The whistler at the plough, containing travels, statistics, and descriptions of scenery & agricultural customs in most parts of England, with Letters from Ireland : also "Free trade and the League;" a biographic history.

"This volume comprises a selection of letters and essays, written by me, and addressed to the demerits of protection, from 1842 to 1847, inclusive. The two succeeding volumes are a biographic history of free trade and the League. They embrace memoirs of persons identified with the rise and progress of commerce and constitutional liberty, from earliest English history to 1850."-Dedication to vol. 1.

Whistler v. Ruskin : art & art critics /

Printed brown paper cover dated Dec. 24, 1878.

First editions and manuscripts of Rudyard Kipling, George Moore, Stevenson, Whitman, Whistler, Bliss Carman, Lord Dunsany ... The Kelmscott Chaucer ... Order of sale, ... October 17, 1921, lots 1-290 ... October 18, 1921, lots 291-570. The Anderson galleries ... New York.

570 entries, priced.

Whistler,

Mode of access: Internet.

Memories of James McNeill Whistler, the artist /

"All the illustrations have been printed by lithography by T. Way ... except the etching "Fitzroy Square" ... and the photogravure of the "Thewhite Lady" ..."--P. xi.

Whistler,

Mode of access: Internet.

Exposition des oeuvres de James McNeill Whistler. Palais de l'École des beaux-arts.

Paris, May, 1905.

Select letters between the late Duchess of Somerset, Lady Luxborough, Mr. Whistler, Miss Dolman, Mr. R. Dodsley, William Shenstone, and others; including a sketch of the manners, laws &c. of the Republic of Venice, and some poetical pieces; the whole now first published from original copies.

The letters are for the most part by or to William Shenstone.

The art of James McNeill Whistler : an appreciation /

"Works by James McNeill Whistler exhibited at the Royal academy": p. 119-121.

Whistler, and others /

"The first, third, tenth and fifteenth chapters in the present volume have seen the light already in ʻthe Nineteenth century'; the ninth is re-arranged from ʻthe Anglo-Saxon review'; and the sixteenth reprinted from ʻthe Magazine of fine arts' ... Certain of the remarks in other portions of this book were first made in the ʻStandard'."--Note.

Whistler, and others,

"The first, third, tenth and fifteenth chapters in the present volume have seen the light already in 'the Nineteenth century'; the ninth is re-arranged from 'the Anglo-Saxon review'; and the sixteenth reprinted from 'the Magazine of fine arts' ... Certain of the remarks in other portions of this book were first made in the 'Standard.'"--Note.

Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence

Abstract Opioid drugs, such as morphine, are among the most effective analgesics available. However, their utility for the treatment of chronic pain is limited by side effects including tolerance and dependence. Morphine acts primarily through the mu-opioid receptor (MOP-R) , which is also a target of endogenous opioids. However, unlike endogenous ligands, morphine fails to promote substantial receptor endocytosis both in vitro, and in vivo. Receptor endocytosis serves at least two important functions in signal transduction. First, desensitization and endocytosis act as an "off" switch by uncoupling receptors from G protein. Second, endocytosis functions as an "on" switch, resensitizing receptors by recycling them to the plasma membrane. Thus, both the off and on function of the MOP-R are altered in response to morphine compared to endogenous ligands. To examine whether the low degree of endocytosis induced by morphine contributes to tolerance and dependence, we generated a knockin mouse that expresses a mutant MOP-R that undergoes morphine-induced endocytosis. Morphine remains an excellent antinociceptive agent in these mice. Importantly, these mice display substantially reduced antinociceptive tolerance and physical dependence. These data suggest that opioid drugs with a pharmacological profile similar to morphine but the ability to promote endocytosis could provide analgesia while having a reduced liability for promoting tolerance and dependence

Dopamine responsiveness is regulated by targeted sorting of D2 receptors

Abstract Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated sorting protein (GASP). As a consequence of this GASP interaction, D2 responses in rat brain fail to resensitize after agonist treatment. Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors.

Navigating the future of roads – considering potential impacts of environmental and social trends on road infrastructure

Providing mobility corridors for communities, enabling freight networks to transport goods and services, and a pathway for emergency services and disaster relief operations, roads are a vital component of our societal system. In the coming decades, a number of modern issues will face road agencies as a result of climate change, resource scarcity and energy related challenges that will have implications for society. To date, these issues have been discussed on a case by case basis, leading to a fragmented approach by state and federal agencies in considering the future of roads – with potentially significant cost and risk implications. Within this context, this paper summarises part of a research project undertaken within the ‘Greening the Built Environment’ program of the Sustainable Built Environment National Research Centre (SBEnrc, Australia), which identified key factors or ‘trends’ affecting the future of roads and key strategies to ensure that road agencies can continue to deliver road infrastructure that meets societal needs in an environmentally appropriate manner. The research was conducted over two years, including a review of academic and state agency literature, four stakeholder workshops in Western Australia and Queensland, and industry consultation. The project was supported financially and through peer review and contribution, by Main Roads Western Australia, QLD Department of Transport and Main Roads, Parsons Brinckerhoff, John Holland Group, and the Australian Green Infrastructure Council (AGIC). The project highlighted several potential trends that are expected to affect road agencies in the future, including predicted resource and materials shortages, increases in energy and natural resources prices, increased costs related to greenhouse gas emissions, changing use and expectations of roads, and changes in the frequency and intensity of weather events. Exploring the implications of these potential futures, the study then developed a number of strategies in order to prepare transport agencies for the associated risks that such trends may present. An unintended outcome of the project was the development of a process for enquiring into future scenarios, which will be explored further in Stage 2 of the project (2013-2014). The study concluded that regardless of the type and scale of response by the agency, strategies must be holistic in approach, and remain dynamic and flexible.

Emerging issues for road construction and maintenance – A futuristic view

In the coming decades the design, construction and maintenance of roads will face a range of new issues and as such will require a number of new approaches. In particular, road authorities will be required to consider and respond to a range of issues related to climate change, and associated extreme weather events, such as the extensive flooding in January 2011 in Queensland, Australia Figure 1). Coupled with diminishing access to road construction supplies (such as aggregate), water scarcity, and the potential for increases in oil and electricity prices, this range of challenges bear little resemblance to those previously faced. In Australia, state and federal authorities face further pressures given the variety of needs resulting from the country's geographical and population diversity, expansive road networks, road freight requirements and relatively small population base.