Les diplômés – no 420, printemps 2011

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Avaliação da resistência à corrosão do aço AISI 420 depositado por processos variados de aspersão térmica

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Avaliação de biomarcadores de contaminação em tilápias do nilo (oreochromis niloticus) expostas aos herbicidas combine *500sc (tebutiurom) e velpar k® wg (diurom + hexazinona)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model

OBJECTIVES: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis and to determine its penetration into the CSF. METHODS: The experimental rabbit model was used in this study and EDP-420 was tested against a penicillin-resistant and a penicillin- and quinolone-resistant mutant. EDP-420 was also tested against both strains in time-killing assays over 8 h in vitro. RESULTS: In experimental meningitis, EDP-420 produced a bactericidal activity comparable to the standard regimen based on a combination of vancomycin with ceftriaxone against a penicillin-resistant Streptococcus pneumoniae and a penicillin- and quinolone-resistant S. pneumoniae isolate. The penetration of EDP-420 into inflamed meninges was 38% after an i.v. injection of 10 mg/kg. The bactericidal activity of EDP-420 was also confirmed in in vitro time-killing assays. CONCLUSIONS: EDP-420 is an efficacious alternative treatment in pneumococcal meningitis, especially when resistant strains are suspected.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 420 - Zitatensammlung aus Platon, Heredot, Aristoteles, Sophokles, Porphyrius, Plotinus

2 Seiten

Na 1 Nachlass Max Horkheimer, 593 - Korrespondenzen mit Friedrich (Frederick) Pollock (p. VI 39, 1-420)

1 Brief von Frederick Pollock an Albert Rosenberg, 28.12.1958; 1 Telegramm von Max Horkheimer an Albert Rosenberg, 05.01.1958; 2 Briefe zwischen Leo Löwenthal und Frederick Pollock, 1958; 1 Brief von Leo Löwenthal an Paul Lazarsfeld, 21.02.1958; 1 Brief von Paolo Bosia an Frederick Pollock, 03.05.1958; 1 Brief von der Deutschen Angestellten Gewerkschaft (Hamburg) an Max Horkheimer, 27.03.1958; 1 Brief von Max Horkheimer an E. Brüche, 11.04.1958; 1 Brief von Leo Löwenthal an Paul F. Lazarsfeld, 21.02.1958; 1 Brief von E. Heinicke an Emmy Henne, 10.03.1958; 1 Brief von Emmy Henne an das Hotel "Haus Westend" (Frankfurt/M.), 28.02.1958; 1 Brief von Frederick Pollock an Helene Weigel, 17.02.1958; 1 Brief von Frederick Pollock an Peter Alther (Rechtsanwalt), 09.11.1959; 1 Brief von Theodor W. Adorno an Frederick Pollock, 31.08.1959;