqueda de diferentes arquitectos a lo largo de la historia, podemos afirmar que todos los casos conforman una idea única de proyecto. La idea de agrupar casas patio en altura manteniendo las características propias de este tipo de viviendas, privacidad, espacio libre, apertura cenital, comunicación interior‐exterior… Los Inmuebles‐Villa serán repetidamente aludidos, citados o retomados como un tipo paradigmático entre las propuestas de agrupaciones de casas patio en altura. Si pensamos en el concepto tradicional de patio, denominarlo como un espacio de viviendas apiladas en altura no parece una elección adecuada, no obstante la noción de patio permite una gran cantidad de asociaciones. Su valor radica en el traslado de una idea conocida a un nuevo contexto, produciendo así una reformulación del problema. Elegimos para este proceso, la vivienda colectiva, entendiendo la colectividad como agrupación, pues es esta agrupación de vivienda la encargada de crear ciudad; así no sólo vale la pena dar importancia a una célula con su independencia, sino en la relación que estas establecen con sus semejantes. De ahí la idea de que esa colectividad de casas patio, pueda darse también en vertical, buscando las condiciones antes mencionadas. Un deseo que apareció en el Movimiento Moderno y que desde ese momento ha sido algo anhelado por la arquitectura hasta nuestros días. El patio se presenta en la mayoría de las ocasiones como un espacio con múltiples afecciones, desde el patio que aporta a la vivienda una zona de esparcimiento hasta un espacio destinado a la ventilación, aunque en definitiva, podemos decir que consiste en un espacio capaz de contener un lugar. Quizás por eso aparece de diversas formas en nuestra arquitectura, sin importar su ubicación o forma. Simplemente un espacio que aporta al interior unas características que esas viviendas nunca alcanzarían sin él. Por eso lo que conocemos como casa patio es un tipo de arquitectura que se extiende hasta la antigüedad. Ese concepto de espacio exterior incorporado a la vivienda es una de las piezas fundamentales en nuestra arquitectura. Una idea ampliamente estudiada que deja a un lado los diferentes tipos de “patio” que fueron apareciendo, así como las múltiples funciones que dichos espacios fueron capaces de llevar a cabo, primando en definitiva la forma en la que cambiaron la idea de habitar. A lo largo de este análisis se han ido hallando evidencias de los múltiples mecanismos empleados en los casos estudiados. Como se ha visto, en ellos aparecen características que únicamente pueden aparecer en un espacio exterior cuando se trata de un patio. Los patios estudiados se consideran patios tradicionales, independientemente de la cota a la que se encuentren, aunque no cumplan alguna de las características a priori necesarias para la definición de patio. Para captar la esencia de esos espacios, no es necesario traspasar sus límites, ya que ésta se irradia al interior e invade la atmósfera de los espacios contiguos. Se plantea como objetivo principal rastrear las huellas de una investigación proyectual que Le Corbusier inaugura y deja abierta; se trata de descubrir qué ecos, qué rebotes, qué repercusiones tiene el concepto de patio en altura a lo largo de su historia. En esta búsqueda de identificación de las características de estos espacios, hemos seleccionado tres casos, partiendo de las experiencias tanto en patios tradicionales como en patios en altura de tres maestros como son Le Corbusier, José Luis Sert y Charles Correa. Los casos estudiados podrían haber sido muchos más. Este número supone solo un ejemplo de un universo mayor, que ha sido operativo para el desarrollo de este trabajo. Ellos nos guiarán por su arquitectura para intentar resolver la idea de los patios en altura. Hemos analizado las influencias proyectuales existentes entre algunos de los casos que forman parte de esta reflexión, entre los que existen unos vínculos claros, que pueden ser esas claves que estamos buscando para resolver la agrupación de casa patio en altura. A través de este trabajo se ha puesto de manifiesto que la aplicación del concepto de casas patio en altura depende tanto de su ubicación, del clima y la cultura local, como el tipo de patio del que se parte. De estos conceptos surgen soluciones diferentes entre ellas y por tanto no pueden extrapolarse una sola idea a todos los casos. Algunas ideas están presentes durante toda la investigación: fachadas como resultado de la repetición de células, sucesión de espacios, plantas de casas patio tradicional, dobles alturas…Otros casos destacan por su singularidad, por haber buscado la solución del problema mediante la originalidad. En definitiva buscamos casas patio en altura. Y si esta tesis contribuye, en alguna medida, a obtener las claves para que esta tipología edificatoria funcione, de sus características, sus necesidades, y su resultado, es decir, de su búsqueda de ese deseo moderno que presentábamos al principio, será entonces que esa tipología ilusoria, sea una arquitectura real, y por lo tanto también podrá llevarse a cabo y dejar de ser un deseo para convertirse en realidad. Sera que el deseo moderno se ha cumplido. ABSTRACT The idea of giving housing the height of the patio housing qualities, it has been studied for ages. It can be said that the origin of this analysis was started in 1922, when Le Cobustier began investigating about The Villa Building: obviously it is known nowadays due to different architect’s labor of searching through the history. It’s easy to say that all the cases shape a single project idea , the idea of gathering patio houses with the same height keeping the inner characteristics of traditional patio houses such privacy, free space, zenithal opening, inside –outside communication…etc. If we thought about the traditional concept of patio, to define it, in the case of gathering because of the height, it is not suitable to consider it like a pile of houses with the same height. Nevertheless the concept of patio allows a wide variety of settlements. Its worth is based on the transference of a renowned idea into a new context, producing thus a reformulation of the problem. The patio is frequently disposed like a zone with multiple utilities, from the leisure zone patio to an air circulating space, definitively it can be said that it consists on a space which is able to content a place. Maybe that is why it appears in various forms in our architecture, regardless of its placement or shape. It is simply a space which provides many features which are impossible to reach without it. That is what we know as patio house is a type of architecture which is spread till antiquity. This concept of outdoors space joined housing is one of the main pieces of our architecture. It is an idea wide analyses which lefts aside the different types of patios which were developed, focusing mainly the way they changed the idea of inhabiting. We have chosen for this analysis process, the collective housing, we understood collective like group, thus it is the group of housing responsible to built up a city, not just it is worth to give importance to an independent cell, in addition to the relation which those ones can stablish with their similar ones. Due to the idea of collectivity of patio houses, it can be also developed in vertical, looking for the previously mention condition. A wish which appeared with the modern movement and since then it has been something desired by architecture just nowadays. It is understood as the main target to follow the trail about a project investigation which was begun and left open by Le Cobustier: the task is discovering the resonances, the bounces and repercussions which belong to the patio concept in height through its history. In this quest to distinguish the characteristics of these spaces, we have chosen three cases, starting from the experiences as traditional patios as in the height of patios of the masters such as Le Cobustier, Jose Luis Sert and Charles Correa. The studied cases could be even more. This number is just an example of a huger universe, which has been operational for the developing of this work. We will be managed through their architecture trying to solve the idea of patios according to their height. Over this analysis evidences there are found multiple mechanics used in the studied cases. As we could see later, in these ones there are characteristics which are only found in an outdoors space when it is a patio. The studied patios are considered traditional patios, independently of the level they have, although they do not fit at first some of the necessary characteristics included in a patio definition. To catch the essence of those spaces, it is not necessary to go through its limits, since it is transmitted to the interior and pervades the adjoining spaces. It has been analyzed the project influences exiting among several cases which build up part of this consideration , among them there are some clear links, which may be these keys we are looking for to solve the joint of patio houses in height. With this work it has been highlighted that the application of the patios houses in height concept depends not only on its placement, the weather and the local culture, but also on the type of patio we are using. From these considerations different solutions were given by themselves as consequence they can be extrapolated into a single idea for all the cases. Some ideas are present along the complete investigation: facades resulting from cells repetition, series of spaces, traditional patio house floor, double height… Some other cases stand out due to it singularity, because they have searched for a solution to the problem by means of originality. To sum up, we look for patio houses in height. And if this thesis contributes, in some way, to get the clues to make work this type of building, about its characteristics, its necessities and its result, in other words, its searching of this modern desire that we showed at the beginning, then this imaginary typo will be a real architecture therefore it can also come truth and can abandon the form of wish to became into a reality. So the modern desire has been fulfilled.

南スーダンにおけるハイブリッド刑事法廷設置の試み -- 外と内の論理からの考察

2011年にスーダンから独立した南スーダンは、2013年12月に政府側と反政府側との間で大規模な衝突を経験する。この衝突は、民族紛争の様相を呈し、政府および反政府の両者が、市民を巻き込む大規模な人権侵害に関与したと言われている。国際社会は、国際的な刑事裁判所の必要性を訴えるが、通常、政府の関与が疑われる中、人権侵害を捜査・訴追することを目的とした国際的な刑事司法のメカニズムを設置することは困難である。しかし、南スーダン政府は、2015年8月、南スーダンハイブリッド刑事法廷設置に言及した「南スーダンにおける衝突の解決に関する合意文書」に署名する。本稿ではハイブリッド刑事法廷をめぐる、国際社会と南スーダン政府のそれぞれの論理を紐解くことで、2015年8月合意文書にハイブリッド刑事法廷の設置が含まれ、アフリカ連合が同法廷の設置を主導していることの背景を明らかにする。

English Language Learning Inside and Outside the Classroom in Portugal

This study investigates the way of learning the English language in Portugal. First-year students of the faculty of Social Sciences and Humanities of New University of Lisbon were selected as participants in the case study. As data collection tools a questionnaire and focus-groups were used. 115 students completed the designed questionnaire and after that 12 students were selected for the more detailed focus-group discussions. Results of the research show that most part of the students´ English knowledge is received from outside the classroom by means of movies, songs, computer games, the Internet, communication with friends and other sources. Also, the results show that motivation is very important in language learning process and motivated students acquire the language faster and easier.

"Public on the outside, private on the inside": the organizational hybridization, sense of belonging and identity strategies of the employees of a public unemployment insurance fund in Switzerland

A number of studies show that New Public Management reforms have altered the current identity benchmarks of public officials, particularly by hybridizing values or management practices. However, existing studies have largely glossed over the sense of belonging of officials when their organization straddles the concerns of public service and private enterprise, so that the boundary between public and private sector is blurred. The purpose of this article is precisely to explore this sense of belonging in the context of organizational hybridization. It does so by drawing on the results of research conducted among the employees of a public unemployment insurance fund in Switzerland. On the one hand, the analysis shows how much their markers of belonging are hybrid, multiple and constructed in negative terms (with regard to the State), while indicating that the working practices of the employees point to an identity that is nevertheless closely bound with the public sector. On the other hand, the analysis shows that the organization plays strategically with its State status, by exploiting either its private or public identity in line with the needs related to its external image. The article concludes with a discussion of the results highlighting the strategic functionality of the hybrid identity of the actors.

Simian malaria at two sites in the Brazilian Amazon - II: Vertical distribution and frequency of anopheline species inside and outside the forest

An anopheline survey was carried out in two simian malaria areas in the Brazilian Amazon, Balbina and Samuel, to determine the potential vectors of Plasmodium brasilianum. The most abundant and/or acrodendrophilic anophelines in the forest and the most likely vector were Anopheles mediopunctatus, An. nuneztovari, An. oswaldoi, An. triannulatus and An. shannoni. An. darlingi and An. marajoara were captured essentially in anthropic habitats outside the forest and are unlikely to be involved in the transmission of P. brasilianum among monkeys within the forests and from monkeys to man in their surroundings in the Amazon.

A Comparative Study of Transvaginal Tape, Transobturator Tape Outside-in, and Transvaginal Tape-obturator Inside-out Surgical Procedures in the Treatment of Stress Urinary Incontinence

The aim of this work was to use the Urinary Distress Inventory (UDI-6) and Incontinence Impact Quality of Life (IIQ-7) questionnaires to compare 3 surgical techniques for stress urinary incontinence: the transvaginal tape (TVT) (105 women), the transobturator tape outside-in (TOT) (43 women), and the transvaginal tape-obturator inside-out (TVT-O) (54 women). There were no significant differences in frequent urination, urine leakage related to the feeling of urgency, urine leakage related to physical activity, or small amounts of urine leakage. TVT-operated women had a lower percentage of micturition difficulties compared with TOT women. TVT-O-operated women described slight discomfort in the genital area compared with the TVT technique, but this difference was not significant when compared with the TOT technique. When utilizing the UDI-6 and IIQ-7 scoring modifications before and after surgery, no difference among these 3 techniques is apparent.

Effect of the environment inside and outside the cage on the activity and behaviour test performance of silver foxes

Selostus: Kasvatushäkin ympäristön vaikutus hopeakettujen käyttäytymiseen

Transobturator surgery for female stress incontinence: a comparative anatomical study of outside-in vs inside-out techniques.

OBJECTIVE To assess the specific risks of injury to neural and vascular structures inherent in two approaches to transobturator surgery for inserting a suburethral sling, i.e. the outside-in (standard technique) and inside-out approaches. MATERIALS AND METHODS The study comprised seven cadavers, providing 14 obturator regions. Five specimens had a tape inserted outside-in on one side, and inside-out on the other; of the remaining two cadavers, one had an inside-out tape and one an outside-in tape, bilaterally. After tape insertion, the cadavers were dissected. Particular attention was paid to the distances between the tape and the deep external pudendal vessels, and between the tape and the posterior branch of the obturator nerve. RESULTS With the inside-out technique, the safety margins were reduced, and the external pudendal vessels and the posterior branch of the obturator nerve were at greater risk of injury. CONCLUSION The two techniques are not equivalent, with a lower risk of injury to vascular and nerve structures with the outside-in technique.

How Immigrant Mothers Contribute to Their Children’s Learning Inside and Outside of School

Abstract The main focus of this qualitative research was to explore how parents from different national backgrounds see their role in their children’s education inside and outside of school. Although greater recruitment was described and sought after, this qualitative research gathered data from two immigrant female parents from a community parents’ group located in Ontario, Canada. Data were collected through face-to-face interviews with each participant using open-ended questions asking about the different ways these mothers, along with their spouses, were involved in their children’s education. Moreover, questions were designed to find out what alternatives parents use to support their children’s learning. The main question driving this research was “How are immigrant families currently involved with their children’s education inside and outside of school?” NVivo, 10 was used to code the transcripts giving rise to themes which could then be utilized to explain and explore the research question. The findings of this research are congruent with past research and demonstrate that immigrant mothers are more involved than the fathers are in their children’s education (Grolnick & Slowiaczek 1994; Peters, Seeds, Goldstein, & Coleman, 2008). A specifically important finding in this research is that schools are perceived by the immigrant mothers in this study as not doing enough to actively engage immigrant parents in their children’s education. On the other hand, findings also show that parents are eager to find different avenues to get involved and help their children succeed.

Reflections of reflections : authors, narrators and worlds inside and outside of autobiographical fiction

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Not the outside but the inside matters : functional analysis of Capricious and Tartan during Drosophila tracheal morphogenesis

The tubular structures, which transport essential gases, liquids, or cells from one site to another, are shared among various divergent organisms. These highly organized tubular networks include lung, kidney, vasculature and mammary gland in mammals as well as trachea and salivary gland in Drosophila melanogaster. Many questions regarding the tubular morphogenesis cannot be addressed sufficiently by investigating the mammalian organs because their structures are extremely complex and therefore, systematic analyses of genetic and cellular programs guiding the development is not possible. In contrast, the Drosophila tracheal development provides an excellent model system since many molecular markers and powerful tools for genetic manipulations are available. Two mechanisms were shown to be important for the outgrowth of tracheal cells: the FGF signaling pathway and the interaction between the tracheal cells and the surrounding mesodermal cells. The Drosophila FGF ligand encoded by branchless (bnl) is localized in groups of cells near tracheal metameres. The tracheal cells expressing the FGF receptor breathless (btl) respond to these sources of FGF ligand and extend towards them. However, this FGF signaling pathway is not sufficient for the formation of continuous dorsal trunk, the only muticellular tube in tracheal system. Recently, it was found out that single mesodermal cells called bridge-cells are essential for the formation of continuous dorsal trunk as they direct the outgrowth of dorsal trunk cells towards the correct targets. The results in this PhD thesis demonstrate that a cell adhesion molecule Capricious (Caps), which is specifically localized on the surface of bridge-cells, plays an essential role in guiding the outgrowing dorsal trunk cells towards their correct targets. When caps is lacking, some bridge-cells cannot stretch properly towards the adjacent posterior tracheal metameres and thus fail to interconnect the juxtaposing dorsal trunk cells. Consequently, discontinuous dorsal trunks containing interruptions at several positions are formed. On the other hand, when caps is ectopically expressed in the mesodermal cells through a twi-GAL4 driver, these mesodermal cells acquire a guidance function through ectopic caps and misguide the outgrowing dorsal trunk cells in abnormal directions. As a result, disconnected dorsal trunks are formed. These loss- and gain-of-function studies suggest that Caps presumably establishes the cell-to-cell contact between the bridge-cells and the tracheal cells and thereby mediates directly the guidance function of bridge-cells. The most similar protein known to Caps is another cell adhesion molecule called Tartan (Trn). Interestingly, trn is expressed in the mesodermal cells but not in the bridge-cells. When trn is lacking, the outgrowth of not only the dorsal trunks but also the lateral trunks are disrupted. However, in contrast to the ectopic expression of caps, the misexpression of trn does not affect tracheal development. Whereas Trn requires only its extracellular domain to mediate the matrix function, Caps requires both its extracellular and intracellular domains to function as a guidance molecule in the bridge-cells. These observations suggest that Trn functions differently from Caps during tracheal morphogenesis. Presumably, Trn mediates a matrix function of mesodermal cells, which support the tracheal cells to extend efficiently through the surrounding mesodermal tissue. In order to determine which domains dictate the functional specificity of Caps, two hybrid proteins CapsEdTrnId, which contains the Caps extracellular domain and the Trn intracellular domain, and TrnEdCapsId, which consists of the Trn extracellular domain and the Caps intracellular domain, were constructed. Gain of function and rescue experiments with these hybrid proteins suggest on one hand that the extracellular domains of Caps and Trn are functionally redundant and on the other hand that the intracellular domain dictates the functional specificity of Caps. In order to identify putative interactors of Caps, yeast two-hybrid screening was performed. An in vivo interaction assay in yeast suggests that Ras64B interacts specifically with the Caps intracellular domain. In addition, an in vitro binding assay reveals a direct interaction between an inactive form of Ras64B and the Caps intracellular domain. ras64B, which encodes a small GTPase, is expressed in the mesodermal cells concurrently as caps. Finally, a gain-of-function study with the constitutively active Ras64B suggests that Ras64B presumably functions downstream of Caps. All these results suggest consistently that the small GTPase Ras64B binds specifically to the Caps intracellular domain and may thereby mediate the guidance function of Caps.

Deletion Analysis of 15 exons located outside and inside a “Hot Spot” in the Duchenne Muscular Dystrophy gene in Duchenne’s Muscular dystrophy patients

Introduction. Duchenne and Becker Muscular Dystrophies (DMD/DMB) are X-linked recessive diseases characterized by progressive muscle weakness and wasting, loss of motor skills and death after the second decade of life. Deletions are the most prevalent mutations that affect the dystrophin gene, which spans 79 exons.Objective: Identify deletions on the dystrophin gene in 58 patients affected with DMD.Methods: Through multiplex PCR identify deletions on the dystrophin gene in 58 patients with DMD and observe the frequency of this mutation in our population.Results: We found deletions in 1.72% of patients (1 of 58 persons). Deletions were not the principal cause of disease in our population. It is possible that duplications and point mutations caused this illness in our patients.Conclusions: The frequency of deletions in the 15 exons analyzed from the dystrophin gene was low. The predominant types of mutation in our patients` samples were not deletions as has been observed in the literature worldwide, therefore, it is important to determine other types of mutations as are duplications and point mutations.