Transformations of heavy metals and plant nutrients in dredged sediments as affected by oxidation reduction potential and pH : final report /

"May 1977."

Why people drink and drive: the bases of drinking-and-driving decisions. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Occupant response and vehicle acceleration in a 30 mph frontal impact test - 1981 Ford F150 Custom Explorer Styleside - Pickup - NHTSA 810602. Final report.

National Highway Traffic Safety Administration, Office of Passenger Vehicle Research, Washington, D.C.

Driver performance and individual differences in attention and information processing. Volume I: driver inattention. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Driver performance and individual differences in attention and information processing. Volume II: field dependence and highway safety. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

A review of motorcycle crash bars and their role in injury prevention. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Occupant response and vehicle acceleration in a 30 mph frontal impact test - 1981 Subaru DL - 4 wheel drive - 4 door wagon - NHTSA 811301. Final report.

National Highway Traffic Safety Administration, Office of Passenger Vehicle Research, Washington, D.C.

Specification and data presentation in linear control systems; [final report,

"EE 61-4. Research project PRF 30. Contract no. AF 29(600)-1933."

A Plan for research on floods and their mitigation in the United States : final report to National Science Foundation /

"SWS contract report 302."

A socio-psychological study of conforming and deviating behavior among adolescents; a final report of research under contract project 507 (8133) a cooperative research project of the United States Office of Education and the State University of Iowa. Project staff: Albert J. Reiss, Jr., project director [and] Albert Lewis Rhodes, research associate.

"The first two years of this three year project were undertaken as Cooperative Research Project 6399, by Vanderbilt University and the U.S. Office of Education."

A functional description of the Edvac [an automatically-sequence serial binary electronic digital computer. Final report of work under contract W36-034-ORD-7593 between the Ordinance Department, Department of the Army and the University of Pennsylvania, Moore School of Electrical Engineering.

Errata, as of Apr. 1, 1950 (7 ¹., 2 diagrs.) inserted.

Genetic variability and natural selection at the ligand domain of the Duffy binding protein in brazilian Plasmodium vivax populations

Background: Plasmodium vivax malaria is a major public health challenge in Latin America, Asia and Oceania, with 130-435 million clinical cases per year worldwide. Invasion of host blood cells by P. vivax mainly depends on a type I membrane protein called Duffy binding protein (PvDBP). The erythrocyte-binding motif of PvDBP is a 170 amino-acid stretch located in its cysteine-rich region II (PvDBP(II)), which is the most variable segment of the protein. Methods: To test whether diversifying natural selection has shaped the nucleotide diversity of PvDBP(II) in Brazilian populations, this region was sequenced in 122 isolates from six different geographic areas. A Bayesian method was applied to test for the action of natural selection under a population genetic model that incorporates recombination. The analysis was integrated with a structural model of PvDBP(II), and T-and B-cell epitopes were localized on the 3-D structure. Results: The results suggest that: (i) recombination plays an important role in determining the haplotype structure of PvDBP(II), and (ii) PvDBP(II) appears to contain neutrally evolving codons as well as codons evolving under natural selection. Diversifying selection preferentially acts on sites identified as epitopes, particularly on amino acid residues 417, 419, and 424, which show strong linkage disequilibrium. Conclusions: This study shows that some polymorphisms of PvDBP(II) are present near the erythrocyte-binding domain and might serve to elude antibodies that inhibit cell invasion. Therefore, these polymorphisms should be taken into account when designing vaccines aimed at eliciting antibodies to inhibit erythrocyte invasion.

Role of kinin B1 and B2 receptors in memory consolidation during the aging process of mice

Under physiological conditions, elderly people present memory deficit associated with neuronal loss. This pattern is also associated with Alzheimer`s disease but, in this case, in a dramatically intensified level. Kinin receptors have been involved in neurodegeneration and increase of amyloid-beta concentration, associated with Alzheimer`s disease (AD). Considering these findings, this work evaluated the role of kinin receptors in memory consolidation during the aging process. Male C57BI/6 (wt), knock-out B1 (koB1) or B2 (koB2) mice (3, 6, 12 and 18-month-old - mo; n = 10 per group) were submitted to an acquisition session, reinforcement to learning (24 h later: test 1) and final test (7 days later: test 2), in an active avoidance apparatus, to evaluate memory. Conditioned avoidance responses (CAR, % of 50 trials) were registered. In acquisition sessions, similar CAR were obtained among age matched animals from all strains. However, a significant decrease in CAR was observed throughout the aging process (3mo: 8.8 +/- 2.3%; 6mo: 4.1 +/- 0.6%; 12mo: 2.2 +/- 0.6%, 18mo: 3.6 +/- 0.6%, P < 0.01), indicating a reduction in the learning process. In test 1, as expected, memory retention increased significantly (P < 0.05) in all 3- and 6-month-old animals as well as in 12-month-old-wt and 12-month-old-koB1 (P < 0.01), compared to the training session. However, 12-month-old-koB2 and all 18-month-old animals did not show an increase in memory retention. In test 2, 3- and 6-month-old wt and koB1 mice of all ages showed a significant improvement in memory (P < 0.05) compared to test 1. However, 12-month-old wt and koB2 mice of all ages showed no difference in memory retention. We suggest that, during the aging process, the B1 receptor could be involved in neurodegeneration and memory loss. Nevertheless, the B2 receptor is apparently acting as a neuroprotective factor. (C) 2009 Elsevier Ltd. All rights reserved.