Using an animated pedagogical agent to interact affectively with the student

This work proposes an animated pedagogical agent that has the role of providing emotional support to the student: motivating and encouraging him, making him believe in his self-ability, and promoting a positive mood in him, which fosters learning. This careful support of the agent, its affective tactics, is expressed through emotional behaviour and encouragement messages of the lifelike character. Due to human social tendency of anthropomorphising software, we believe that a software agent can accomplish this affective role. In order to choose the adequate affective tactics, the agent should also know the student’s emotions. The proposed agent recognises the student’s emotions: joy/distress, satisfaction/disappointment, anger/gratitude, and shame, from the student’s observable behaviour, i. e. his actions in the interface of the educational system. The inference of emotions is psychologically grounded on the cognitive theory of emotions. More specifically, we use the OCC model which is based on the cognitive approach of emotion and can be computationally implemented. Due to the dynamic nature of the student’s affective information, we adopted a BDI approach to implement the affective user model and the affective diagnosis. Besides, in our work we profit from the reasoning capacity of the BDI approach in order for the agent to deduce the student’s appraisal, which allows it to infer the student’s emotions. As a case study, the proposed agent is implemented as the Mediating Agent of MACES: an educational collaborative environment modelled as a multi-agent system and pedagogically based on the sociocultural theory of Vygotsky.

Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt– Jakob disease: Implications for human health

There is substantial scientific evidence to support the notion that bovine spongiform encephalopathy (BSE) has contaminated human beings, causing variant Creutzfeldt–Jakob disease (vCJD). This disease has raised concerns about the possibility of an iatrogenic secondary transmission to humans, because the biological properties of the primate-adapted BSE agent are unknown. We show that (i) BSE can be transmitted from primate to primate by intravenous route in 25 months, and (ii) an iatrogenic transmission of vCJD to humans could be readily recognized pathologically, whether it occurs by the central or peripheral route. Strain typing in mice demonstrates that the BSE agent adapts to macaques in the same way as it does to humans and confirms that the BSE agent is responsible for vCJD not only in the United Kingdom but also in France. The agent responsible for French iatrogenic growth hormone-linked CJD taken as a control is very different from vCJD but is similar to that found in one case of sporadic CJD and one sheep scrapie isolate. These data will be key in identifying the origin of human cases of prion disease, including accidental vCJD transmission, and could provide bases for vCJD risk assessment.

The design of an agent to bend DNA.

An artificial DNA bending agent has been designed to assess helix flexibility over regions as small as a protein binding site. Bending was obtained by linking a pair of 15-base-long triple helix forming oligonucleotides (TFOs) by an adjustable polymeric linker. By design, DNA bending was introduced into the double helix within a 10-bp spacer region positioned between the two sites of 15-base triple helix formation. The existence of this bend has been confirmed by circular permutation and phase-sensitive electrophoresis, and the directionality of the bend has been determined as a compression of the minor helix groove. The magnitude of the resulting duplex bend was found to be dependent on the length of the polymeric linker in a fashion consistent with a simple geometric model. Data suggested that a 50-70 degrees bend was achieved by binding of the TFO chimera with the shortest linker span (18 rotatable bonds). Equilibrium analysis showed that, relative to a chimera which did not bend the duplex, the stability of the triple helix possessing a 50-70 degrees bend was reduced by less than 1 kcal/mol of that of the unbent complex. Based upon this similarity, it is proposed that duplex DNA may be much more flexible with respect to minor groove compression than previously assumed. It is shown that this unusual flexibility is consistent with recent quantitation of protein-induced minor groove bending.

Letters from Thomas Handasyd Perkins to William Tudor,

Three letters written to Tudor in Peru. Perkins responds to Tudor’s reports on the prospects of trade in South America and reflects on other issues relating to trade. He also relays details of Lafayette’s visit to America and the public’s reception. One letter discusses Spanish pressure on the United States relating to the war and responds to Tudor’s letters regarding the General Carrington. He also comments on the election at home: "Adams will probably be president."

Letters from Thomas Handasyd Perkins to William Tudor,

Five letters in which Perkins comments on the political landscape in the United States, the election of Andrew Jackson as president, Boston architectural and real estate developments, and the Granite Railway and granite quarries in Quincy.

Letters from Thomas Handasyd Perkins to William Tudor,

Four letters in which Perkins relays details of his travels in Europe, local gossip about friends and associates, including John Quincy Adams and Daniel Webster, news regarding developments in Boston infrastructure, and updates on the Boston Athenaeum and the Anthology Society. Other topics include domestics politics and the movements and activities of Tudor’s family members.

Letters from Thomas Dickason & Co. to William Tudor,

Four letters regarding the "miserable" sales of Tudor’s cocoa and various financial transactions.

Letters from Thomas Dickason & Co. to William Tudor,

Four letters regarding billings, the movements of Tudor’s cargo, and sundry items Tudor ordered through the firm.

Letters from Thomas Dickason & Co. to William Tudor,

Two letters regarding bills outstanding.

Letters from Thomas James Maling to William Tudor,

Two letters regarding peace negotiations in Buenos Aires and politics in Europe, and two letters from Maling’s wife regarding accommodations she was seeking in Lima and news regarding various sailing vessels.

An answer to Lord Sheffield's pamphlet, on the subject of the navigation system : proving, that the acts deviating therefrom, which His Lordship censures, were beneficial to our trade and navy, in the last war, and ought to be renewed in the present /

"Memorial of the merchants of London": p. [72-75].

Nominations of Thomas F. McBride to be Inspector General, U.S. Department of Agriculture, and Daniel Marcus to be General Counsel, U.S. Department of Agriculture [microform] : hearings before the Committee on Agriculture, Nutrition, and Forestry, United States Senate, Ninety-sixth Congress, first session, May 23 and June 20, 1979.

Reuse of record except for individual research requires license from Congressional Information Service, Inc.

Italy, its condition, Great Britain, its policy : a series of letters addressed to Lord John Russell, M.P. /

Mode of access: Internet.